ID Q7Q2A2_ANOGA Unreviewed; 1908 AA.
AC Q7Q2A2;
DT 15-DEC-2003, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 5.
DT 27-MAR-2024, entry version 126.
DE SubName: Full=AGAP003944-PA {ECO:0000313|EMBL:EAA13654.5};
GN ORFNames=AgaP_AGAP003944 {ECO:0000313|EMBL:EAA13654.5};
OS Anopheles gambiae (African malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7165 {ECO:0000313|EMBL:EAA13654.5};
RN [1] {ECO:0000313|EMBL:EAA13654.5}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PEST {ECO:0000313|EMBL:EAA13654.5};
RX PubMed=12364791; DOI=10.1126/science.1076181;
RA Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA Collins F.H., Hoffman S.L.;
RT "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL Science 298:129-149(2002).
RN [2] {ECO:0000313|EMBL:EAA13654.5}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA13654.5};
RG The Anopheles Genome Sequencing Consortium;
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:EAA13654.5}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA13654.5};
RX PubMed=14747013; DOI=10.1016/j.pt.2003.11.003;
RA Mongin E., Louis C., Holt R.A., Birney E., Collins F.H.;
RT "The Anopheles gambiae genome: an update.";
RL Trends Parasitol. 20:49-52(2004).
RN [4] {ECO:0000313|EMBL:EAA13654.5}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA13654.5};
RX PubMed=17210077; DOI=10.1186/gb-2007-8-1-r5;
RA Sharakhova M.V., Hammond M.P., Lobo N.F., Krzywinski J., Unger M.F.,
RA Hillenmeyer M.E., Bruggner R.V., Birney E., Collins F.H.;
RT "Update of the Anopheles gambiae PEST genome assembly.";
RL Genome Biol. 8:R5.1-R5.13(2007).
RN [5] {ECO:0000313|EMBL:EAA13654.5}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA13654.5};
RG VectorBase;
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAA13654.5}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAAB01008978; EAA13654.5; -; Genomic_DNA.
DR RefSeq; XP_318402.5; XM_318402.5.
DR STRING; 7165.Q7Q2A2; -.
DR PaxDb; 7165-AGAP003944-PA; -.
DR GeneID; 1278773; -.
DR KEGG; aga:AgaP_AGAP003944; -.
DR VEuPathDB; VectorBase:AGAP003944; -.
DR eggNOG; KOG1452; Eukaryota.
DR HOGENOM; CLU_002292_0_0_1; -.
DR OMA; NQHGNHR; -.
DR OrthoDB; 2905108at2759; -.
DR PhylomeDB; Q7Q2A2; -.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd00030; C2; 1.
DR CDD; cd00992; PDZ_signaling; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR46150; RHO GTPASE-ACTIVATING PROTEIN 100F; 1.
DR PANTHER; PTHR46150:SF3; RHO GTPASE-ACTIVATING PROTEIN 100F; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00239; C2; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
FT DOMAIN 142..212
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 753..877
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 917..1117
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 1..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 225..300
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 446..490
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 673..699
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1117..1188
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1211..1246
