ID Q7MDR8_VIBVY Unreviewed; 461 AA.
AC Q7MDR8;
DT 15-DEC-2003, integrated into UniProtKB/TrEMBL.
DT 15-DEC-2003, sequence version 1.
DT 27-MAR-2024, entry version 94.
DE SubName: Full=Predicted Zn-dependent protease {ECO:0000313|EMBL:BAC96994.1};
GN OrderedLocusNames=VVA0968 {ECO:0000313|EMBL:BAC96994.1};
OS Vibrio vulnificus (strain YJ016).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Vibrio.
OX NCBI_TaxID=196600 {ECO:0000313|EMBL:BAC96994.1, ECO:0000313|Proteomes:UP000002675};
RN [1] {ECO:0000313|EMBL:BAC96994.1, ECO:0000313|Proteomes:UP000002675}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YJ016 {ECO:0000313|EMBL:BAC96994.1,
RC ECO:0000313|Proteomes:UP000002675};
RX PubMed=14656965; DOI=10.1101/gr.1295503;
RA Chen C.Y., Wu K.M., Chang Y.C., Chang C.H., Tsai H.C., Liao T.L., Liu Y.M.,
RA Chen H.J., Shen A.B., Li J.C., Su T.L., Shao C.P., Lee C.T., Hor L.I.,
RA Tsai S.F.;
RT "Comparative genome analysis of Vibrio vulnificus, a marine pathogen.";
RL Genome Res. 13:2577-2587(2003).
CC -!- SIMILARITY: Belongs to the peptidase U62 family.
CC {ECO:0000256|ARBA:ARBA00005836}.
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DR EMBL; BA000038; BAC96994.1; -; Genomic_DNA.
DR RefSeq; WP_011152265.1; NC_005140.1.
DR AlphaFoldDB; Q7MDR8; -.
DR STRING; 672.VV93_v1c39050; -.
DR KEGG; vvy:VVA0968; -.
DR PATRIC; fig|196600.6.peg.4139; -.
DR eggNOG; COG0312; Bacteria.
DR HOGENOM; CLU_026425_1_0_6; -.
DR Proteomes; UP000002675; Chromosome II.
DR GO; GO:0008237; F:metallopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.30.2290.10; PmbA/TldD superfamily; 1.
DR InterPro; IPR045569; Metalloprtase-TldD/E_C.
DR InterPro; IPR045570; Metalloprtase-TldD/E_cen_dom.
DR InterPro; IPR002510; Metalloprtase-TldD/E_N.
DR InterPro; IPR025502; TldD.
DR InterPro; IPR035068; TldD/PmbA_N.
DR InterPro; IPR036059; TldD/PmbA_sf.
DR PANTHER; PTHR30624:SF4; METALLOPROTEASE TLDD; 1.
DR PANTHER; PTHR30624; UNCHARACTERIZED PROTEIN TLDD AND PMBA; 1.
DR Pfam; PF01523; PmbA_TldD_1st; 1.
DR Pfam; PF19290; PmbA_TldD_2nd; 1.
DR Pfam; PF19289; PmbA_TldD_3rd; 1.
DR PIRSF; PIRSF004919; TldD; 1.
DR SUPFAM; SSF111283; Putative modulator of DNA gyrase, PmbA/TldD; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000313|EMBL:BAC96994.1}.
FT DOMAIN 22..78
FT /note="Metalloprotease TldD/E N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01523"
FT DOMAIN 114..220
FT /note="Metalloprotease TldD/E central"
FT /evidence="ECO:0000259|Pfam:PF19290"
FT DOMAIN 227..459
FT /note="Metalloprotease TldD/E C-terminal"
FT /evidence="ECO:0000259|Pfam:PF19289"
SQ SEQUENCE 461 AA; 49736 MW; 4EC36ED7F9082482 CRC64;
MLNPVTAKAV IDHALFLGAD FAELFVEHHQ TNSIQFNSQE VDKINSGIDF GIGIRLFFGH
KVLYGFTNST EESELKRVTS LLAAKDKRDQ IVQAGSLNLI RYPVQHVSHQ PLSKDPYLDS
KIAFLHQADL AARAQSDKIT QFMGSVLQRE QQIEIFNSEG LNIGDTRHYT RVATNAVAQD
GSEQSVGMEG PGALMGWEFS QQLDAKALGQ EVAEQALVKL NADVCPSGEM PVVIGNGFGG
VIFHEACGHL LETTSVAKKA SVFHDKMGEM IAHSAVSAVD DGTMTNEWGS IHIDDEGMET
QRTQLIKDGK LTSFMVDKMG GLKTGYAPTG SGRRQNYKFA PTSRMRNTFI EEGDSTFDEM
ISSIEKGIYA KKLGGGSVQP GTGEFNFAVR EAYLIENGKI TKPLKTATLI STGPKVLKEI
SMVGKDMALA PGMCGSVSGS VPTTVGQPSL KVDKILVGGG N
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