ID Q7SHP6_NEUCR Unreviewed; 859 AA.
AC Q7SHP6;
DT 15-DEC-2003, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 3.
DT 24-JAN-2024, entry version 95.
DE SubName: Full=Ubiquitin-protein ligase Sel1/Ubx2 {ECO:0000313|EMBL:EAA36464.3};
GN ORFNames=NCU10789 {ECO:0000313|EMBL:EAA36464.3};
OS Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS FGSC 987).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX NCBI_TaxID=367110 {ECO:0000313|EMBL:EAA36464.3, ECO:0000313|Proteomes:UP000001805};
RN [1] {ECO:0000313|EMBL:EAA36464.3, ECO:0000313|Proteomes:UP000001805}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987
RC {ECO:0000313|Proteomes:UP000001805};
RX PubMed=12712197; DOI=10.1038/nature01554;
RA Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.,
RA FitzHugh W., Ma L.J., Smirnov S., Purcell S., Rehman B., Elkins T.,
RA Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.,
RA Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA Kothe G.O., Jedd G., Mewes W., Staben C., Marcotte E., Greenberg D.,
RA Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA Kamal M., Kamvysselis M., Mauceli E., Bielke C., Rudd S., Frishman D.,
RA Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA Cogoni C., Macino G., Catcheside D., Li W., Pratt R.J., Osmani S.A.,
RA DeSouza C.P., Glass L., Orbach M.J., Berglund J.A., Voelker R., Yarden O.,
RA Plamann M., Seiler S., Dunlap J., Radford A., Aramayo R., Natvig D.O.,
RA Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S.,
RA Lander E.S., Nusbaum C., Birren B.;
RT "The genome sequence of the filamentous fungus Neurospora crassa.";
RL Nature 422:859-868(2003).
CC -!- SIMILARITY: Belongs to the sel-1 family.
CC {ECO:0000256|ARBA:ARBA00038101}.
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DR EMBL; CM002236; EAA36464.3; -; Genomic_DNA.
DR RefSeq; XP_965700.3; XM_960607.3.
DR AlphaFoldDB; Q7SHP6; -.
DR STRING; 367110.Q7SHP6; -.
DR EnsemblFungi; EAA36464; EAA36464; NCU10789.
DR GeneID; 3881818; -.
DR KEGG; ncr:NCU10789; -.
DR VEuPathDB; FungiDB:NCU10789; -.
DR HOGENOM; CLU_007931_0_0_1; -.
DR InParanoid; Q7SHP6; -.
DR OrthoDB; 1378605at2759; -.
DR Proteomes; UP000001805; Chromosome 1, Linkage Group I.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0036503; P:ERAD pathway; IBA:GO_Central.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 4.
DR InterPro; IPR006597; Sel1-like.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR11102:SF147; FIBRONECTIN TYPE-II DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR11102; SEL-1-LIKE PROTEIN; 1.
DR Pfam; PF08238; Sel1; 10.
DR SMART; SM00671; SEL1; 10.
DR SUPFAM; SSF81901; HCP-like; 3.
PE 3: Inferred from homology;
KW Ligase {ECO:0000313|EMBL:EAA36464.3}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001805};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..37
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 38..859
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004292947"
FT TRANSMEM 771..790
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 45..66
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 800..859
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 45..59
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 859 AA; 95243 MW; 9C2F4EE07C8AB6E8 CRC64;
MTLSSGFAST TFPKSTTMRR FLLYIILLLQ VAVFSHADVP NNQQHVLSGD ESNGATGNTL
PPELPAAQHV QPGAALVNAA LVELRKLHQP LHYKIRKNPG ILRTVLHLAS KALPAIRLTA
PSPASSHDAV SGPLLHATRL LEESAQKNNS DALYILGDMN FYGNFSHPRN LKTAFGYYQK
LALLNGNSSA MYMMGVMYST GVGGAVEPDQ ARALLYYTFA ANQGHTRAEM AVAHRHYAGI
GTTKNCETAV KYYKRVADKA IAWYRSGPPG GMSWISESHR IADELGGTYG VGASVSSSGQ
NAPHKNPTSD AQASIEDILE YLDLMSQKGD VKATFNLGRI FYDGQRNLPR DYAKAREYFL
KVASKTWNKK GQVFENKTPS FHTISCRAAG YIGRMYLRGE GVEQSFRLAE FWFRRGNEQA
DQQSRHGLGL MYLNGYGVEQ NLDLALKFFN AAAETAYPPS HVQLAALYLD QGQSDEDIYA
ANHHLDLAAK YYNMEAYYYI GEMTYFGLGR ERQCEVALNY YKAVAEKVEP FVSSWAEANL
AYEAGEIELA FLEYLHAAEQ GYETAQNNVA YILDPQKSYL TIPQWLCPKA QKLTLLQNPT
LALIYWTRSS RQGNIDATVK MGDYYLGGIG TDADVDKAVQ CYTAASEHYQ SAQALWNLGW
MHENGIGLTQ DYHLAKRYYD TALETNDEAY LPVSLSLLKL RARSAWNTFT NGRINSIQDE
PTEKKEWSLS EWINNFLQDE MGYYGDDMYD GYEDAMPGAD SDLGAFEEGD ILETLVIMGL
AAALVFLVLY RQQRQQAARR QQEDEARRQP QEQQGQGVGR AAGGAFANGQ QQQQAGNGGF
FPQPGAPGFG QWAVGGVGH
//