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1271..1381
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1466..1529
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1567..1586
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1764..1811
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1835..1908
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 27..62
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 248..288
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 681..699
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1147..1188
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1297..1323
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1330..1381
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1466..1504
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1782..1811
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1857..1898
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1908 AA; 199061 MW; BFA4F556096D994A CRC64;
MDRENGRSVP DLTASPGRAP PGPMPSHQAQ ALQQQQQQQH QQQGLQGHHQ QQQQQQRQGS
KEPVLLQGDF RKVSGISSEI FRQIEAVEND HDPSTAAALE VVERRGEMIV RILEPRCMGS
RQAIEAGQKF LNKSDARHTV QLVEIVKRPG QTLGLYIREG NGADRSDGVF ISRIALESAV
YNSGCLRVGD EILAVNLVDV TRMSLDDVVI IMSIPRRLVL AIRQRRGNRG SNSPGPPQMS
RPEQKPPPVV VIKRDLRDED LDDSDRAPRS SRSSRERRTG DGREMTESRS RLGLGLNNYS
PQSEQLDLYY GAGRGPGGGP GPAETPNWGY KPPAPPSSVI TEQPKGMHGG FQTSHSYYQN
AGTLESLAEK VHAFYPSATT SRRMSAGPAG VAMSQSHQRF PRSGSDQHLP RVEYADYASL
GRHPLLARSS LKSDLVGAAP IAGGTLGRYG RYDAPPPQPR APKYGPSPLG ATGSLQRRSR
PALDYSSDTE ATIGPRPSYY YYNHPAMAAS GTMGGRGSTQ ALGGGPEFAK FNSLPRERPG
ATRLGLRGRI TDRLQDEADG NVSAPEYSLP IRRDIRDLRN RITASPSIFT SDEYRAWLRR
APSSSAICEQ MRASRDLLNQ QRAHRFSCSA ENIHDVLKNT EHIYSSRTGL GMGGAGAGGG
VVGGTLDRHS MAAGGPRMSS LPVRSLSSQH IGGPSSIRSP SVRRMRQLLE LTQGAGVGGV
PGSVVAALTG HQSPAPTPST TLPRAHRQID INPAEYTKYK LDKPVVDAVG MSGMLWIHLL
AGRGLRAMSE TSQIQQPLIR DLYCVLECDR IHKARTVVRS GDLQFDWDES FELDLVCNKQ
LDVLVYSWDP QHRHKLCYRG ALSLTTLLRQ SPIHQLALKV EPRGTIYLRL RHTDPFQLFR
RRGLPSLRGN VPALFGADLE TVVTRESKGA PGCAPVPIIL RRCVEEVERR GLDIIGLYRL
CGSATKKRLL REAFERNSRA VELTPEHVPD INVITGVLKD YLRELPEPLF TKCLFQMTVD
ALGVCLPDDP EGNAKLMLSI LDCLPRANRA TLVFLLDHLS LVVSAAERNK MSAQALATAL
GPPLMLHSAS VGANEEIDHA QPIAVLKYLL QIWPQPGTGT GAPTSGNTGR RGEPVEPRGN
KASALQAGKS AALQQQQQQQ LGSTISHRSS SSSNIQQQLR STSSTNLAAT SSSISSSISS
SSSIISRSPH ALASSSSSSN IQSSVPPSIQ PRTAANNPST TSSTLGQHLL SATPSTLQYQ
SVVAQLAQSH RALQQAGQQP HPSEVSAGLA ERVQSPHHAT PSPSSSSTSS ASGSGSGTDT
IKRGASPASV KFKESTSNYS LKSDTQSRIL GGARQHSQQP SYTTAGGASI SSSNGGNGGS
AAGATSYDLL HARTGGLFAS SAGTDYLSST SSIASSIASS AAGAGAATSA AGLYGKVGGG
AAATSAPLTS TLNITTFSLD EKNNLVVSPS PSSASESSYR SSSPASSIQR DKSPNKSSGS
PSPLRRQDPL DRADSLPSTG ATSGSGTSAA STVAATTASS GAGSFMSSLR SQTLGSYQFP
STSLKLTSQL SSGSSGQDAS DDGSTSSLLR KLTSSLSRTI VSNTGTLPLS LGREKLAELS
STAGGGTGAT AGSGSTGAYS SSSGIGSISS SISSSIGSSN ASGSGLRTMS TSLGYSGIGG
GASALDGGAG GAGGSSSGSS SVTTAAAVTS MNIYGTLPKN SSIYSSYGVG SGTSVSGSSG
SGLSGLLSGT TSSYGISERL RALTSGGSVG DGAADRSTGG VESAGGTGSS AGDLESSGYD
YESSGFSSAS YSGMATSGAS IGSGGGLSSS YFSTGSNSSP FATMSGGGGG GGRAGDSGTG
STATDTNPYR VQYSSTNPFL PSFNPTSDGS NGRADSKTSN GDEPFDMK
//
