ID Q7S8K3_NEUCR Unreviewed; 1042 AA.
AC Q7S8K3;
DT 15-DEC-2003, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 3.
DT 24-JAN-2024, entry version 91.
DE RecName: Full=Spindle pole body component {ECO:0000256|RuleBase:RU363050};
GN ORFNames=NCU05282 {ECO:0000313|EMBL:EAA32683.3};
OS Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS FGSC 987).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX NCBI_TaxID=367110 {ECO:0000313|EMBL:EAA32683.3, ECO:0000313|Proteomes:UP000001805};
RN [1] {ECO:0000313|EMBL:EAA32683.3, ECO:0000313|Proteomes:UP000001805}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987
RC {ECO:0000313|Proteomes:UP000001805};
RX PubMed=12712197; DOI=10.1038/nature01554;
RA Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.,
RA FitzHugh W., Ma L.J., Smirnov S., Purcell S., Rehman B., Elkins T.,
RA Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.,
RA Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA Kothe G.O., Jedd G., Mewes W., Staben C., Marcotte E., Greenberg D.,
RA Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA Kamal M., Kamvysselis M., Mauceli E., Bielke C., Rudd S., Frishman D.,
RA Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA Cogoni C., Macino G., Catcheside D., Li W., Pratt R.J., Osmani S.A.,
RA DeSouza C.P., Glass L., Orbach M.J., Berglund J.A., Voelker R., Yarden O.,
RA Plamann M., Seiler S., Dunlap J., Radford A., Aramayo R., Natvig D.O.,
RA Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S.,
RA Lander E.S., Nusbaum C., Birren B.;
RT "The genome sequence of the filamentous fungus Neurospora crassa.";
RL Nature 422:859-868(2003).
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center {ECO:0000256|RuleBase:RU363050}.
CC -!- SIMILARITY: Belongs to the TUBGCP family.
CC {ECO:0000256|ARBA:ARBA00010337, ECO:0000256|RuleBase:RU363050}.
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DR EMBL; CM002239; EAA32683.3; -; Genomic_DNA.
DR RefSeq; XP_961919.3; XM_956826.3.
DR AlphaFoldDB; Q7S8K3; -.
DR STRING; 367110.Q7S8K3; -.
DR PaxDb; 5141-EFNCRP00000004996; -.
DR EnsemblFungi; EAA32683; EAA32683; NCU05282.
DR GeneID; 3878058; -.
DR KEGG; ncr:NCU05282; -.
DR VEuPathDB; FungiDB:NCU05282; -.
DR HOGENOM; CLU_006331_0_0_1; -.
DR InParanoid; Q7S8K3; -.
DR OrthoDB; 1333074at2759; -.
DR Proteomes; UP000001805; Chromosome 4, Linkage Group IV.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0000923; C:equatorial microtubule organizing center; IBA:GO_Central.
DR GO; GO:0000930; C:gamma-tubulin complex; IBA:GO_Central.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0000922; C:spindle pole; IEA:InterPro.
DR GO; GO:0005816; C:spindle pole body; IEA:UniProt.
DR GO; GO:0043015; F:gamma-tubulin binding; IBA:GO_Central.
DR GO; GO:0031122; P:cytoplasmic microtubule organization; IBA:GO_Central.
DR GO; GO:0051321; P:meiotic cell cycle; IBA:GO_Central.
DR GO; GO:0007020; P:microtubule nucleation; IBA:GO_Central.
DR GO; GO:0000278; P:mitotic cell cycle; IBA:GO_Central.
DR GO; GO:0051225; P:spindle assembly; IBA:GO_Central.
DR Gene3D; 1.20.120.1900; Gamma-tubulin complex, C-terminal domain; 1.
DR InterPro; IPR007259; GCP.
DR InterPro; IPR040457; GCP_C.
DR InterPro; IPR042241; GCP_C_sf.
DR InterPro; IPR041470; GCP_N.
DR PANTHER; PTHR19302; GAMMA TUBULIN COMPLEX PROTEIN; 1.
DR PANTHER; PTHR19302:SF70; GAMMA-TUBULIN COMPLEX COMPONENT 6; 1.
DR Pfam; PF04130; GCP_C_terminal; 1.
DR Pfam; PF17681; GCP_N_terminal; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|RuleBase:RU363050};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212,
KW ECO:0000256|RuleBase:RU363050};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701, ECO:0000256|RuleBase:RU363050};
KW Reference proteome {ECO:0000313|Proteomes:UP000001805}.
FT DOMAIN 192..594
FT /note="Gamma tubulin complex component protein N-terminal"
FT /evidence="ECO:0000259|Pfam:PF17681"
FT DOMAIN 599..1032
FT /note="Gamma tubulin complex component C-terminal"
FT /evidence="ECO:0000259|Pfam:PF04130"
FT REGION 90..112
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 846..880
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 928..964
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 97..112
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 846..875
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 947..964
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1042 AA; 116284 MW; 4D50C489D58CCC7A CRC64;
MAEERDTSAD LFAIPNFWRS SRFLDQDKAA NPLFSPNLEI SGSSFQFLPF GDQDKPLNSL
KRPLQDEGQT SFFRLPPVLR DAALSNEPQL SDDIFSDGID SAEKGKKGES QIDLDDDEEE
DYWLTLEDVE PKTPEYKSWE AFNPTAHHGP SDVVFISEAG PVAFDALITD IPDDGTEPVP
DILDNALYYA CLLGLAQGRS SVLFSWDSEK GSFVKTAPQL RISGVSVQSI QGMDQFCLDC
GNAVKALLSF SESAYFESPT PTSVALAKVV DQLVVAVQTE VAARSKAVRS ILQLQSVVKP
AHAILTYFHA LSKKLAEEKS EEGMLSCLFR EAQAAEYQGG LLPDVICEVL RLASKPWIEF
VEEWIGLKNE EGAPISKTGS GKSFVKVADK MWIDDHGFEL EEPEFFLDED RMPSFVPQDM
ARSIFDTGRN LRFLKEHHPD HSLSKRNVVA LTQPPKLEWQ FSWDAITMLE TRVNEYKAAV
TRLVQNAASG DQFSTRPSTT HEPNEYKLTY FGKSEEEVAA AVLASINQLA QPLHNNEFHD
ELTTMLHNRL YSTVDHNKEE GFNPHWSLVP LLSFGSLVDT QFKLVNDECM KLLLGPHKLR
VHTNLMRQYF LLGNGMLCSR LSHALFDPDL ESAERKAGVA FSGGVMGLRL GGRDTWPPAS
SELRLALMGV LSDCYEPPAA EKDGDGQEEE VAGMGKSMLS RTYSSDLPGN LSFAVRDLTP
EEINKCMDPD GLEALDFLRL SYKAPSGLQN IMTPVILLKY DRINKHLLRI LRMLYVVNHL
SRDVQLLARR TRLSNAAIRF CAEANHFVSK MANYFFDLGI TSIWNQFEEW LDSIEAEFLG
TGSGAQDDDN ASVGHSEQGT SRSSSSKNNK NNRKSCSPDL VRDKQSHCLD EIMSALFLRK
RQTPVLQLLE EIFTIILHFA RLMRSLNNNQ NKKPPAFNKK GKSKDEAYAN NNNNNNNNNN
NDTPESLYAM FRKKVEVFLT VCKGLGEKAA ASKNKGFGYG YGYGYGQENG MGKVGESLAE
MVPLALDMMG YYKGAGRARY QG
//
