ID Q73WQ6_MYCPA Unreviewed; 763 AA.
AC Q73WQ6;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 111.
DE RecName: Full=Ketosynthase family 3 (KS3) domain-containing protein {ECO:0000259|PROSITE:PS52004};
GN OrderedLocusNames=MAP_2604c {ECO:0000313|EMBL:AAS04921.1};
OS Mycolicibacterium paratuberculosis (strain ATCC BAA-968 / K-10)
OS (Mycobacterium paratuberculosis).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium avium complex (MAC).
OX NCBI_TaxID=262316 {ECO:0000313|EMBL:AAS04921.1, ECO:0000313|Proteomes:UP000000580};
RN [1] {ECO:0000313|EMBL:AAS04921.1, ECO:0000313|Proteomes:UP000000580}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-968 / K-10 {ECO:0000313|Proteomes:UP000000580};
RX PubMed=16116077; DOI=10.1073/pnas.0505662102;
RA Li L., Bannantine J.P., Zhang Q., Amonsin A., May B.J., Alt D., Banerji N.,
RA Kanjilal S., Kapur V.;
RT "The complete genome sequence of Mycobacterium avium subspecies
RT paratuberculosis.";
RL Proc. Natl. Acad. Sci. U.S.A. 102:12344-12349(2005).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE016958; AAS04921.1; -; Genomic_DNA.
DR AlphaFoldDB; Q73WQ6; -.
DR STRING; 262316.MAP_2604c; -.
DR KEGG; mpa:MAP_2604c; -.
DR eggNOG; COG3321; Bacteria.
DR HOGENOM; CLU_000022_16_6_11; -.
DR Proteomes; UP000000580; Chromosome.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 3.30.70.250; Malonyl-CoA ACP transacylase, ACP-binding; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF37; FATTY ACID SYNTHASE; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000000580}.
FT DOMAIN 6..428
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
SQ SEQUENCE 763 AA; 79256 MW; BECF3532AD3D6E67 CRC64;
MPAATATPVA VIGMACRLPG GIDSPQRLWE ALLRGDDLVG EIPADRWDAD LYYDPEPGVP
GRSVTRWGAF LDDVGGFDCD FFGMTEREAT AVDPQHRLLL ETSWDAIEHA GLDPASLAGS
QTGVFVGLTH GDYELLSADC GAAEGPYGFT GTSNSFASGR VAYTLGLHGP AVTVDTACSS
GLMAVHQACG SLGGGESDLT LAGGVVVTLE PRKSVSGSLQ GMLSPTGRCH AFDVNADGFV
SGEGCVMLLL KRLDDARRDG DRILAVLRGT AANQDGRTVN IAAPSETAQV AVYRKALQAA
DIDATTVGLV EAHGTGTPVG DPIEYSSLAA VYGTDGPCVL GSVKTNFGHL QSASGPLGMM
KAILALQHGV VPRNLHFTRL PDEMARINTE LFVPQENTQW PSNGHHPRRA AVSSYGMSGT
NVHAILEEAP APEAAGSAAP EAVGPLLFPL SSTSAEQLRV TAARLAAWLD EQAGDALAGP
TGWGLRDLGY TLTRRRAHRP VRTVVSASGF AELRTELRAV ADGDIPYQPA VGQGDRGPVW
VFSGQGSQWS QMGAELLDKE PVFAATIAAV EPLIAAESGF SVTRALSAPP AVTGIDKVQP
TIFAMQVALA ETMKSYGVRP GAVIGHSLGE CAAAVVAGGL SLGDGVKVIC RRSRLMARIA
GRGAMASVEL PGQQVLSELS IRGISGVALS VVASPTSTVV GGGAEAIREL VAAWQQQDVM
AREVAVDVAS HSPQVESILD ELVEVLAELE PTAPEVPYYS ATL
//
