ID Q7QHH1_ANOGA Unreviewed; 1360 AA.
AC Q7QHH1;
DT 15-DEC-2003, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 4.
DT 27-MAR-2024, entry version 144.
DE SubName: Full=AGAP011186-PA {ECO:0000313|EMBL:EAA05071.4};
DE Flags: Fragment;
GN Name=TOLL11 {ECO:0000313|EMBL:EAA05071.4};
GN ORFNames=AgaP_AGAP011186 {ECO:0000313|EMBL:EAA05071.4};
OS Anopheles gambiae (African malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7165 {ECO:0000313|EMBL:EAA05071.4};
RN [1] {ECO:0000313|EMBL:EAA05071.4}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PEST {ECO:0000313|EMBL:EAA05071.4};
RX PubMed=12364791; DOI=10.1126/science.1076181;
RA Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA Collins F.H., Hoffman S.L.;
RT "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL Science 298:129-149(2002).
RN [2] {ECO:0000313|EMBL:EAA05071.4}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA05071.4};
RG The Anopheles Genome Sequencing Consortium;
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:EAA05071.4}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA05071.4};
RX PubMed=14747013; DOI=10.1016/j.pt.2003.11.003;
RA Mongin E., Louis C., Holt R.A., Birney E., Collins F.H.;
RT "The Anopheles gambiae genome: an update.";
RL Trends Parasitol. 20:49-52(2004).
RN [4] {ECO:0000313|EMBL:EAA05071.4}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA05071.4};
RX PubMed=17210077; DOI=10.1186/gb-2007-8-1-r5;
RA Sharakhova M.V., Hammond M.P., Lobo N.F., Krzywinski J., Unger M.F.,
RA Hillenmeyer M.E., Bruggner R.V., Birney E., Collins F.H.;
RT "Update of the Anopheles gambiae PEST genome assembly.";
RL Genome Biol. 8:R5.1-R5.13(2007).
RN [5] {ECO:0000313|EMBL:EAA05071.4}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA05071.4};
RG VectorBase;
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAA05071.4}.
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DR EMBL; AAAB01008816; EAA05071.4; -; Genomic_DNA.
DR RefSeq; XP_309461.4; XM_309461.2.
DR STRING; 7165.Q7QHH1; -.
DR PaxDb; 7165-AGAP011186-PA; -.
DR GeneID; 1270742; -.
DR KEGG; aga:AgaP_AGAP011186; -.
DR CTD; 1270742; -.
DR VEuPathDB; VectorBase:AGAP011186; -.
DR eggNOG; KOG4641; Eukaryota.
DR HOGENOM; CLU_004280_0_0_1; -.
DR OMA; HMRQYPR; -.
DR PhylomeDB; Q7QHH1; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 6.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000372; LRRNT.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24373; SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN; 1.
DR PANTHER; PTHR24373:SF397; TSUKUSHI; 1.
DR Pfam; PF13855; LRR_8; 6.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR00019; LEURICHRPT.
DR SMART; SM00364; LRR_BAC; 5.
DR SMART; SM00365; LRR_SD22; 8.
DR SMART; SM00369; LRR_TYP; 22.
DR SMART; SM00013; LRRNT; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF52047; RNI-like; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 5.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..1360
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5030176063"
FT TRANSMEM 1032..1056
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1088..1227
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT REGION 1261..1320
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1332..1360
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1280..1320
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1332..1350
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EAA05071.4"
SQ SEQUENCE 1360 AA; 153292 MW; C56B4A718A4E8076 CRC64;
ARTAEAAVHL LTLALLVGCC RSVDGRGNFL RHDETLPKAC SWTGAVLEVS QEKRSDELQC
RIKTITRTES LLANISSYQI DRIKSLKLEC NDIMFFESSL ESTTTPGNFL GNLHGLLRLS
IEYCKIKYIP ALAFANMRVL KRLALSTHNV DWSVMNLELH PDSFRGLTEL KEMHLADNNI
WSLPAEVFCP LQKLRVLNLT GNRLSDLTQL MLSDWGNGPT EPGRACNTGL EVLDLSGNDL
TLLPDNGLTA MRSLNALHLQ RNLLKEIADR AFVGLGTLEV LDLSDNRLTA LTPELFVSSR
KIRQVYLQNN SLSVLAPGVF EGLDRLETLD LSRNQLTSTW VKRDTFAGQV RLVVLNLGHN
QLSKVDQHVF KGLYSLQILN LEHNAIELLA DGAFSDLKNL HALFLSHNRL RQIEPYHFSE
LYVLNQLILE SNQIAYIHER AFENLTHLHD LSLNDNRLEE IPSGMKSLKF LQSLDLGKNQ
IAEINNSSFE GLEELMGLRL VDNQISEISR DTFFALSTIH VLNLASNRIR HIDQSAFSSN
PTLRAIRLDN NELEDVSGVF TSLSSLVYLN ISDNNIGWFD YSHYPQSLEW LDIHKNNISE
LGNRYDVGNW FQLKMLDVSH NKLRQINASS FPHNIETILM NNNHIEEIAP ETFTGKEHIV
KVVLYGNRLR RIEMSALALT PWPDTRMLPE FYLGDNLIHC DCTMEWLQRI NELAYLRQYP
QVKDLDSVHC SMEHERGEQR RPLMAMRASE FLCRYEAHCF ATCHCCDFDA CDCKMACPDR
CRCYHDTAWE SNIVDCGSAG LSLVPAKIPM DATDIYLDGN NLGALGSHVF IGKKKLKSLY
LNGSRIESLN NKTFAGIPAL EVLHLEQNGL EQLSGAEFEQ LRELKELYLH RNALASIGNR
SFYYQKSLEV LTIEENKLKG VRPWELLPLP SGGPDGAYRS VSLEGNALEC SCELLPKLLD
WLERMYRSNG SAAQSEEQTE SSEETSWGEF QCAGGKPLPD VVKECEGQRP AVVPVATATV
QRTIINDDFI DYLPLLIAVL AGLVLTIMLV ALVVLFRQDV CLWAHSRYGV RLCKDPLTAL
ERCEDSEKLY DAYLLYSAAD ADLVTSQIGQ ELEHHGYGMC LHYRDVHGGA GFLGDTVQSA
ADASRKLVLF VSVKFLQLEW SQPEFRAALQ AALELIRPSR RKQRIVLITS VPGSMLAMDP
IMDILARTCT VIAWDDRRFW DKLRFAMPDL GRDGGSVNKA SHRKNINIRY TPAPTNNLMV
QQQHPHHQQP YPVPQPRSLG GAHSTYTTED EEPSTAGSSP QYEAPTNPGS NFTNTNTLGH
VYSTIPEPQY MAEQQQLQQH QQQHRTGGTG PDGNNRPYFV
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