ID Q7Q4D9_ANOGA Unreviewed; 1148 AA.
AC Q7Q4D9;
DT 15-DEC-2003, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2007, sequence version 3.
DT 27-MAR-2024, entry version 155.
DE SubName: Full=AGAP008354-PA {ECO:0000313|EMBL:EAA12165.3};
GN ORFNames=AgaP_AGAP008354 {ECO:0000313|EMBL:EAA12165.3};
OS Anopheles gambiae (African malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7165 {ECO:0000313|EMBL:EAA12165.3};
RN [1] {ECO:0000313|EMBL:EAA12165.3}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PEST {ECO:0000313|EMBL:EAA12165.3};
RX PubMed=12364791; DOI=10.1126/science.1076181;
RA Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA Collins F.H., Hoffman S.L.;
RT "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL Science 298:129-149(2002).
RN [2] {ECO:0000313|EMBL:EAA12165.3}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA12165.3};
RG The Anopheles Genome Sequencing Consortium;
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:EAA12165.3}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA12165.3};
RX PubMed=14747013; DOI=10.1016/j.pt.2003.11.003;
RA Mongin E., Louis C., Holt R.A., Birney E., Collins F.H.;
RT "The Anopheles gambiae genome: an update.";
RL Trends Parasitol. 20:49-52(2004).
RN [4] {ECO:0000313|EMBL:EAA12165.3}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA12165.3};
RX PubMed=17210077; DOI=10.1186/gb-2007-8-1-r5;
RA Sharakhova M.V., Hammond M.P., Lobo N.F., Krzywinski J., Unger M.F.,
RA Hillenmeyer M.E., Bruggner R.V., Birney E., Collins F.H.;
RT "Update of the Anopheles gambiae PEST genome assembly.";
RL Genome Biol. 8:R5.1-R5.13(2007).
RN [5] {ECO:0000313|EMBL:EAA12165.3}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA12165.3};
RG VectorBase;
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAA12165.3}.
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DR EMBL; AAAB01008964; EAA12165.3; -; Genomic_DNA.
DR RefSeq; XP_317101.3; XM_317101.4.
DR AlphaFoldDB; Q7Q4D9; -.
DR STRING; 7165.Q7Q4D9; -.
DR PaxDb; 7165-AGAP008354-PA; -.
DR GeneID; 1277627; -.
DR KEGG; aga:AgaP_AGAP008354; -.
DR VEuPathDB; VectorBase:AGAP008354; -.
DR eggNOG; KOG0197; Eukaryota.
DR HOGENOM; CLU_008155_2_1_1; -.
DR PhylomeDB; Q7Q4D9; -.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004713; F:protein tyrosine kinase activity; IEA:InterPro.
DR CDD; cd00192; PTKc; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 2.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR InterPro; IPR020635; Tyr_kinase_cat_dom.
DR PANTHER; PTHR45807; TYROSINE-PROTEIN KINASE HOPSCOTCH; 1.
DR PANTHER; PTHR45807:SF7; TYROSINE-PROTEIN KINASE HOPSCOTCH; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 2.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00219; TyrKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 2.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 2.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999}.
FT DOMAIN 11..340
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT DOMAIN 481..767
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 874..1140
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 819..838
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 906
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 1148 AA; 132378 MW; 96531579913F79FC CRC64;
MPDEAAYQVF NYVADCFIHV PVVGRAGGED DTCERVCRAV CEQLKIKPVV FALVGLRLHD
EKWFPAGSRP STDKKYDFRL RFKVPDLSCL KALDQELFNY YYSQLRYDLL HNRIPEIDYR
KYKNKILGYV VNDMYRKMIE DKVGLSELKR DFEKYIPRKI SREHSVCFVN VAQKRIFESL
NSIQNRDHDV NYVKNVYIND IDNIAPGYLY EEYAAEIQYP RGEFSSRTGK CPVKLRFQPY
GTAVSSRETT KYGSTGGGLE RTLDHEDATT TPGLKVFYAS KWQHVTNIDE ILTILVEKLT
VKLALEDQSE PYCIDFHDQT ELNSFVTCLA GYYRLMCKWT VYLCQDYLSS PMLNLLKELK
CHGPIGGKYS TDKIREKNSS CGACIIRQCE EQYDTYYVDM LETDGLIKTY KLIHAEDQWH
VQRDKEEEEA LHRYNQLTEA LKSLNPEITS VYRLPPSDND TAPNLLLCRP THKASPKRLL
RGGTQELGQK RACIINAAKE LVINRNAVED ESDGYTKRTR ADFLLPNNSK MEVTLKLLKN
EKEGEYLKDF LQVAGQWATI DSIDIIKLYG MTVCKPITMV LEFPRYGRLD EFLRTRRTSV
RPTALIEIGH SLARALYYLQ KHGIIHGHIR CSSMLVTQYD EGEQRVLAKL GDPGMHGQRR
LTKHDLLWIP YEYQDLSEQS VARLRADPAT DAWACTSTLW EIFSRGIKMH VYKPAEFLPT
RKWLQTMPPE LKDSKQIYEC LSCGWHADPD KRLAPQTVVG LLVHARQLDG SYCTVGNGHV
NGHSTSNMLN GSVFKNSILS METNSTLIRS RTDCTSSSYV SNGSDSELRS NASSGSSSLP
LLSNSINRFS GDSYYEKTFV NCSDYIQLSG SERIFFHNML GEGNYGRVYR GTLERDNQAP
RDVALKTIYD DRPDLGRVKD DFRREVDIMK NLRHTNIVEF ICFIEELDKL VVVMEYVPLG
SLLAYLGYMR YELKELDLLW MARDIANGMN YLCEKNIVHR DLAARNILVE SKKCVKISDF
GLAQVTEGSN YYVARHSREL PIRWYAPETL ETQKYSSQSD VWSFGVTLYE MFTYGATPYS
HVDVKSAAQL YQLLQRETKI LQLPEDFSYV YDKLMAPCFK RDPHERMTFS ELLEELNDMI
NQYGEPIY
//
