ID Q7SID4_THETH Unreviewed; 274 AA.
AC Q7SID4;
DT 15-DEC-2003, integrated into UniProtKB/TrEMBL.
DT 15-DEC-2003, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Transferase {ECO:0000313|PDB:1IPA};
OS Thermus thermophilus.
OC Bacteria; Deinococcota; Deinococci; Thermales; Thermaceae; Thermus.
OX NCBI_TaxID=274 {ECO:0000313|PDB:1IPA};
RN [1] {ECO:0000313|PDB:1IPA, ECO:0007829|PDB:1IPA}
RP X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS).
RX PubMed=12077432; DOI=10.1107/S0907444902006601;
RA Nureki O., Shirouzu M., Hashimoto K., Ishitani R., Terada T., Tamakoshi M.,
RA Oshima T., Chijimatsu M., Takio K., Vassylyev D.G., Shibata T., Inoue Y.,
RA Kuramitsu S., Yokoyama S.;
RT "An enzyme with a deep trefoil knot for the active-site architecture.";
RL Acta Crystallogr. D 58:1129-1137(2002).
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DR PDB; 1IPA; X-ray; 2.40 A; A=1-274.
DR PDBsum; 1IPA; -.
DR AlphaFoldDB; Q7SID4; -.
DR SMR; Q7SID4; -.
DR EvolutionaryTrace; Q7SID4; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0008173; F:RNA methyltransferase activity; IEA:InterPro.
DR GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR CDD; cd18104; SpoU-like_RNA-MTase; 1.
DR Gene3D; 3.30.1330.30; -; 1.
DR Gene3D; 3.40.1280.10; -; 1.
DR InterPro; IPR029028; Alpha/beta_knot_MTases.
DR InterPro; IPR029064; Ribosomal_eL30-like_sf.
DR InterPro; IPR001537; SpoU_MeTrfase.
DR InterPro; IPR013123; SpoU_subst-bd.
DR InterPro; IPR029026; tRNA_m1G_MTases_N.
DR PANTHER; PTHR43191:SF16; RNA METHYLASE-RELATED; 1.
DR PANTHER; PTHR43191; RRNA METHYLTRANSFERASE 3; 1.
DR Pfam; PF00588; SpoU_methylase; 1.
DR Pfam; PF08032; SpoU_sub_bind; 1.
DR SMART; SM00967; SpoU_sub_bind; 1.
DR SUPFAM; SSF75217; alpha/beta knot; 1.
DR SUPFAM; SSF55315; L30e-like; 1.
PE 1: Evidence at protein level;
KW 3D-structure {ECO:0000313|PDB:1IPA, ECO:0007829|PDB:1IPA}.
FT DOMAIN 30..106
FT /note="RNA 2-O ribose methyltransferase substrate binding"
FT /evidence="ECO:0000259|SMART:SM00967"
SQ SEQUENCE 274 AA; 29980 MW; CD2DF79B004CBF7E CRC64;
MRITSTANPR IKELARLLER KHRDSQRRFL IEGAREIERA LQAGIELEQA LVWEGGLNPE
EQQVYAALGR VGRLALLEVS EAVLKKLSVR DNPAGLIALA RMPERTLEEY RPSPDALILV
AVGLEKPGNL GAVLRSADAA GAEAVLVAGG VDLYSPQVIR NSTGVVFSLR TLAASESEVL
DWIKQHNLPL VATTPHAEAL YWEANLRPPV AIAVGPEHEG LRAAWLEAAQ TQVRIPMQGQ
ADSLNVSVSA ALLLYEALRQ RLLRDRLTKT HSTL
//
