ID Q76N38_HHV2 Unreviewed; 375 AA.
AC Q76N38;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=Thymidine kinase {ECO:0000313|EMBL:BAA23731.1};
GN Name=UL23 {ECO:0000313|EMBL:BAA23731.1};
OS Human herpesvirus 2 (HHV-2) (Human herpes simplex virus 2).
OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC Herpesvirales; Orthoherpesviridae; Alphaherpesvirinae; Simplexvirus;
OC Simplexvirus humanalpha2.
OX NCBI_TaxID=10310 {ECO:0000313|EMBL:BAA23731.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:BAA23731.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=UW268 {ECO:0000313|EMBL:BAA23731.1};
RX PubMed=8577269;
RA Suzutani T., Koyano S., Takada M., Yoshida I., Azuma M.;
RT "Analysis of the relationship between cellular thymidine kinase activity
RT and virulence of thymidine kinase-negative herpes simplex virus types 1 and
RT 2.";
RL Microbiol. Immunol. 39:787-794(1995).
RN [2] {ECO:0000313|EMBL:BAA23731.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=UW268 {ECO:0000313|EMBL:BAA23731.1};
RA Suzutani T.;
RL Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; AB009256; BAA23731.1; -; Genomic_DNA.
DR SMR; Q76N38; -.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004797; F:thymidine kinase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0071897; P:DNA biosynthetic process; IEA:UniProtKB-UniRule.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0006230; P:TMP biosynthetic process; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_04029; HSV_KITH; 1.
DR InterPro; IPR001889; Herpes_TK.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00693; Herpes_TK; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:BAA23731.1};
KW Transferase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:BAA23731.1}.
FT REGION 1..47
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 375 AA; 40370 MW; E9CFEF87CBD25A94 CRC64;
MASHAGQQHA PAFGQAARAS GPTDGRAASR PSHRQGASEA RGDPELPTLL RVYIDGPHGV
GKTTTSAQLM EALGPRDNIV YVPEPMTYWQ VLGASETLTN IYNTQHRLDR GEISAGEAAV
VMTSAQITMS TPYAATDAVL APHIGGEAVG PQAPPPALTL VFDRHPIASL LCYPAARYLM
GSMTPQAVLA FVALMPPTAP GTNLVLGVLP EAEHADRLAR RQRPGERLDL AMLSAIRRVY
DLLANTVRYL QRGGRWREDW GRLTGVAAAT RPDPEDGAGS LPRIEDTLFA LFRVPELLAP
NGDLYHIFAW VLDVLADRLL PMHLFVLDYD QSPVGCRDAL LRLTAGMIPT RVTTAGSIAE
IRDLARTFAR EVGGV
//
