ID Q7BL43_SALTM Unreviewed; 263 AA.
AC Q7BL43; A1YJL2;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 24-JAN-2024, entry version 84.
DE RecName: Full=Aminoglycoside (3'') (9) adenylyltransferase {ECO:0000256|ARBA:ARBA00035252, ECO:0000256|PIRNR:PIRNR000819};
DE EC=2.7.7.47 {ECO:0000256|ARBA:ARBA00035126, ECO:0000256|PIRNR:PIRNR000819};
GN Name=aadA2 {ECO:0000313|EMBL:AAK02046.1};
GN Synonyms=aadA {ECO:0000313|EMBL:MLP86625.1};
GN ORFNames=AVC05_05990 {ECO:0000313|EMBL:ECY5340796.1}, AVC05_24840
GN {ECO:0000313|EMBL:ECY5344416.1}, DRM14_15060
GN {ECO:0000313|EMBL:MLP86625.1}, DRM14_25780
GN {ECO:0000313|EMBL:MLP88649.1}, E0935_26490
GN {ECO:0000313|EMBL:ECF1546735.1}, E0935_26515
GN {ECO:0000313|EMBL:ECF1546740.1}, GB466_21895
GN {ECO:0000313|EMBL:HAB0973182.1};
OS Salmonella typhimurium.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=90371 {ECO:0000313|EMBL:AAK02046.1};
RN [1] {ECO:0000313|EMBL:AAK02046.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=96-5227 {ECO:0000313|EMBL:AAK02046.1};
RX PubMed=11544236; DOI=10.1128/JB.183.19.5725-5732.2001;
RA Boyd D., Peters G.A., Cloeckaert A., Boumedine K.S., Chaslus-Dancla E.,
RA Imberechts H., Mulvey M.R.;
RT "Complete nucleotide sequence of a 43-kilobase genomic island associated
RT with the multidrug resistance region of Salmonella enterica serovar
RT Typhimurium DT104 and its identification in phage type DT120 and serovar
RT Agona.";
RL J. Bacteriol. 183:5725-5732(2001).
RN [2] {ECO:0000313|EMBL:ABL95948.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=BF272 {ECO:0000313|EMBL:ABL95948.1};
RX PubMed=17283193; DOI=10.1128/AAC.01275-06;
RA Antunes P., Machado J., Peixe L.;
RT "Dissemination of sul3-containing elements linked to class 1 integrons with
RT an unusual 3' conserved sequence region among Salmonella isolates.";
RL Antimicrob. Agents Chemother. 51:1545-1548(2007).
RN [3] {ECO:0000313|EMBL:ACS54272.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Sopus02-4 {ECO:0000313|EMBL:ACS54272.1};
RX PubMed=19573249; DOI=10.1186/1471-2180-9-131;
RA Wiesner M., Zaidi M.B., Calva E., Fernandez-Mora M., Calva J.J., Silva C.;
RT "Association of virulence plasmid and antibiotic resistance determinants
RT with chromosomal multilocus genotypes in Mexican Salmonella enterica
RT serovar Typhimurium strains.";
RL BMC Microbiol. 9:131-131(2009).
RN [4] {ECO:0000313|EMBL:HAB0973182.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Salmonella enterica {ECO:0000313|EMBL:HAB0973182.1};
RX PubMed=30286803;
RA Souvorov A., Agarwala R., Lipman D.J.;
RT "SKESA: strategic k-mer extension for scrupulous assemblies.";
RL Genome Biol. 19:153-153(2018).
