ID Q79Z56_STRAW Unreviewed; 428 AA.
AC Q79Z56;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=3-oxoacyl-ACP synthase I {ECO:0000313|EMBL:BAC71377.1};
GN Name=pks8-8 {ECO:0000313|EMBL:BAC71377.1};
GN ORFNames=SAVERM_3665 {ECO:0000313|EMBL:BAC71377.1};
OS Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC
OS 14893 / NCIMB 12804 / NRRL 8165 / MA-4680).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=227882 {ECO:0000313|EMBL:BAC71377.1, ECO:0000313|Proteomes:UP000000428};
RN [1] {ECO:0000313|EMBL:BAC71377.1, ECO:0000313|Proteomes:UP000000428}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 /
RC NRRL 8165 / MA-4680 {ECO:0000313|Proteomes:UP000000428};
RX PubMed=11572948; DOI=10.1073/pnas.211433198;
RA Omura S., Ikeda H., Ishikawa J., Hanamoto A., Takahashi C., Shinose M.,
RA Takahashi Y., Horikawa H., Nakazawa H., Osonoe T., Kikuchi H., Shiba T.,
RA Sakaki Y., Hattori M.;
RT "Genome sequence of an industrial microorganism Streptomyces avermitilis:
RT deducing the ability of producing secondary metabolites.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:12215-12220(2001).
RN [2] {ECO:0000313|EMBL:BAC71377.1, ECO:0000313|Proteomes:UP000000428}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 /
RC NRRL 8165 / MA-4680 {ECO:0000313|Proteomes:UP000000428};
RX PubMed=12692562; DOI=10.1038/nbt820;
RA Ikeda H., Ishikawa J., Hanamoto A., Shinose M., Kikuchi H., Shiba T.,
RA Sakaki Y., Hattori M., Omura S.;
RT "Complete genome sequence and comparative analysis of the industrial
RT microorganism Streptomyces avermitilis.";
RL Nat. Biotechnol. 21:526-531(2003).
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP
CC synthases family. {ECO:0000256|ARBA:ARBA00008467,
CC ECO:0000256|RuleBase:RU003694}.
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DR EMBL; BA000030; BAC71377.1; -; Genomic_DNA.
DR RefSeq; WP_010985096.1; NZ_JZJK01000090.1.
DR AlphaFoldDB; Q79Z56; -.
DR KEGG; sma:SAVERM_3665; -.
DR eggNOG; COG0304; Bacteria.
DR HOGENOM; CLU_000022_69_0_11; -.
DR OrthoDB; 9808669at2; -.
DR Proteomes; UP000000428; Chromosome.
DR GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:UniProt.
DR CDD; cd00834; KAS_I_II; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR000794; Beta-ketoacyl_synthase.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR11712:SF336; 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11712; POLYKETIDE SYNTHASE-RELATED; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS52004; KS3_2; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000000428};
KW Transferase {ECO:0000256|RuleBase:RU003694}.
FT DOMAIN 24..423
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 428 AA; 44579 MW; 2E47686B143FD462 CRC64;
MNASINTDAR GHGGPEDPRP EAAGRRVVIT GLGVVTSIGI GVEAFTAGLR AGRSGVKPIT
AFDTTGFAHA NGCEVTDFEP ERWLDRQHPE ELGRASQFAV AAARMAVADA GLHEEDVRAR
RSLVSVGTTD GESRDLDQLV AAGLENGPEE YEPAVARRIP AGRLSAGIVR ELELEDVEAV
TIPTACAAGN YAVGYGYDAL RSGDVDIALC GGADAACRKT FTGFYRLGTI APEVCRPFDK
DREGILTGEG AGILLMESLD SALARGARIY AEVLGYGLAC DALHPVAPDR DSIARTIRIA
HRNAGITPDQ VDFVSAHGTG TKANDITEAG AIRQVFGEDA MPRTVSIKSM IGHSMGAASA
VSAAACALAI TEGFIPPTVN HRETDPECGV DCVPNQAVET ELSVVQNNAL AFGGNNAVLI
LGAYRSAA
//
