ID Q7S592_NEUCR Unreviewed; 1172 AA.
AC Q7S592;
DT 15-DEC-2003, integrated into UniProtKB/TrEMBL.
DT 15-DEC-2003, sequence version 1.
DT 27-MAR-2024, entry version 116.
DE SubName: Full=Transcriptional activator spt7 {ECO:0000313|EMBL:EAA30684.1};
GN Name=bdp-2 {ECO:0000313|EMBL:EAA30684.1};
GN ORFNames=NCU02276 {ECO:0000313|EMBL:EAA30684.1};
OS Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS FGSC 987).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX NCBI_TaxID=367110 {ECO:0000313|EMBL:EAA30684.1, ECO:0000313|Proteomes:UP000001805};
RN [1] {ECO:0000313|EMBL:EAA30684.1, ECO:0000313|Proteomes:UP000001805}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987
RC {ECO:0000313|Proteomes:UP000001805};
RX PubMed=12712197; DOI=10.1038/nature01554;
RA Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.,
RA FitzHugh W., Ma L.J., Smirnov S., Purcell S., Rehman B., Elkins T.,
RA Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.,
RA Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA Kothe G.O., Jedd G., Mewes W., Staben C., Marcotte E., Greenberg D.,
RA Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA Kamal M., Kamvysselis M., Mauceli E., Bielke C., Rudd S., Frishman D.,
RA Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA Cogoni C., Macino G., Catcheside D., Li W., Pratt R.J., Osmani S.A.,
RA DeSouza C.P., Glass L., Orbach M.J., Berglund J.A., Voelker R., Yarden O.,
RA Plamann M., Seiler S., Dunlap J., Radford A., Aramayo R., Natvig D.O.,
RA Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S.,
RA Lander E.S., Nusbaum C., Birren B.;
RT "The genome sequence of the filamentous fungus Neurospora crassa.";
RL Nature 422:859-868(2003).
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DR EMBL; CM002242; EAA30684.1; -; Genomic_DNA.
DR RefSeq; XP_959920.1; XM_954827.2.
DR AlphaFoldDB; Q7S592; -.
DR STRING; 367110.Q7S592; -.
DR PaxDb; 5141-EFNCRP00000003149; -.
DR EnsemblFungi; EAA30684; EAA30684; NCU02276.
DR GeneID; 3876042; -.
DR KEGG; ncr:NCU02276; -.
DR VEuPathDB; FungiDB:NCU02276; -.
DR HOGENOM; CLU_006198_0_0_1; -.
DR InParanoid; Q7S592; -.
DR OMA; YRRSEAK; -.
DR OrthoDB; 142354at2759; -.
DR Proteomes; UP000001805; Chromosome 7, Linkage Group VII.
DR GO; GO:0000124; C:SAGA complex; IBA:GO_Central.
DR GO; GO:0046695; C:SLIK (SAGA-like) complex; IBA:GO_Central.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0005198; F:structural molecule activity; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd05510; Bromo_SPT7_like; 1.
DR Gene3D; 1.20.920.10; Bromodomain-like; 1.
DR Gene3D; 1.10.20.10; Histone, subunit A; 1.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR018359; Bromodomain_CS.
DR InterPro; IPR006565; BTP.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR037782; Spt7.
DR PANTHER; PTHR47343; TRANSCRIPTIONAL ACTIVATOR SPT7; 1.
DR PANTHER; PTHR47343:SF1; TRANSCRIPTIONAL ACTIVATOR SPT7; 1.
DR Pfam; PF07524; Bromo_TP; 1.
DR Pfam; PF00439; Bromodomain; 1.
DR PRINTS; PR00503; BROMODOMAIN.
DR SMART; SM00297; BROMO; 1.
DR SUPFAM; SSF47370; Bromodomain; 1.
DR PROSITE; PS00633; BROMODOMAIN_1; 1.
DR PROSITE; PS50014; BROMODOMAIN_2; 1.
PE 4: Predicted;
KW Bromodomain {ECO:0000256|PROSITE-ProRule:PRU00035};
KW Reference proteome {ECO:0000313|Proteomes:UP000001805}.
FT DOMAIN 359..429
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT REGION 1..68
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 99..230
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 254..292
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 458..561
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1040..1172
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 33..52
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 101..115
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 116..130
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 131..149
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 178..196
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 209..230
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 266..292
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 542..559
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1072..1087
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1140..1154
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1172 AA; 129009 MW; 490C5C1F22ACD0A2 CRC64;
MSITNGQHAW PPPSTAAHMN GIRAVIPHPS QDDGPPRTQT PFDNSTTALM PEAPSSDPDD
DQRRSHFVDK YHKADERIAL LFADDGSYNI PVIAALKRAP TPPIPLLPPT TDHAPIQEPP
RKKAKRVIDE DDYGDDDDDD EDDDDQESDH PVATDTKPDT QLTSKHSAND AAARALLSPS
KSGSSPVHSI PSPGRQADRQ TAKEDGSQPQ TKSSEDARRE LEAARNATEE AAKRGFHTLF
YTLENDRTAM LEQQQLEESE KQLQAEMDKS GQTNHSQGAP SQNNHGSLSS ANLGASSLTL
KHLIARIDMK RDRVQASDAE LRSLMNEVRK NRSKWASEEN VGQEELYEAL DKVLTELKAH
TEYSTPFLTK VNKRDAHDYY NIIKQPMDLG TMAKRLKTLH YKSKAEFVTD LNLIWDNCLR
YNQDLANPLR RMANGMRKEA EKLIPLIPDI VIRPRAEVEA EERRKQNGGE DEAGDDSDDE
PIMSSRGRKA GTKGTNKSRK APTDQKEGTP SVDQKPILQL NGILAKSHRE GSEVDGSNGF
GTPIGGSLTP SNINGGHSGV SNADAMELDG PSLNGMALNH AFREAEEQAY EDEEYKIWKQ
VTKKDRALLA KERFQLFKDN KLNPDEPALL RTKAGMRRFL KSRKEAEAMG VITSQGDAPG
SGDGNKVAET LAQGMEDETI RNVPAYYEPQ TIIPDIPSKL QWVEDGEGQV INQHEEFLRL
VPPGQFTAPE SRLTKKFDAN IRQMQETRKL CSKISVIKQM QIQTQVYTNQ FPKYNPEPMV
EADIEPTFLA GEGPVMAPEV CRAALQRSVA KIFYHAGFEE LQPSALDTIT DIAGDYFQKI
IRSYNIYREA EWKEPPPAWK EKGVKYVPRF TNEEVILHTL SESGIELDAL QAYAKDDIDR
LGNKLTQIHD RMKAHLADLL RPALTDNSGD GSGSFEDGSE QFVGGDFAEE LGDDFFGFKA
LGLDRELGLE MLSVPLHLLQ SRVRNQYQMQ ASTTGQATTD LFEQLPPADP VTKESIQEEI
GLVKNFFLAK LHANNDQPLV EDEDLPVKQR KPRPRLAASG KITAPAKRPL REQIAAAKKR
KKEALAGANA SPEKAGAAAG GTPSKKAKTS HNLVNGTGAA GGGGGSGGNV GGLVAPSMER
MGSVNSQTNA SITDKDDAGA MGMMSPESFE QK
//
