ID Q7QAF9_ANOGA Unreviewed; 1348 AA.
AC Q7QAF9;
DT 15-DEC-2003, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 5.
DT 08-NOV-2023, entry version 103.
DE SubName: Full=AGAP003714-PA {ECO:0000313|EMBL:EAA08795.5};
GN ORFNames=AgaP_AGAP003714 {ECO:0000313|EMBL:EAA08795.5};
OS Anopheles gambiae (African malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7165 {ECO:0000313|EMBL:EAA08795.5};
RN [1] {ECO:0000313|EMBL:EAA08795.5}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PEST {ECO:0000313|EMBL:EAA08795.5};
RX PubMed=12364791; DOI=10.1126/science.1076181;
RA Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA Collins F.H., Hoffman S.L.;
RT "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL Science 298:129-149(2002).
RN [2] {ECO:0000313|EMBL:EAA08795.5}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA08795.5};
RG The Anopheles Genome Sequencing Consortium;
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:EAA08795.5}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA08795.5};
RX PubMed=14747013; DOI=10.1016/j.pt.2003.11.003;
RA Mongin E., Louis C., Holt R.A., Birney E., Collins F.H.;
RT "The Anopheles gambiae genome: an update.";
RL Trends Parasitol. 20:49-52(2004).
RN [4] {ECO:0000313|EMBL:EAA08795.5}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA08795.5};
RX PubMed=17210077; DOI=10.1186/gb-2007-8-1-r5;
RA Sharakhova M.V., Hammond M.P., Lobo N.F., Krzywinski J., Unger M.F.,
RA Hillenmeyer M.E., Bruggner R.V., Birney E., Collins F.H.;
RT "Update of the Anopheles gambiae PEST genome assembly.";
RL Genome Biol. 8:R5.1-R5.13(2007).
RN [5] {ECO:0000313|EMBL:EAA08795.5}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA08795.5};
RG VectorBase;
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAA08795.5}.
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DR EMBL; AAAB01008888; EAA08795.5; -; Genomic_DNA.
DR RefSeq; XP_313514.5; XM_313514.5.
DR SMR; Q7QAF9; -.
DR PaxDb; 7165-AGAP003714-PA; -.
DR GeneID; 1274394; -.
DR KEGG; aga:AgaP_AGAP003714; -.
DR VEuPathDB; VectorBase:AGAP003714; -.
DR eggNOG; KOG2408; Eukaryota.
DR HOGENOM; CLU_004474_0_0_1; -.
DR InParanoid; Q7QAF9; -.
DR OMA; HEDVCFR; -.
DR OrthoDB; 4560at2759; -.
DR PhylomeDB; Q7QAF9; -.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004601; F:peroxidase activity; IBA:GO_Central.
DR GO; GO:0006979; P:response to oxidative stress; IEA:InterPro.
DR CDD; cd09823; peroxinectin_like; 1.
DR Gene3D; 1.10.640.10; Haem peroxidase domain superfamily, animal type; 1.
DR InterPro; IPR019791; Haem_peroxidase_animal.
DR InterPro; IPR010255; Haem_peroxidase_sf.
DR InterPro; IPR037120; Haem_peroxidase_sf_animal.
DR PANTHER; PTHR11475:SF109; CHORION PEROXIDASE-LIKE PROTEIN; 1.
DR PANTHER; PTHR11475; OXIDASE/PEROXIDASE; 1.
DR Pfam; PF03098; An_peroxidase; 1.
DR PRINTS; PR00457; ANPEROXIDASE.
DR SUPFAM; SSF48113; Heme-dependent peroxidases; 1.
DR PROSITE; PS50292; PEROXIDASE_3; 1.
PE 4: Predicted;
KW Heme {ECO:0000256|PIRSR:PIRSR619791-2};
KW Iron {ECO:0000256|PIRSR:PIRSR619791-2};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR619791-2}.
FT REGION 665..726
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 772..885
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 899..1016
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1219..1288
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 676..695
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 696..726
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 772..797
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 819..852
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 853..868
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 920..957
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 978..1016
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1225..1268
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1269..1284
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 427
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="axial binding residue"
FT /evidence="ECO:0000256|PIRSR:PIRSR619791-2"
SQ SEQUENCE 1348 AA; 150319 MW; C58BAA2505278F23 CRC64;
MQLALQSAAR KGLEAMIELY DRAEPNLLKR GAVLDANDPG ALLAQFSASN QTEMDAKAAY
ATLIAAKTFK ESTNVEYFAL GRQAPPKISL KKTPLEKLCP SREAPRCVPA SLRYRTHDGT
CNNVRRPRWG SAQMPFHRFL APEYQDGVEG IRRSVTGATL PSARFVSLVV HGSRNEEAPV
TMMLALWGQL IDHDITATSQ PRSINGSTPR CCNGGEESTH PSCLPIKVPQ DDPWLSHLGV
RCLEFLRSAP AQRRDCLLSW REQTNQATSF LDASPIYSSN PRSSDNARIF RNGMLLFGRG
PPHEDVCFRA ALANQCIRPG DSRSGEQPGL LMMHMIWVNE HNQIATRLAD INPHWSDEKV
YQETRRIVGA LFQHITYREF LPLVLGKEVC RLFDLELETS GYYRNYDANV NPTVANEFSA
AAFRFGHSLI QSTYMRADRH HRFIANNVSL HEDTSEGDFG GPGSLHRLLR GMVNQRALKR
DEFITAELTN HLFQTKSFPF GLDLAAINIQ RGRDHGLPAY VNWRGPCGLS TIKDWSDLER
VMGPASTNRL RKAYRTIDDI DLFVGGLAER PVVGGIVGPT FSCIIAQQFS NLRKGDRFWY
ENPGFESSFT PAQLESIRQI GFAQVLCRAL GGGGTLQPFV FLPADFGQNE RLSCESRLMA
PIDLTPWKER DPFNNDTGDE DEDEDEDDED DDEATVANGT ASTTDLETAQ SSTFSSTTTT
TRRPTLVAET SSNVINKVDL ITNGNTGVQP NRQRPQSSTL TVGPTVIISN KVDFTPSTST
RPKPTAQSST ATAIDNKLDL KVTTKPTPKR KPTRKPTTKK RPTTSSATKP LVTSNLDFSR
NANGTVTSDA DTTERLARTK RATTKVREQE ARYGYYQTPA PPTDYSDYDE DYNTDYDKPP
PYLAYGYHRP TTKTTTTTTT TQPPPPPYGY YPPYGGGYYT APPTPPPPPP PPNPYFDTRR
PLRTTTPRRR LSDKLTLNVD APQHNAPQRP RTSTFRPPTD NNPHKTPSNK PFKPSSLAQT
SVFSVDFKSL PTAGRSLSTN SSAALNDTVL FATAINTTLS KDDSTVLSRT TATRSGVSTS
GDLPMKLSES FSIYDYDNDY DDAVPNPTRH TSTTTNDNDS DRLTILPLDE HDGYLRPEQT
HFEPLVRPSV VSTGQTYRNY YGTNETTQTI HYADYMNGRT SGPLYRDATE NYHRYAPAHH
EQLLLDDYSD KYVGLLLNGG KRDKDNGSTL TRTKHNRPRM IDGDDWTGKD SQPDQRAIRD
DTGKDRRTSV TKQKHKRPTN HRLKTSTKKP SAISLVPFVL LTSIDRPDNW VMYHSKPSKH
RKPPAAVPLL KSDTFSLSEF PTPIADPD
//
