ID Q7P1B7_CHRVO Unreviewed; 241 AA.
AC Q7P1B7;
DT 15-DEC-2003, integrated into UniProtKB/TrEMBL.
DT 15-DEC-2003, sequence version 1.
DT 27-MAR-2024, entry version 102.
DE RecName: Full=Guanine nucleotide exchange factor {ECO:0000256|PIRNR:PIRNR034781};
GN OrderedLocusNames=CV_0296 {ECO:0000313|EMBL:AAQ57975.1};
OS Chromobacterium violaceum (strain ATCC 12472 / DSM 30191 / JCM 1249 / NBRC
OS 12614 / NCIMB 9131 / NCTC 9757).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Neisseriales;
OC Chromobacteriaceae; Chromobacterium.
OX NCBI_TaxID=243365 {ECO:0000313|EMBL:AAQ57975.1, ECO:0000313|Proteomes:UP000001424};
RN [1] {ECO:0000313|EMBL:AAQ57975.1, ECO:0000313|Proteomes:UP000001424}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 12472 / DSM 30191 / JCM 1249 / NBRC 12614 / NCIMB 9131 /
RC NCTC 9757 {ECO:0000313|Proteomes:UP000001424};
RX PubMed=14500782; DOI=10.1073/pnas.1832124100;
RA Vasconcelos A.T.R., de Almeida D.F., Almeida F.C., de Almeida L.G.P.,
RA de Almeida R., Goncalves J.A.A., Andrade E.M., Antonio R.V., Araripe J.,
RA de Araujo M.F.F., Filho S.A., Azevedo V., Batista A.J., Bataus L.A.M.,
RA Batista J.S., Belo A., vander Berg C., Blamey J., Bogo M., Bonato S.,
RA Bordignon J., Brito C.A., Brocchi M., Burity H.A., Camargo A.A.,
RA Cardoso D.D.P., Carneiro N.P., Carraro D.M., Carvalho C.M.B.,
RA Cascardo J.C.M., Cavada B.S., Chueire L.M.O., Pasa T.B.C., Duran N.,
RA Fagundes N., Falcao C.L., Fantinatti F., Farias I.P., Felipe M.S.S.,
RA Ferrari L.P., Ferro J.A., Ferro M.I.T., Franco G.R., Freitas N.S.A.,
RA Furlan L.R., Gazzinelli R.T., Gomes E.A., Goncalves P.R., Grangeiro T.B.,
RA Grattapaglia D., Grisard E.C., Guimaraes C.T., Hanna E.S., Hungria M.,
RA Jardim S.N., Laurino J., Leoi L.C.T., Fassarella L., Lima A.,
RA Loureiro M.F., Lyra M.C.P., Macedo M., Madeira H.M.F., Manfio G.P.,
RA Maranhao A.Q., Martins W.S., di Mauro S.M.Z., de Medeiros S.R.B.,
RA Meissner R.D.V., Menck C.F.M., Moreira M.A.M., Nascimento F.F.,
RA Nicolas M.F., Oliveira J.G., Oliveira S.C., Paixao R.F.C., Parente J.A.,
RA Pedrosa F.O., Pena S.J.D., Perreira J.O., Perreira M., Pinto L.S.R.C.,
RA Pinto L.S., Porto J.I.R., Potrich D.P., Neto C.E.R., Reis A.M.M.,
RA Rigo L.U., Rondinelli E., dos Santos E.B.P., Santos F.R., Schneider M.P.C.,
RA Seuanez H.N., Silva A.M.R., da Silva A.L.C., Silva D.W., Silva R.,
RA Simoes I.C., Simon D., Soares C.M.A., Soares R.B.A., Souza E.M.,
RA Souza K.R.L., Souza R.C., Steffens M.B.R., Steindel M., Teixeira S.R.,
RA Urmenyi T., Vettore A., Wassem R., Zaha A., Simpson A.J.G.;
RT "The complete genome sequence of Chromobacterium violaceum reveals
RT remarkable and exploitable bacterial adaptability.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:11660-11665(2003).
CC -!- FUNCTION: Activator for both CDC42 and RAC1 by directly interacting
CC with these Rho GTPases and acting as a guanine nucleotide exchange
CC factor (GEF). This activation results in actin cytoskeleton
CC rearrangements and stimulates membrane ruffling, thus promoting
CC bacterial entry into non-phagocytic cells.
CC {ECO:0000256|ARBA:ARBA00024989, ECO:0000256|PIRNR:PIRNR034781}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|PIRNR:PIRNR034781}.
CC Note=Secreted via the bsa type III secretion system.
CC {ECO:0000256|PIRNR:PIRNR034781}.
CC -!- SIMILARITY: Belongs to the GEF (guanine exchange factor) SopE family.
CC {ECO:0000256|ARBA:ARBA00006320, ECO:0000256|PIRNR:PIRNR034781}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE016825; AAQ57975.1; -; Genomic_DNA.
DR RefSeq; WP_011133851.1; NC_005085.1.
DR AlphaFoldDB; Q7P1B7; -.
DR STRING; 243365.CV_0296; -.
DR KEGG; cvi:CV_0296; -.
DR eggNOG; ENOG5033HJR; Bacteria.
DR HOGENOM; CLU_1150266_0_0_4; -.
DR OrthoDB; 8595984at2; -.
DR Proteomes; UP000001424; Chromosome.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0030036; P:actin cytoskeleton organization; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.4120.10; SopE-like, GEF domain; 1.
DR InterPro; IPR005414; SopE.
DR InterPro; IPR035949; SopE-like_GEF_dom_sf.
DR InterPro; IPR016019; SopE_GEF_dom.
DR Pfam; PF07487; SopE_GEF; 1.
DR PIRSF; PIRSF034781; SecIII_sopE; 1.
DR PRINTS; PR01593; SOPEPROTEIN.
DR SUPFAM; SSF81832; SopE-like GEF domain; 1.
PE 3: Inferred from homology;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468,
KW ECO:0000256|PIRNR:PIRNR034781};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PIRNR:PIRNR034781};
KW Reference proteome {ECO:0000313|Proteomes:UP000001424};
KW Secreted {ECO:0000256|ARBA:ARBA00022525, ECO:0000256|PIRNR:PIRNR034781};
KW Virulence {ECO:0000256|ARBA:ARBA00023026, ECO:0000256|PIRNR:PIRNR034781}.
FT DOMAIN 107..240
FT /note="Guanine nucleotide exchange factor SopE GEF"
FT /evidence="ECO:0000259|Pfam:PF07487"
SQ SEQUENCE 241 AA; 26180 MW; 08686C8FC00E4821 CRC64;
MKIGVLNAGL RQFAAEFGER AARAGRGLAG MFRRAANVAE AAPRRSAAAI EQGWQRFSAR
FLGARGADKP APTTLTRGGA ARSPLSPGDV KAMIRSRLDS LRDGMADPVY RRQALESTYA
TIYSEAKQAF YRANGGKMPE GYLRELGEAA RAAGLPGENK HGVFIPSGDG ASPFVNYLLI
PVQKEFGHRL RNESQQRLFR DFARQLSMEL VAPHAAERGW EPPAAFAARL EAVGRPWLAQ
A
//
