ID Q7QIF1_ANOGA Unreviewed; 292 AA.
AC Q7QIF1;
DT 15-DEC-2003, integrated into UniProtKB/TrEMBL.
DT 07-DEC-2004, sequence version 2.
DT 27-MAR-2024, entry version 83.
DE RecName: Full=Regulatory protein zeste {ECO:0000256|ARBA:ARBA00016807};
GN Name=1270251 {ECO:0000313|EnsemblMetazoa:AGAP006815-PA};
GN ORFNames=AgaP_AGAP006815 {ECO:0000313|EMBL:EAA04055.2};
OS Anopheles gambiae (African malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7165 {ECO:0000313|EMBL:EAA04055.2};
RN [1] {ECO:0000313|EMBL:EAA04055.2, ECO:0000313|Proteomes:UP000007062}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PEST {ECO:0000313|EMBL:EAA04055.2,
RC ECO:0000313|Proteomes:UP000007062};
RX PubMed=12364791; DOI=10.1126/science.1076181;
RA Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA Collins F.H., Hoffman S.L.;
RT "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL Science 298:129-149(2002).
RN [2] {ECO:0000313|EMBL:EAA04055.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA04055.2};
RG The Anopheles Genome Sequencing Consortium;
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:EAA04055.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA04055.2};
RX PubMed=14747013; DOI=10.1016/j.pt.2003.11.003;
RA Mongin E., Louis C., Holt R.A., Birney E., Collins F.H.;
RT "The Anopheles gambiae genome: an update.";
RL Trends Parasitol. 20:49-52(2004).
RN [4] {ECO:0000313|EMBL:EAA04055.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA04055.2};
RX PubMed=17210077; DOI=10.1186/gb-2007-8-1-r5;
RA Sharakhova M.V., Hammond M.P., Lobo N.F., Krzywinski J., Unger M.F.,
RA Hillenmeyer M.E., Bruggner R.V., Birney E., Collins F.H.;
RT "Update of the Anopheles gambiae PEST genome assembly.";
RL Genome Biol. 8:R5.1-R5.13(2007).
RN [5] {ECO:0000313|EMBL:EAA04055.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA04055.2};
RG VectorBase;
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [6] {ECO:0000313|EnsemblMetazoa:AGAP006815-PA}
RP IDENTIFICATION.
RC STRAIN=PEST {ECO:0000313|EnsemblMetazoa:AGAP006815-PA};
RG EnsemblMetazoa;
RL Submitted (JAN-2021) to UniProtKB.
CC -!- FUNCTION: Involved in transvection phenomena (= synapsis-dependent gene
CC expression), where the synaptic pairing of chromosomes carrying genes
CC with which zeste interacts influences the expression of these genes.
CC Zeste binds to DNA and stimulates transcription from a nearby promoter.
CC {ECO:0000256|ARBA:ARBA00025466}.
CC -!- SUBUNIT: Self-associates forming complexes of several hundred monomers.
CC {ECO:0000256|ARBA:ARBA00011764}.
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DR EMBL; AAAB01008807; EAA04055.2; -; Genomic_DNA.
DR RefSeq; XP_308932.2; XM_308932.3.
DR AlphaFoldDB; Q7QIF1; -.
DR STRING; 7165.Q7QIF1; -.
DR PaxDb; 7165-AGAP006815-PA; -.
DR EnsemblMetazoa; AGAP006815-RA; AGAP006815-PA; AGAP006815.
DR GeneID; 1270251; -.
DR KEGG; aga:AgaP_AGAP006815; -.
DR VEuPathDB; VectorBase:AGAP006815; -.
DR eggNOG; ENOG502SEZZ; Eukaryota.
DR HOGENOM; CLU_953839_0_0_1; -.
DR InParanoid; Q7QIF1; -.
DR OMA; NTINACQ; -.
DR OrthoDB; 3608205at2759; -.
DR Proteomes; UP000007062; Chromosome 2L.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR InterPro; IPR028002; Myb_DNA-bind_5.
DR Pfam; PF13873; Myb_DNA-bind_5; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Reference proteome {ECO:0000313|Proteomes:UP000007062}.
FT DOMAIN 46..85
FT /note="Myb/SANT-like DNA-binding"
FT /evidence="ECO:0000259|Pfam:PF13873"
FT REGION 123..177
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 123..146
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 149..177
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 292 AA; 32643 MW; 1DD02A9985DBCF60 CRC64;
MDAGPPPIIP AERRNSRINE DQLKRMVCML EKAPDIARAI ARGPQNVFWR RLAKELNDIG
PATKDPSSWK KVWHDYKCSV KKRLVQYNED ISSGIYPKQL SVLHRRILKL LDLDLKRVKI
TEESGSDRED ENNGTDADHS KDAFDMGDPM DSQSSTGAPG QEAAEDGTNR PASSSFSNTI
NACQQRLAKM PNITITKQKS DGDDDDPLSY CPKAATKSLP YGRGTKRKRE ECFEMALETN
RSLIAVMKTS LTVQKELVAE VRGLKKVLEE FTESMRELNG GLRNSGESTK GK
//
