ID Q7S8B0_NEUCR Unreviewed; 1265 AA.
AC Q7S8B0;
DT 15-DEC-2003, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 2.
DT 24-JAN-2024, entry version 88.
DE SubName: Full=Integral membrane channel protein {ECO:0000313|EMBL:EAA32573.2};
GN ORFNames=NCU08283 {ECO:0000313|EMBL:EAA32573.2};
OS Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS FGSC 987).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX NCBI_TaxID=367110 {ECO:0000313|EMBL:EAA32573.2, ECO:0000313|Proteomes:UP000001805};
RN [1] {ECO:0000313|EMBL:EAA32573.2, ECO:0000313|Proteomes:UP000001805}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987
RC {ECO:0000313|Proteomes:UP000001805};
RX PubMed=12712197; DOI=10.1038/nature01554;
RA Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.,
RA FitzHugh W., Ma L.J., Smirnov S., Purcell S., Rehman B., Elkins T.,
RA Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.,
RA Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA Kothe G.O., Jedd G., Mewes W., Staben C., Marcotte E., Greenberg D.,
RA Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA Kamal M., Kamvysselis M., Mauceli E., Bielke C., Rudd S., Frishman D.,
RA Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA Cogoni C., Macino G., Catcheside D., Li W., Pratt R.J., Osmani S.A.,
RA DeSouza C.P., Glass L., Orbach M.J., Berglund J.A., Voelker R., Yarden O.,
RA Plamann M., Seiler S., Dunlap J., Radford A., Aramayo R., Natvig D.O.,
RA Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S.,
RA Lander E.S., Nusbaum C., Birren B.;
RT "The genome sequence of the filamentous fungus Neurospora crassa.";
RL Nature 422:859-868(2003).
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DR EMBL; CM002239; EAA32573.2; -; Genomic_DNA.
DR RefSeq; XP_961809.2; XM_956716.2.
DR AlphaFoldDB; Q7S8B0; -.
DR STRING; 367110.Q7S8B0; -.
DR EnsemblFungi; EAA32573; EAA32573; NCU08283.
DR GeneID; 3877957; -.
DR KEGG; ncr:NCU08283; -.
DR VEuPathDB; FungiDB:NCU08283; -.
DR HOGENOM; CLU_003613_0_0_1; -.
DR InParanoid; Q7S8B0; -.
DR OrthoDB; 1386366at2759; -.
DR Proteomes; UP000001805; Chromosome 4, Linkage Group IV.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR InterPro; IPR005821; Ion_trans_dom.
DR PANTHER; PTHR35859:SF4; MEMBRANE CHANNEL PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11300)-RELATED; 1.
DR PANTHER; PTHR35859; NONSELECTIVE CATION CHANNEL PROTEIN; 1.
DR Pfam; PF00520; Ion_trans; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001805};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 345..362
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 374..391
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 398..419
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 439..457
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 469..494
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 506..525
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 537..564
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 587..608
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 355..562
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 1..77
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 284..312
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 758..790
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 829..849
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 862..886
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 905..947
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 980..1022
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1099..1265
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 13..27
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 284..300
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 758..774
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 776..790
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 829..846
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 862..876
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 905..929
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 980..1007
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1099..1114
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1123..1142
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1153..1167
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1168..1197
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1222..1257
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1265 AA; 141884 MW; A2FD2CCFF2B3CD9E CRC64;
MLSTLIRPFK GAARNPDDGD LLERNSEPLL RRPASVRSYT QHRHATADFT EADDDDDESD
DARQPRQNAS NRGAEDEDGL NQAIGVLPLF CAGHLDSLPI YSMTHAIRII VQARTDTTLT
WEQLRSPQVF QFLVKPMQQQ IRSQHFSRGT LYALMANCLQ FEKESQVYPA NTGTSSTRAK
VCELLAIKLL KEYSTRELVD ALSYDFYPLQ GVTGMHMPTN SNKREKPAAM RTSTLEVAIR
ASAKHFLSHP LVVQQLEAIW NGAISFYSAA DQLHRRTSIA TDLSSAQSRR QSTVRTPLLG
SQQGKEDRLR GQPLPLGRRS VTLYDPRQAS VFKLSRLRVP RYRRFLSTCS LGVLLCLFMA
VLNERSSTIT TLELIFWFWS AGFMLDEVIG FNEHGFSLYI MSFWNIFDLG ILLLLIIYYC
MRIYGVFLLD PHKLNDNAYD VLAAIAILLL PRIFSILDHY QYFSQLLIAF RLMAVDLVAV
FVLVIVVCCG FSVFFISKST DDPSVVAYSM FQILVGYSPA AWEIWPDHNW MGKTLLGLFL
IICHFVIVTL LVTVLTNSFM AIALNAKQEH QFLFAINTIS MVKNDSLFSY VAPVNILAWA
LTPLRFLMPM RQFVWLNRTV IKVTHFPLLL IIFIYERFIL APSVYEPTDL VENPGRSRHR
AVSIVDPASR TALFSPSLRI REESLVGFQK DRALEEVFRR APDFATIRTQ RRNERRKTQN
AIRTWMDQQD GTFTSPHDYG AVDNRPAQDW QRRMSMVREQ PKRFSGHDPD TRSTASDPAD
MVSNATFPTV PEYLNNGTVR RDFANEAKEN TDAENGDDEL VTNDEYEEDN ATHDTEQVRN
DMDEGQSTET GEDYFTTWVP SRFNPGLTSA QRTPVSPRPG TWRRIPMHNR TMSNNTMIFA
PAQDRPFESS SSASMDPSLS SQSRPHSTRH GIPEGSVASP SAGLRSPRRS LYLASSRPQS
MVMSPRAMVR VAPNNRSALA LENPDSASGT HDSPSSRGQS SVELPNSADL DPSALGGGLQ
AGNGVMSSST TLAAAMLEKR SQQEQDSDRM NKLMLAKTNL QASLGEVVRE MQVLKSTAPS
TAGNSADEGT SSGSYLAKKA IQQQHQQQYS TPSRRGSGEE RRSSRLSSSA GSAGSTNRDM
ANRGPRRSFR RLETATTMPT LSGQETTDRR GNSREEHEED DSDYSKSEVN NKIFEPRHNR
RSKGKGKVAI GAAIAAVAAS SNSDEREDDD RRRHQMGGGS SLDERHHRKD DFIRSGDFAL
KEGVN
//
