ID Q74NB0_NANEQ Unreviewed; 444 AA.
AC Q74NB0;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 91.
DE SubName: Full=NEQ148 {ECO:0000313|EMBL:AAR39003.1};
GN OrderedLocusNames=NEQ148 {ECO:0000313|EMBL:AAR39003.1};
OS Nanoarchaeum equitans (strain Kin4-M).
OC Archaea; Nanoarchaeota; Candidatus Nanoarchaeia; Nanoarchaeales;
OC Nanoarchaeaceae; Nanoarchaeum.
OX NCBI_TaxID=228908 {ECO:0000313|EMBL:AAR39003.1, ECO:0000313|Proteomes:UP000000578};
RN [1] {ECO:0000313|EMBL:AAR39003.1, ECO:0000313|Proteomes:UP000000578}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Kin4-M {ECO:0000313|EMBL:AAR39003.1,
RC ECO:0000313|Proteomes:UP000000578};
RX PubMed=14566062; DOI=10.1073/pnas.1735403100;
RA Waters E., Hohn M.J., Ahel I., Graham D.E., Adams M.D., Barnstead M.,
RA Beeson K.Y., Bibbs L., Bolanos R., Keller M., Kretz K., Lin X., Mathur E.,
RA Ni J., Podar M., Richardson T., Sutton G.G., Simon M., Soll D.,
RA Stetter K.O., Short J.M., Noordewier M.;
RT "The genome of Nanoarchaeum equitans: insights into early archaeal
RT evolution and derived parasitism.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:12984-12988(2003).
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
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DR EMBL; AE017199; AAR39003.1; -; Genomic_DNA.
DR AlphaFoldDB; Q74NB0; -.
DR STRING; 228908.NEQ148; -.
DR EnsemblBacteria; AAR39003; AAR39003; NEQ148.
DR KEGG; neq:NEQ148; -.
DR PATRIC; fig|228908.8.peg.151; -.
DR HOGENOM; CLU_042889_0_0_2; -.
DR BioCyc; NEQU228908:GJB6-159-MONOMER; -.
DR Proteomes; UP000000578; Chromosome.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031419; F:cobalamin binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR CDD; cd01335; Radical_SAM; 1.
DR CDD; cd02068; radical_SAM_B12_BD; 1.
DR Gene3D; 3.40.50.280; Cobalamin-binding domain; 1.
DR Gene3D; 3.80.30.20; tm_1862 like domain; 1.
DR InterPro; IPR023980; CHP04013_B12-bd/rSAM.
DR InterPro; IPR006158; Cobalamin-bd.
DR InterPro; IPR006638; Elp3/MiaA/NifB-like_rSAM.
DR InterPro; IPR020612; Methylthiotransferase_CS.
DR InterPro; IPR007197; rSAM.
DR InterPro; IPR023404; rSAM_horseshoe.
DR NCBIfam; TIGR04013; B12_SAM_MJ_1487; 1.
DR PANTHER; PTHR43409:SF7; ANAEROBIC MAGNESIUM-PROTOPORPHYRIN IX MONOMETHYL ESTER CYCLASE; 1.
DR PANTHER; PTHR43409; ANAEROBIC MAGNESIUM-PROTOPORPHYRIN IX MONOMETHYL ESTER CYCLASE-RELATED; 1.
DR Pfam; PF02310; B12-binding; 1.
DR Pfam; PF04055; Radical_SAM; 1.
DR SFLD; SFLDG01082; B12-binding_domain_containing; 1.
DR SFLD; SFLDS00029; Radical_SAM; 1.
DR SMART; SM00729; Elp3; 1.
DR SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR PROSITE; PS51332; B12_BINDING; 1.
DR PROSITE; PS01278; MTTASE_RADICAL; 1.
DR PROSITE; PS51918; RADICAL_SAM; 1.
PE 4: Predicted;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW Iron {ECO:0000256|ARBA:ARBA00022485};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00022485};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022485};
KW Reference proteome {ECO:0000313|Proteomes:UP000000578}.
FT DOMAIN 1..123
FT /note="B12-binding"
FT /evidence="ECO:0000259|PROSITE:PS51332"
FT DOMAIN 158..389
FT /note="Radical SAM core"
FT /evidence="ECO:0000259|PROSITE:PS51918"
FT REGION 420..444
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 444 AA; 51170 MW; AFC7D14D15D4CD0B CRC64;
MHTVIAIRLT KNNRNAFSYL LGALEKQGFD INEIAIARSF EDLIKTKPKI VLYSFYSTEV
WEVKKEIQML KSKINAIAIA GGYHASAMPR HTLKMGFDIA VVGEGEETLY YLLENLKKNK
AINKDLLTIR GLAFNLNGYK FTGFAKVEDF YKYPPFAESI RMVGPIEISR GCPFGCNYCQ
TPFFKGFRMR HRPIDQIVKH SRYLRDMRYI SPNAFAYGSP GAILVLEKLE ALLRALQPLR
KEGRRLFFGT FPSEVRPEFV IPETLELLLK YADNRKIIIG AQSGDNRILK LMHRLHDVET
IKRAVEYSIE YGFTPIVDFI VGTPYEDEES DRNTIELMKW IISKGGKVRA HYFMPLPGTP
WALCKPKPLS KEMVRFLGTM ARQSKLEGEW VKQIELSNKL HSLIKENYEE ATGYYGPIPN
RCINDEQTNK NDNQNKNPQK ERNN
//
