ID Q7PPF5_ANOGA Unreviewed; 684 AA.
AC Q7PPF5;
DT 15-DEC-2003, integrated into UniProtKB/TrEMBL.
DT 07-DEC-2004, sequence version 2.
DT 27-MAR-2024, entry version 116.
DE SubName: Full=AGAP004981-PA {ECO:0000313|EMBL:EAA10495.3};
GN Name=PPO4 {ECO:0000313|EMBL:EAA10495.3};
GN Synonyms=1275806 {ECO:0000313|EnsemblMetazoa:AGAP004981-PA};
GN ORFNames=AgaP_AGAP004981 {ECO:0000313|EMBL:EAA10495.3};
OS Anopheles gambiae (African malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7165 {ECO:0000313|EMBL:EAA10495.3};
RN [1] {ECO:0000313|EMBL:EAA10495.3, ECO:0000313|Proteomes:UP000007062}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PEST {ECO:0000313|EMBL:EAA10495.3,
RC ECO:0000313|Proteomes:UP000007062};
RX PubMed=12364791; DOI=10.1126/science.1076181;
RA Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA Collins F.H., Hoffman S.L.;
RT "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL Science 298:129-149(2002).
RN [2] {ECO:0000313|EMBL:EAA10495.3}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA10495.3};
RG The Anopheles Genome Sequencing Consortium;
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:EAA10495.3}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA10495.3};
RX PubMed=14747013; DOI=10.1016/j.pt.2003.11.003;
RA Mongin E., Louis C., Holt R.A., Birney E., Collins F.H.;
RT "The Anopheles gambiae genome: an update.";
RL Trends Parasitol. 20:49-52(2004).
RN [4] {ECO:0000313|EMBL:EAA10495.3}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA10495.3};
RX PubMed=17210077; DOI=10.1186/gb-2007-8-1-r5;
RA Sharakhova M.V., Hammond M.P., Lobo N.F., Krzywinski J., Unger M.F.,
RA Hillenmeyer M.E., Bruggner R.V., Birney E., Collins F.H.;
RT "Update of the Anopheles gambiae PEST genome assembly.";
RL Genome Biol. 8:R5.1-R5.13(2007).
RN [5] {ECO:0000313|EMBL:EAA10495.3}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA10495.3};
RG VectorBase;
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [6] {ECO:0000313|EnsemblMetazoa:AGAP004981-PA}
RP IDENTIFICATION.
RC STRAIN=PEST {ECO:0000313|EnsemblMetazoa:AGAP004981-PA};
RG EnsemblMetazoa;
RL Submitted (JAN-2021) to UniProtKB.
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DR EMBL; AAAB01008948; EAA10495.3; -; Genomic_DNA.
DR RefSeq; XP_315084.2; XM_315084.3.
DR AlphaFoldDB; Q7PPF5; -.
DR STRING; 7165.Q7PPF5; -.
DR PaxDb; 7165-AGAP004981-PA; -.
DR EnsemblMetazoa; AGAP004981-RA; AGAP004981-PA; AGAP004981.
DR GeneID; 1275806; -.
DR KEGG; aga:AgaP_AGAP004981; -.
DR CTD; 1275806; -.
DR VEuPathDB; VectorBase:AGAP004981; -.
DR eggNOG; ENOG502S0I4; Eukaryota.
DR HOGENOM; CLU_012213_0_1_1; -.
DR InParanoid; Q7PPF5; -.
DR OMA; TFPSKFV; -.
DR OrthoDB; 5406463at2759; -.
DR Proteomes; UP000007062; Chromosome 2L.
DR ExpressionAtlas; Q7PPF5; differential.
DR GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR Gene3D; 1.10.1280.10; Di-copper center containing domain from catechol oxidase; 1.
DR Gene3D; 2.60.40.1520; Hemocyanin, C-terminal domain; 1.
DR Gene3D; 1.20.1370.10; Hemocyanin, N-terminal domain; 1.
DR InterPro; IPR008922; Di-copper_centre_dom_sf.
DR InterPro; IPR013788; Hemocyanin/hexamerin.
DR InterPro; IPR000896; Hemocyanin/hexamerin_mid_dom.
DR InterPro; IPR005203; Hemocyanin_C.
DR InterPro; IPR037020; Hemocyanin_C_sf.
DR InterPro; IPR005204; Hemocyanin_N.
DR InterPro; IPR036697; Hemocyanin_N_sf.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002227; Tyrosinase_Cu-bd.
DR PANTHER; PTHR11511:SF24; GH04080P; 1.
DR PANTHER; PTHR11511; LARVAL STORAGE PROTEIN/PHENOLOXIDASE; 1.
DR Pfam; PF03723; Hemocyanin_C; 1.
DR Pfam; PF00372; Hemocyanin_M; 1.
DR Pfam; PF03722; Hemocyanin_N; 1.
DR PRINTS; PR00187; HAEMOCYANIN.
DR SUPFAM; SSF48056; Di-copper centre-containing domain; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF48050; Hemocyanin, N-terminal domain; 1.
DR PROSITE; PS00209; HEMOCYANIN_1; 1.
DR PROSITE; PS00210; HEMOCYANIN_2; 1.
DR PROSITE; PS00498; TYROSINASE_2; 1.
PE 4: Predicted;
KW Monooxygenase {ECO:0000256|ARBA:ARBA00023033};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023033};
KW Reference proteome {ECO:0000313|Proteomes:UP000007062}.
FT DOMAIN 398..409
FT /note="Tyrosinase copper-binding"
FT /evidence="ECO:0000259|PROSITE:PS00498"
SQ SEQUENCE 684 AA; 78476 MW; FCA22D3497ED4A42 CRC64;
MTDINTRFRG LLQRPYEPTF VPKNNGQLYF DVPDSYLTDH YRPFGAALQN RFGTNAQTRI
PLPNITAPDL AYADAVSRRG GFSIFHPSHQ RVASQLIELF LEQSNPDALT AMAVFVRDRV
NGPLFQYALS VALMHRTDTR DVEIPSFLEL FPDRYVDPAV FPQLREEGTL VDQGDRRAIE
IPMNFTASDR VDEQRLAYWR EDIGVNLHHW HWHLVYPARG PDRIVRKDRR GELFYYMHQQ
TMARYNIERF ANGMPRVVAF RNFREAIPEA YFPKITRSSD GRSYPARHPN ETLSDLKRVE
DGVIVSIADM ELWTTRIFEA IDNGFAQSSS NQRVPLDNDS GIDLLGNIVE ASTLSVNPQY
YGDLHNNGHN ILGYIHDPDN SFLEGFGVVG DNTTAMRDPV FYRWHQHIDD IFVRHKQRLP
AYTGQELAFN DVAVDSFEIQ LNKANAPVNI LLTFWQRSQV NLGTGLDFGP EGNLFATFTH
IQHAPYSYRI RVNNRAGDTR RGTVRIFFGP KTNERGQTLP FREQRRLMVE LDKFTVTLNA
GANTIVRRSD QSSVSIPYER TFRNVAASSL TQNEAFQFCN CGWPNHMLLP KGSPDGIEYD
FFVMVSDFAQ DRVEDFDENV NCNDAHSFCG LRDRRYPDSR SMGYPFDRFT PGTIGSLLDF
TKPYVNMLVT PVKIRFTNTV IARA
//