RN [5] {ECO:0000313|EMBL:ECY5340796.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=265852 {ECO:0000313|EMBL:ECF1546735.1}, 425567
RC {ECO:0000313|EMBL:MLP86625.1}, and 43916
RC {ECO:0000313|EMBL:ECY5340796.1};
RA Ashton P.M., Dallman T., Nair S., De Pinna E., Peters T., Grant K.;
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
RN [6] {ECO:0000313|EMBL:HAB0973182.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Salmonella enterica {ECO:0000313|EMBL:HAB0973182.1};
RG NCBI Pathogen Detection Project;
RL Submitted (OCT-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + spectinomycin = 9-O-adenylylspectinomycin + diphosphate;
CC Xref=Rhea:RHEA:63228, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019,
CC ChEBI:CHEBI:146260, ChEBI:CHEBI:146261;
CC Evidence={ECO:0000256|ARBA:ARBA00001672,
CC ECO:0000256|PIRNR:PIRNR000819};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + streptomycin = 3''-O-adenylylstreptomycin + diphosphate;
CC Xref=Rhea:RHEA:20245, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019,
CC ChEBI:CHEBI:58007, ChEBI:CHEBI:58605; EC=2.7.7.47;
CC Evidence={ECO:0000256|ARBA:ARBA00035070,
CC ECO:0000256|PIRNR:PIRNR000819};
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DR EMBL; AF261825; AAK02046.1; -; Genomic_DNA.
DR EMBL; EF051039; ABL95948.1; -; Genomic_DNA.
DR EMBL; FJ460233; ACS54272.1; -; Genomic_DNA.
DR EMBL; AAIKGB010000111; ECF1546735.1; -; Genomic_DNA.
DR EMBL; AAIKGB010000112; ECF1546740.1; -; Genomic_DNA.
DR EMBL; AALDNI010000009; ECY5340796.1; -; Genomic_DNA.
DR EMBL; AALDNI010000145; ECY5344416.1; -; Genomic_DNA.
DR EMBL; DAAFPQ010000024; HAB0973182.1; -; Genomic_DNA.
DR EMBL; RVDJ01000014; MLP86625.1; -; Genomic_DNA.
DR EMBL; RVDJ01000080; MLP88649.1; -; Genomic_DNA.
DR KEGG; seni:CY43_20060; -.
DR PATRIC; fig|90371.686.peg.4248; -.
DR Proteomes; UP000839595; Unassembled WGS sequence.
DR Proteomes; UP000839617; Unassembled WGS sequence.
DR Proteomes; UP000885385; Unassembled WGS sequence.
DR GO; GO:0070566; F:adenylyltransferase activity; IEA:InterPro.
DR GO; GO:0009012; F:aminoglycoside 3''-adenylyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR CDD; cd05403; NT_KNTase_like; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR InterPro; IPR024172; AadA/Aad9.
DR InterPro; IPR025184; AadA_C.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR002934; Polymerase_NTP_transf_dom.
DR Pfam; PF13427; AadA_C; 1.
DR Pfam; PF01909; NTP_transf_2; 1.
DR PIRSF; PIRSF000819; Streptomycin_3-adenylyltransf; 1.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
PE 4: Predicted;
KW Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251,
KW ECO:0000256|PIRNR:PIRNR000819};
KW ATP-binding {ECO:0000256|PIRNR:PIRNR000819};
KW Nucleotide-binding {ECO:0000256|PIRNR:PIRNR000819};
KW Nucleotidyltransferase {ECO:0000256|PIRNR:PIRNR000819};
KW Transferase {ECO:0000256|PIRNR:PIRNR000819, ECO:0000313|EMBL:ABL95948.1}.
FT DOMAIN 28..97
FT /note="Polymerase nucleotidyl transferase"
FT /evidence="ECO:0000259|Pfam:PF01909"
FT DOMAIN 153..254
FT /note="Adenylyltransferase AadA C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13427"
SQ SEQUENCE 263 AA; 29549 MW; D7FB27184F7D6B26 CRC64;
MRVAVTIEIS NQLSEVLSVI ERHLESTLLA VHLYGSAVDG GLKPYSDIDL LVTVAVKLDE
TTRRALLNDL MEASAFPGES ETLRAIEVTL VVHDDIIPWR YPAKRELQFG EWQRNDILAG
IFEPAMIDID LAILLTKARE HSVALVGPAA EEFFDPVPEQ DLFEALRETL KLWNSQPDWA
GDERNVVLTL SRIWYSAITG KIAPKDVAAD WAIKRLPAQY QPVLLEAKQA YLGQKEDHLA
SRADHLEEFI RFVKGEIIKS VGK
//
