ID Q7V0N8_PROMP Unreviewed; 500 AA.
AC Q7V0N8;
DT 01-OCT-2003, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2003, sequence version 1.
DT 27-MAR-2024, entry version 108.
DE SubName: Full=Putative ADP-heptose synthase {ECO:0000313|EMBL:CAE19677.1};
DE EC=2.7.-.- {ECO:0000313|EMBL:CAE19677.1};
GN Name=rfaE {ECO:0000313|EMBL:CAE19677.1};
GN OrderedLocusNames=PMM1218 {ECO:0000313|EMBL:CAE19677.1};
OS Prochlorococcus marinus subsp. pastoris (strain CCMP1986 / NIES-2087 /
OS MED4).
OC Bacteria; Cyanobacteriota; Cyanophyceae; Synechococcales;
OC Prochlorococcaceae; Prochlorococcus.
OX NCBI_TaxID=59919 {ECO:0000313|EMBL:CAE19677.1, ECO:0000313|Proteomes:UP000001026};
RN [1] {ECO:0000313|EMBL:CAE19677.1, ECO:0000313|Proteomes:UP000001026}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCMP1986 / NIES-2087 / MED4
RC {ECO:0000313|Proteomes:UP000001026};
RX PubMed=12917642; DOI=10.1038/nature01947;
RA Rocap G., Larimer F.W., Lamerdin J.E., Malfatti S., Chain P., Ahlgren N.A.,
RA Arellano A., Coleman M., Hauser L., Hess W.R., Johnson Z.I., Land M.L.,
RA Lindell D., Post A.F., Regala W., Shah M., Shaw S.L., Steglich C.,
RA Sullivan M.B., Ting C.S., Tolonen A., Webb E.A., Zinser E.R.,
RA Chisholm S.W.;
RT "Genome divergence in two Prochlorococcus ecotypes reflects oceanic niche
RT differentiation.";
RL Nature 424:1042-1047(2003).
CC -!- FUNCTION: Catalyzes the ADP transfer from ATP to D-glycero-beta-D-
CC manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose.
CC {ECO:0000256|ARBA:ARBA00003753}.
CC -!- FUNCTION: Catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-
CC phosphate at the C-1 position to selectively form D-glycero-beta-D-
CC manno-heptose-1,7-bisphosphate. {ECO:0000256|ARBA:ARBA00002319}.
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DR EMBL; BX548174; CAE19677.1; -; Genomic_DNA.
DR RefSeq; WP_011132852.1; NC_005072.1.
DR AlphaFoldDB; Q7V0N8; -.
DR STRING; 59919.PMM1218; -.
DR KEGG; pmm:PMM1218; -.
DR eggNOG; COG0615; Bacteria.
DR eggNOG; COG2870; Bacteria.
DR HOGENOM; CLU_534032_0_0_3; -.
DR OrthoDB; 9802794at2; -.
DR Proteomes; UP000001026; Chromosome.
DR GO; GO:0016779; F:nucleotidyltransferase activity; IEA:InterPro.
DR GO; GO:0016773; F:phosphotransferase activity, alcohol group as acceptor; IEA:InterPro.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-KW.
DR CDD; cd01172; RfaE_like; 1.
DR Gene3D; 3.40.1190.20; -; 1.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR InterPro; IPR004821; Cyt_trans-like.
DR InterPro; IPR011611; PfkB_dom.
DR InterPro; IPR011913; RfaE_dom_I.
DR InterPro; IPR029056; Ribokinase-like.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR NCBIfam; TIGR00125; cyt_tran_rel; 1.
DR PANTHER; PTHR46969; BIFUNCTIONAL PROTEIN HLDE; 1.
DR PANTHER; PTHR46969:SF1; BIFUNCTIONAL PROTEIN HLDE; 1.
DR Pfam; PF01467; CTP_transf_like; 1.
DR Pfam; PF00294; PfkB; 1.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
DR SUPFAM; SSF53613; Ribokinase-like; 1.
PE 4: Predicted;
KW Carbohydrate metabolism {ECO:0000256|ARBA:ARBA00023277};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Transferase {ECO:0000313|EMBL:CAE19677.1}.
FT DOMAIN 24..125
FT /note="Cytidyltransferase-like"
FT /evidence="ECO:0000259|Pfam:PF01467"
FT DOMAIN 183..483
FT /note="Carbohydrate kinase PfkB"
FT /evidence="ECO:0000259|Pfam:PF00294"
SQ SEQUENCE 500 AA; 55472 MW; EF02E8F52851D52D CRC64;
MSSFITPIIQ INEACKYNNC ILGYGHFNSI HTGHIRYLKR AKDINNILLV AVLKDPQFQG
VIFTQEERAE SIAQLGIANA IVLLPDNNLE KAVNIINPRE LILGKEYENS NINNINTTVK
NLKAKNKAIY FHAGEINYAN TELLTISEDN LKKEREKEFL KALKRQNISC ENLIETSKRI
KNTKLIVIGD SIVDQYASCE ALGMSAEAPV IVVKELEQKN FVGGAAIVAS HITRLGSECE
FISVIGSDEP GKWIHKELKK NSVKPNLFID KNRPTTFKKR YIVENQKLFR VSRLEDHMID
KETTKKILDY VYKASLNANG IVISDFVYGI ITGELLKGIT KFANESGIKL YGDLQCSSQI
GDISRMEDFT LICPNEREAR ISIQNKDIGL EELCRILISK TKCENLIMKL GANGFIVYSH
QKGESPRVQA FPALSVNPVD VSGAGDTLLS IMAAGLSSGS KIMDVAALAC CGSAIAVDTM
GNNPIEIEKI IDKAIKIFNK
//
