ID Q7RYP8_NEUCR Unreviewed; 454 AA.
AC Q7RYP8;
DT 15-DEC-2003, integrated into UniProtKB/TrEMBL.
DT 23-OCT-2007, sequence version 2.
DT 27-MAR-2024, entry version 107.
DE RecName: Full=adenosine kinase {ECO:0000256|ARBA:ARBA00012119};
DE EC=2.7.1.20 {ECO:0000256|ARBA:ARBA00012119};
GN ORFNames=NCU00414 {ECO:0000313|EMBL:EAA28064.2};
OS Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS FGSC 987).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX NCBI_TaxID=367110 {ECO:0000313|EMBL:EAA28064.2, ECO:0000313|Proteomes:UP000001805};
RN [1] {ECO:0000313|EMBL:EAA28064.2, ECO:0000313|Proteomes:UP000001805}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987
RC {ECO:0000313|Proteomes:UP000001805};
RX PubMed=12712197; DOI=10.1038/nature01554;
RA Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.,
RA FitzHugh W., Ma L.J., Smirnov S., Purcell S., Rehman B., Elkins T.,
RA Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.,
RA Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA Kothe G.O., Jedd G., Mewes W., Staben C., Marcotte E., Greenberg D.,
RA Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA Kamal M., Kamvysselis M., Mauceli E., Bielke C., Rudd S., Frishman D.,
RA Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA Cogoni C., Macino G., Catcheside D., Li W., Pratt R.J., Osmani S.A.,
RA DeSouza C.P., Glass L., Orbach M.J., Berglund J.A., Voelker R., Yarden O.,
RA Plamann M., Seiler S., Dunlap J., Radford A., Aramayo R., Natvig D.O.,
RA Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S.,
RA Lander E.S., Nusbaum C., Birren B.;
RT "The genome sequence of the filamentous fungus Neurospora crassa.";
RL Nature 422:859-868(2003).
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- PATHWAY: Purine metabolism; AMP biosynthesis via salvage pathway; AMP
CC from adenosine: step 1/1. {ECO:0000256|ARBA:ARBA00004801}.
CC -!- SIMILARITY: Belongs to the carbohydrate kinase PfkB family.
CC {ECO:0000256|ARBA:ARBA00010688}.
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DR EMBL; CM002238; EAA28064.2; -; Genomic_DNA.
DR RefSeq; XP_957300.2; XM_952207.2.
DR AlphaFoldDB; Q7RYP8; -.
DR STRING; 367110.Q7RYP8; -.
DR PaxDb; 5141-EFNCRP00000000376; -.
DR EnsemblFungi; EAA28064; EAA28064; NCU00414.
DR GeneID; 3873447; -.
DR KEGG; ncr:NCU00414; -.
DR VEuPathDB; FungiDB:NCU00414; -.
DR HOGENOM; CLU_045832_1_1_1; -.
DR InParanoid; Q7RYP8; -.
DR OrthoDB; 22683at2759; -.
DR UniPathway; UPA00588; UER00659.
DR Proteomes; UP000001805; Chromosome 3, Linkage Group III.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0004001; F:adenosine kinase activity; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0044209; P:AMP salvage; IEA:UniProtKB-UniPathway.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0006144; P:purine nucleobase metabolic process; IBA:GO_Central.
DR GO; GO:0006166; P:purine ribonucleoside salvage; IEA:UniProtKB-KW.
DR CDD; cd01168; adenosine_kinase; 1.
DR Gene3D; 3.30.1110.10; -; 1.
DR Gene3D; 3.40.1190.20; -; 1.
DR InterPro; IPR001805; Adenokinase.
DR InterPro; IPR002173; Carboh/pur_kinase_PfkB_CS.
DR InterPro; IPR011611; PfkB_dom.
DR InterPro; IPR029056; Ribokinase-like.
DR PANTHER; PTHR45769; ADENOSINE KINASE; 1.
DR PANTHER; PTHR45769:SF3; ADENOSINE KINASE; 1.
DR Pfam; PF00294; PfkB; 1.
DR PRINTS; PR00989; ADENOKINASE.
DR SUPFAM; SSF53613; Ribokinase-like; 1.
DR PROSITE; PS00584; PFKB_KINASES_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:EAA28064.2};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Purine salvage {ECO:0000256|ARBA:ARBA00022726};
KW Reference proteome {ECO:0000313|Proteomes:UP000001805};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 133..447
FT /note="Carbohydrate kinase PfkB"
FT /evidence="ECO:0000259|Pfam:PF00294"
SQ SEQUENCE 454 AA; 48931 MW; 4766496E5FCEB31B CRC64;
MLLTHPITRP QRLIAGKLES LIGVSYAVGA RRHGQPSAAG ATRCFYSTAP VNPFPAANPS
TSNLVRGCDP AVGCFSLSAS NLIPVNNSFH TTTPSRFSIR SNPFSKMAAT KDYRLLCLEN
PLLDIQAFGD EALLEKYGLK ANDAILAEEK HQGLFEDLLQ NYDAKLIAGG AAQNTARGAQ
YLLPPNSVVY LGGVGDDKYA AILHDAVKQA GLRVEYRVDP KISTGRCGVV ITGHNRSMCT
ELGAANHYDL EHLKKPEVWS LVENAEVYYV GGYHFTVCPP AIMELAKQAA SGNKPFILSL
SAPFICQFFK EPLDASAPYW DYVIGNEGEA AAYAESHGLN TTDVKEIAKA LANLPKENTQ
RKRVAIITQG TEPTIVAIQG EDEVKEYPVH SIDPAKINDT NGAGDAFAGG FAAGVVEGKS
IEESIHMGQW LAKLSIQELG PSYPFPKQAY PGHN
//
