ID   Q75XX1_9PLEU            Unreviewed;       530 AA.
AC   Q75XX1;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   27-MAR-2024, entry version 61.
DE   RecName: Full=UDP-glucuronosyltransferase {ECO:0000256|RuleBase:RU362059};
DE            EC=2.4.1.17 {ECO:0000256|RuleBase:RU362059};
GN   Name=UGT1B2 {ECO:0000313|EMBL:BAC87829.1};
OS   Pseudopleuronectes yokohamae (marbled flounder).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Carangaria; Pleuronectiformes; Pleuronectoidei; Pleuronectidae;
OC   Pseudopleuronectes.
OX   NCBI_TaxID=245875 {ECO:0000313|EMBL:BAC87829.1};
RN   [1] {ECO:0000313|EMBL:BAC87829.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Liver {ECO:0000313|EMBL:BAC87829.1};
RA   Miyasho T., Yokota H.;
RT   "cDNA cloning of UDP-glucuronosyltransferase from Marbled sole
RT   (Pleuronectes yokohamae) liver.";
RL   Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor
CC         beta-D-glucuronoside + H(+) + UDP; Xref=Rhea:RHEA:21032,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223,
CC         ChEBI:CHEBI:132367, ChEBI:CHEBI:132368; EC=2.4.1.17;
CC         Evidence={ECO:0000256|RuleBase:RU362059};
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000256|ARBA:ARBA00004389}; Single-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004389}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004167, ECO:0000256|RuleBase:RU362059}; Single-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004167,
CC       ECO:0000256|RuleBase:RU362059}.
CC   -!- SIMILARITY: Belongs to the UDP-glycosyltransferase family.
CC       {ECO:0000256|ARBA:ARBA00009995, ECO:0000256|RuleBase:RU003718}.
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DR   EMBL; AB120133; BAC87829.1; -; mRNA.
DR   AlphaFoldDB; Q75XX1; -.
DR   CAZy; GT1; Glycosyltransferase Family 1.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015020; F:glucuronosyltransferase activity; IEA:UniProtKB-EC.
DR   CDD; cd03784; GT1_Gtf-like; 1.
DR   Gene3D; 3.40.50.2000; Glycogen Phosphorylase B; 2.
DR   InterPro; IPR002213; UDP_glucos_trans.
DR   InterPro; IPR035595; UDP_glycos_trans_CS.
DR   PANTHER; PTHR48043; EG:EG0003.4 PROTEIN-RELATED; 1.
DR   PANTHER; PTHR48043:SF157; UDP GLUCURONOSYLTRANSFERASE 1 FAMILY POLYPEPTIDE A3 PRECURSOR-RELATED; 1.
DR   Pfam; PF00201; UDPGT; 1.
DR   SUPFAM; SSF53756; UDP-Glycosyltransferase/glycogen phosphorylase; 1.
DR   PROSITE; PS00375; UDPGT; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW   Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676,
KW   ECO:0000256|RuleBase:RU003718}; Membrane {ECO:0000256|RuleBase:RU362059};
KW   Signal {ECO:0000256|RuleBase:RU362059};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003718};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU362059};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU362059}.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000256|RuleBase:RU362059"
FT   CHAIN           27..530
FT                   /note="UDP-glucuronosyltransferase"
FT                   /evidence="ECO:0000256|RuleBase:RU362059"
FT                   /id="PRO_5005144202"
FT   TRANSMEM        493..513
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362059"
SQ   SEQUENCE   530 AA;  59901 MW;  76BB6495E8591E98 CRC64;
     MSGRVWFPSL GLVAWLCLLS LGPVQGGKVL VMPADGSHWL SLKILVKGLV HRGHDVVVLV
     PESSLFMHQS EDYKTEVYPV SFTMEEMDAV HKQLKDGLFL KQPDWTEYYV NIMRFVNFTS
     IHLRGCENLL QNQPLMSRLK GMGFDIVLTD PFFPCGALVG HIFSIPVVNF LRGLPCGLDM
     KVNKCPSPPS YIPVPYSGHT DIMTFQQRVI NMAMTVVESF QCSLLYSHYD EMVSKHLGNN
     MDYRTLLSNG ALWLIRNEFS LDWPRPLLPN MVLIGGINCA EKKTKASLPA DLEEFVQGSG
     DHGFIIFTLG SMLPDMPQEM AQHFLDAFRQ IPQRVVWRYA GEPPKGLPKN VKLMKWLPQK
     DLLAHPKAKL FLTHGGSHSV FEGICNAVPM LMFPLFAEQG DNGLRMVTRG VAETLFIYDV
     TSDTLLATLN KILKNKSYKE KMTELSQIHH DRPVGPLDLA IFWTEFVIRH KGAAHLRVSA
     HDLNWIQYHS LDVFGFLLLI LLTVLLVTLK CCLSCTRRCC RRGTAKTKSE
//