ID Q7T264_XENLA Unreviewed; 364 AA.
AC Q7T264;
DT 01-OCT-2003, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2003, sequence version 1.
DT 24-JAN-2024, entry version 76.
DE SubName: Full=T cell-specific transcription factor 1, isoform C {ECO:0000313|EMBL:AAO23663.1};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|EMBL:AAO23663.1};
RN [1] {ECO:0000313|EMBL:AAO23663.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12711535; DOI=10.1016/S1567-133X(03)00039-5;
RA Roel G., van den Broek O., Spieker N., Peterson-Maduro J., Destree O.;
RT "Tcf-1 expression during Xenopus development.";
RL Gene Expr. Patterns 3:123-126(2003).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the TCF/LEF family.
CC {ECO:0000256|ARBA:ARBA00006569}.
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DR EMBL; AY163239; AAO23663.1; -; mRNA.
DR AlphaFoldDB; Q7T264; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd21996; HMG-box_TCF7-like; 1.
DR Gene3D; 1.10.30.10; High mobility group box domain; 1.
DR Gene3D; 4.10.900.10; TCF3-CBD (Catenin binding domain); 1.
DR InterPro; IPR027397; Catenin-bd_sf.
DR InterPro; IPR013558; CTNNB1-bd_N.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR024940; TCF/LEF.
DR PANTHER; PTHR10373:SF33; TRANSCRIPTION FACTOR 7; 1.
DR PANTHER; PTHR10373; TRANSCRIPTION FACTOR 7 FAMILY MEMBER; 1.
DR Pfam; PF08347; CTNNB1_binding; 1.
DR Pfam; PF00505; HMG_box; 1.
DR SMART; SM01366; c-clamp; 1.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF47095; HMG-box; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
PE 2: Evidence at transcript level;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00267}; Nucleus {ECO:0000256|PROSITE-ProRule:PRU00267};
KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687}.
FT DOMAIN 250..318
FT /note="HMG box"
FT /evidence="ECO:0000259|PROSITE:PS50118"
FT DNA_BIND 250..318
FT /note="HMG box"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00267"
FT REGION 1..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 320..349
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 15..36
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 364 AA; 41103 MW; A3F441C4B1F4A290 CRC64;
MPQMNSAGED DLGASDEMIS FKDEGDQEEK IRENGFTERD LADLKSSLVN ESEVASHPRV
PETHPEAIRR AQDVQLVYQD KFSAHMEDGI KHQDEGMYKG SGYPGYPFLM LSDPYLSNGS
VSALSNKVPV VQPSHGVHPL IPYNSESFSH GSHSPHLPVD LNQKQGVHRP SQTPDVPTFY
PLPSGGVGQI SPSMGWFPHP LMLSPSMHTT GIPHPAIIPH SGNKDMDIYE RNMKQHSEPK
REKEPKKPAI KKPLNAFMLY MKEMRANVIA ECTLKESAAI NQILGGRWHA LSREEQSKYY
ELARKERQLH MQLYPGWSAR DNYGKRKRRT REKHQDSSSD PGSPKKCRAR FGLNQQTDWC
GPCR
//
