ID Q74HK0_LACJO Unreviewed; 443 AA.
AC Q74HK0;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 24-JAN-2024, entry version 117.
DE RecName: Full=Permease IIC component {ECO:0000256|PIRNR:PIRNR006351};
GN OrderedLocusNames=LJ_0531 {ECO:0000313|EMBL:AAS09690.1};
OS Lactobacillus johnsonii (strain CNCM I-12250 / La1 / NCC 533).
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Lactobacillus.
OX NCBI_TaxID=257314 {ECO:0000313|EMBL:AAS09690.1, ECO:0000313|Proteomes:UP000000581};
RN [1] {ECO:0000313|EMBL:AAS09690.1, ECO:0000313|Proteomes:UP000000581}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CNCM I-1225 / La1 / NCC 533
RC {ECO:0000313|Proteomes:UP000000581};
RX PubMed=14983040; DOI=10.1073/pnas.0307327101;
RA Pridmore R.D., Berger B., Desiere F., Vilanova D., Barretto C.,
RA Pittet A.-C., Zwahlen M.-C., Rouvet M., Altermann E., Barrangou R.,
RA Mollet B., Mercenier A., Klaenhammer T., Arigoni F., Schell M.A.;
RT "The genome sequence of the probiotic intestinal bacterium Lactobacillus
RT johnsonii NCC 533.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2512-2517(2004).
CC -!- FUNCTION: The phosphoenolpyruvate-dependent sugar phosphotransferase
CC system (PTS), a major carbohydrate active -transport system, catalyzes
CC the phosphorylation of incoming sugar substrates concomitant with their
CC translocation across the cell membrane.
CC {ECO:0000256|PIRNR:PIRNR006351}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AE017198; AAS09690.1; -; Genomic_DNA.
DR RefSeq; WP_004898057.1; NC_005362.1.
DR AlphaFoldDB; Q74HK0; -.
DR GeneID; 83571156; -.
DR KEGG; ljo:LJ_0531; -.
DR eggNOG; COG1455; Bacteria.
DR HOGENOM; CLU_029688_1_0_9; -.
DR Proteomes; UP000000581; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0008982; F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0009401; P:phosphoenolpyruvate-dependent sugar phosphotransferase system; IEA:InterPro.
DR InterPro; IPR003352; PTS_EIIC.
DR InterPro; IPR004501; PTS_EIIC_3.
DR InterPro; IPR004796; PTS_IIC_cello.
DR NCBIfam; TIGR00410; lacE; 1.
DR PANTHER; PTHR33989; -; 1.
DR PANTHER; PTHR33989:SF4; PTS SYSTEM N,N'-DIACETYLCHITOBIOSE-SPECIFIC EIIC COMPONENT; 1.
DR Pfam; PF02378; PTS_EIIC; 1.
DR PIRSF; PIRSF006351; PTS_EIIC-Cellobiose; 1.
DR PROSITE; PS51105; PTS_EIIC_TYPE_3; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|PIRNR:PIRNR006351};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR006351};
KW Sugar transport {ECO:0000256|ARBA:ARBA00022597,
KW ECO:0000256|PIRNR:PIRNR006351};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR006351}.
FT TRANSMEM 36..56
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 77..98
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 110..128
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 140..166
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 186..206
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 226..249
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 298..319
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 352..377
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 397..425
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 12..427
FT /note="PTS EIIC type-3"
FT /evidence="ECO:0000259|PROSITE:PS51105"
SQ SEQUENCE 443 AA; 47867 MW; 1738D107C7BBF8F4 CRC64;
MSDRSNAVNA WVNKNIMPIA AKIGAFKPLI AIRDGIAMAM PLIIVGSLFM VINGFPITAW
TNFLTKTAVH GVSLSQILVK VSNGSFGIMG LIAAFGIAWS YANQYKTDGV SAGIISASVF
FIVTPSIMSG GKTPAEGFPY VYLGSRGLFV AIFLGLLSAW IFQWFINHNI QIKMPDTVPP
AVAKSFSALI PGTVCIFLAG CIYWLFSWAH WGNLHDVIMN ILAKPLGLLG NTLLGTLASI
ILVSLFWFVG IHGGNVVNTA MSPIWLMQTD ANRVLNQSGK LDLAHGGNII TQPFIDNFVY
MGGAGATLGL VLCVGYLVWK KRASKQNEIL APLTIVPGIF NINEPTMFGL PVVLNLSLII
PFIIAPMFNA ITTYTAMKLG WVPLCNGTVI PWTMPPLISG FLATNSIAGS ILQLFNIIVD
ILIYLPFMSA LNKRQIVEES RKG
//
