ID ABTB2_MOUSE Reviewed; 1024 AA.
AC Q7TQI7;
DT 01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 27-MAR-2024, entry version 139.
DE RecName: Full=Ankyrin repeat and BTB/POZ domain-containing protein 2;
GN Name=Abtb2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Heart, Liver, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: May be involved in the initiation of hepatocyte growth.
CC {ECO:0000250}.
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DR EMBL; BC054399; AAH54399.1; -; mRNA.
DR CCDS; CCDS16479.1; -.
DR RefSeq; NP_849221.2; NM_178890.3.
DR AlphaFoldDB; Q7TQI7; -.
DR SMR; Q7TQI7; -.
DR BioGRID; 221238; 2.
DR STRING; 10090.ENSMUSP00000075566; -.
DR iPTMnet; Q7TQI7; -.
DR PhosphoSitePlus; Q7TQI7; -.
DR EPD; Q7TQI7; -.
DR MaxQB; Q7TQI7; -.
DR PaxDb; 10090-ENSMUSP00000075566; -.
DR ProteomicsDB; 285969; -.
DR Pumba; Q7TQI7; -.
DR Antibodypedia; 12992; 70 antibodies from 17 providers.
DR Ensembl; ENSMUST00000076212.4; ENSMUSP00000075566.4; ENSMUSG00000032724.6.
DR GeneID; 99382; -.
DR KEGG; mmu:99382; -.
DR UCSC; uc008lix.1; mouse.
DR AGR; MGI:2139365; -.
DR CTD; 25841; -.
DR MGI; MGI:2139365; Abtb2.
DR VEuPathDB; HostDB:ENSMUSG00000032724; -.
DR eggNOG; ENOG502QSQY; Eukaryota.
DR GeneTree; ENSGT00940000157661; -.
DR HOGENOM; CLU_001918_0_0_1; -.
DR InParanoid; Q7TQI7; -.
DR OMA; LQCNGST; -.
DR OrthoDB; 1085234at2759; -.
DR PhylomeDB; Q7TQI7; -.
DR TreeFam; TF106437; -.
DR BioGRID-ORCS; 99382; 1 hit in 78 CRISPR screens.
DR ChiTaRS; Abtb2; mouse.
DR PRO; PR:Q7TQI7; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q7TQI7; Protein.
DR Bgee; ENSMUSG00000032724; Expressed in stria vascularis of cochlear duct and 260 other cell types or tissues.
DR ExpressionAtlas; Q7TQI7; baseline and differential.
DR Genevisible; Q7TQI7; MM.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0097237; P:cellular response to toxic substance; IMP:MGI.
DR CDD; cd18526; BACK_ABTB2; 1.
DR CDD; cd18350; BTB_POZ_ABTB2_BPOZ2; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 1.10.20.10; Histone, subunit A; 1.
DR InterPro; IPR048063; ABTB2_BTB_POZ.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR PANTHER; PTHR46071; ANKYRIN REPEAT AND BTB/POZ DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR46071:SF3; ANKYRIN REPEAT AND BTB_POZ DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF00651; BTB; 1.
DR SMART; SM00248; ANK; 5.
DR SMART; SM00225; BTB; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF47113; Histone-fold; 2.
DR SUPFAM; SSF54695; POZ domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 3.
DR PROSITE; PS50097; BTB; 1.
PE 1: Evidence at protein level;
KW ANK repeat; Reference proteome; Repeat.
FT CHAIN 1..1024
FT /note="Ankyrin repeat and BTB/POZ domain-containing protein
FT 2"
FT /id="PRO_0000066888"
FT REPEAT 521..550
FT /note="ANK 1"
FT REPEAT 567..596
FT /note="ANK 2"
FT REPEAT 606..635
FT /note="ANK 3"
FT REPEAT 649..678
FT /note="ANK 4"
FT DOMAIN 844..913
FT /note="BTB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
SQ SEQUENCE 1024 AA; 113503 MW; 39509A02F0DE093A CRC64;
MAGTYSSTLK TLEDLTLDSG YGAGDSCRSL SLSSSKSNSQ ALNSSAQQHR GAAWWCYSGS
MNSRHNSWDT VNTVLPEDPE VADLFSRCPR LPELEEFPWT EGDVARVLRK SVGGRRLPSF
SAEAVRRLAG LLRRALIRVA REAQRLSVLH AKCTRFEVQS AVRLVHSWAL AESCALAAVK
ALSLYSMSAG DGLRRGKSAR CGLTFSVGRF FRWMVDTRIS VRIHEYAAIS LTACMENLVE
EIRARVLASQ SPDGGGAGGG EVSAEALEMV INNDAELWGV LQPYEHLICG KNANGVLSLP
AYFSPYNGGS LGHDERADAY AQLELRTLEQ SLLATCVGSI SELSDLVSRA MHHMQGRHPL
CPGTSPARQA RQPPQPITWS PDALHTLYYF LRCPQMESME NPNLDPPRMT LNNERPFMLL
PPLMEWMRVA ITYAEHRRSP TVDSGDIRQA ARLLLPGLDC EPRQLKPECC FSSFRRLDAR
AATERFNQDL GFRMLNCGRT DLISQAIEAL GPDGVNTMDD QGMTPLMYAC AAGDEAMVQM
LIDAGANLDI QVPSHSPRHP SVHPDSRHWT SLTFAVLHGH ISVVQLLLDA GAHVEGSAVN
SGEDSYAETP LQLASAAGNY ELVSLLLSRG ADPLLSMLEA NGMASSLHEE MNCFSHSAAH
GHRNVLRKLL TQPQQAKADV LSLEEILAEG VEESDTSSQG SSEGPVRLSR TRTKALQEAM
YYSAEHGYLD ITMELRALGV PWKLHIWIES LRTSFSQSRY SVVQSLLKDF SSIKEEEYNE
ELVTEGLQLM FDILKTSKND SVLQQLATIF THCYGTSPIP SIPEIRKTLP ARLDPHFLNN
KEMSDVTFLV EGKLFYAHKV LLVTASNRFK TLMTNKSEQD GDSSKTIEIS DIKYHIFQML
MQYLYYGGTE SMEIPTADIL QLLSAANLFQ LDALQRHCEI LCSQTLSVES AVNTYKYAKI
HNAPELALFC EGFFLKHMKA LLEQDAFRQL IYGRSSKVQG LDPLQDLQST LAERVHSVYV
TSRV
//
