ID Q7PT23_ANOGA Unreviewed; 153 AA.
AC Q7PT23; Q4ZJA5;
DT 15-DEC-2003, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2007, sequence version 3.
DT 27-MAR-2024, entry version 135.
DE SubName: Full=AGAP007386-PA {ECO:0000313|EMBL:EAA04667.4};
DE SubName: Full=Lysozyme c-7 {ECO:0000313|EMBL:AAY21240.1};
GN Name=LYSC7 {ECO:0000313|EMBL:EAA04667.4};
GN Synonyms=1269796 {ECO:0000313|EnsemblMetazoa:AGAP007386-PA};
GN ORFNames=AgaP_AGAP007386 {ECO:0000313|EMBL:EAA04667.4};
OS Anopheles gambiae (African malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7165 {ECO:0000313|EMBL:EAA04667.4};
RN [1] {ECO:0000313|EMBL:EAA04667.4, ECO:0000313|Proteomes:UP000007062}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PEST {ECO:0000313|EMBL:EAA04667.4,
RC ECO:0000313|Proteomes:UP000007062};
RX PubMed=12364791; DOI=10.1126/science.1076181;
RA Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA Collins F.H., Hoffman S.L.;
RT "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL Science 298:129-149(2002).
RN [2] {ECO:0000313|EMBL:EAA04667.4}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA04667.4};
RG The Anopheles Genome Sequencing Consortium;
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:EAA04667.4}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA04667.4};
RX PubMed=14747013; DOI=10.1016/j.pt.2003.11.003;
RA Mongin E., Louis C., Holt R.A., Birney E., Collins F.H.;
RT "The Anopheles gambiae genome: an update.";
RL Trends Parasitol. 20:49-52(2004).
RN [4] {ECO:0000313|EMBL:AAY21240.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=G3 {ECO:0000313|EMBL:AAY21240.1};
RX PubMed=16137842; DOI=10.1016/j.gene.2005.07.001;
RA Li B., Calvo E., Marinotti O., James A.A., Paskewitz S.M.;
RT "Characterization of the c-type lysozyme gene family in Anopheles
RT gambiae.";
RL Gene 360:131-139(2005).
RN [5] {ECO:0000313|EMBL:EAA04667.4}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA04667.4};
RX PubMed=17210077; DOI=10.1186/gb-2007-8-1-r5;
RA Sharakhova M.V., Hammond M.P., Lobo N.F., Krzywinski J., Unger M.F.,
RA Hillenmeyer M.E., Bruggner R.V., Birney E., Collins F.H.;
RT "Update of the Anopheles gambiae PEST genome assembly.";
RL Genome Biol. 8:R5.1-R5.13(2007).
RN [6] {ECO:0000313|EMBL:EAA04667.4}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA04667.4};
RG VectorBase;
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [7] {ECO:0000313|EnsemblMetazoa:AGAP007386-PA}
RP IDENTIFICATION.
RC STRAIN=PEST {ECO:0000313|EnsemblMetazoa:AGAP007386-PA};
RG EnsemblMetazoa;
RL Submitted (JAN-2021) to UniProtKB.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 22 family.
CC {ECO:0000256|RuleBase:RU004440}.
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DR EMBL; DQ004401; AAY21240.1; -; mRNA.
DR EMBL; AAAB01008807; EAA04667.4; -; Genomic_DNA.
DR RefSeq; XP_308446.3; XM_308446.4.
DR AlphaFoldDB; Q7PT23; -.
DR CAZy; GH22; Glycoside Hydrolase Family 22.
DR PaxDb; 7165-AGAP007386-PA; -.
DR EnsemblMetazoa; AGAP007386-RA; AGAP007386-PA; AGAP007386.
DR GeneID; 1269796; -.
DR KEGG; aga:AgaP_AGAP007386; -.
DR CTD; 1269796; -.
DR VEuPathDB; VectorBase:AGAP007386; -.
DR eggNOG; ENOG502RZU4; Eukaryota.
DR HOGENOM; CLU_111620_2_0_1; -.
DR InParanoid; Q7PT23; -.
DR OMA; LPDIANC; -.
DR OrthoDB; 5361006at2759; -.
DR Proteomes; UP000007062; Chromosome 2L.
DR GO; GO:0003796; F:lysozyme activity; IBA:GO_Central.
DR CDD; cd16899; LYZ_C_invert; 1.
DR Gene3D; 1.10.530.10; -; 1.
DR InterPro; IPR001916; Glyco_hydro_22.
DR InterPro; IPR019799; Glyco_hydro_22_CS.
DR InterPro; IPR000974; Glyco_hydro_22_lys.
DR InterPro; IPR023346; Lysozyme-like_dom_sf.
DR PANTHER; PTHR11407:SF74; GEO08277P1-RELATED; 1.
DR PANTHER; PTHR11407; LYSOZYME C; 1.
DR Pfam; PF00062; Lys; 1.
DR PRINTS; PR00137; LYSOZYME.
DR PRINTS; PR00135; LYZLACT.
DR SMART; SM00263; LYZ1; 1.
DR SUPFAM; SSF53955; Lysozyme-like; 1.
DR PROSITE; PS00128; GLYCOSYL_HYDROL_F22_1; 1.
DR PROSITE; PS51348; GLYCOSYL_HYDROL_F22_2; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000007062};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..30
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 31..153
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014587893"
FT DOMAIN 100..118
FT /note="Glycosyl hydrolases family 22 (GH22)"
FT /evidence="ECO:0000259|PROSITE:PS00128"
SQ SEQUENCE 153 AA; 16849 MW; E5CB2156BA6351CA CRC64;
MAAKRVSVRQ TLSLAIVSLC LLGLPSLIDA KIYTKCELAK QLTANGISRT YQGHWVCLAI
AVSGLDTTKT TMLPNLTANY GIFQINSKEW CRVGYKGGKC NMKCEDLVTD DITNAIKCSK
IIQQQNGFNE WVMWQKKCKG KELPDIANCA AIG
//
