ID Q7V462_PROMM Unreviewed; 280 AA.
AC Q7V462;
DT 01-OCT-2003, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2003, sequence version 1.
DT 27-MAR-2024, entry version 107.
DE SubName: Full=Putative 3-hydroxyisobutyrate dehydrogenase {ECO:0000313|EMBL:CAE22279.1};
DE EC=1.1.1.31 {ECO:0000313|EMBL:CAE22279.1};
GN OrderedLocusNames=PMT_2105 {ECO:0000313|EMBL:CAE22279.1};
OS Prochlorococcus marinus (strain MIT 9313).
OC Bacteria; Cyanobacteriota; Cyanophyceae; Synechococcales;
OC Prochlorococcaceae; Prochlorococcus.
OX NCBI_TaxID=74547 {ECO:0000313|EMBL:CAE22279.1, ECO:0000313|Proteomes:UP000001423};
RN [1] {ECO:0000313|EMBL:CAE22279.1, ECO:0000313|Proteomes:UP000001423}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MIT 9313 {ECO:0000313|Proteomes:UP000001423};
RX PubMed=12917642; DOI=10.1038/nature01947;
RA Rocap G., Larimer F.W., Lamerdin J.E., Malfatti S., Chain P., Ahlgren N.A.,
RA Arellano A., Coleman M., Hauser L., Hess W.R., Johnson Z.I., Land M.L.,
RA Lindell D., Post A.F., Regala W., Shah M., Shaw S.L., Steglich C.,
RA Sullivan M.B., Ting C.S., Tolonen A., Webb E.A., Zinser E.R.,
RA Chisholm S.W.;
RT "Genome divergence in two Prochlorococcus ecotypes reflects oceanic niche
RT differentiation.";
RL Nature 424:1042-1047(2003).
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DR EMBL; BX548175; CAE22279.1; -; Genomic_DNA.
DR AlphaFoldDB; Q7V462; -.
DR KEGG; pmt:PMT_2105; -.
DR eggNOG; COG2084; Bacteria.
DR HOGENOM; CLU_035117_1_0_3; -.
DR Proteomes; UP000001423; Chromosome.
DR GO; GO:0008442; F:3-hydroxyisobutyrate dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0016054; P:organic acid catabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR006115; 6PGDH_NADP-bd.
DR InterPro; IPR029154; HIBADH-like_NADP-bd.
DR InterPro; IPR015815; HIBADH-related.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43060; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR PANTHER; PTHR43060:SF15; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF14833; NAD_binding_11; 1.
DR Pfam; PF03446; NAD_binding_2; 1.
DR PIRSF; PIRSF000103; HIBADH; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000313|EMBL:CAE22279.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001423}.
FT DOMAIN 1..147
FT /note="6-phosphogluconate dehydrogenase NADP-binding"
FT /evidence="ECO:0000259|Pfam:PF03446"
FT DOMAIN 150..266
FT /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF14833"
FT ACT_SITE 156
FT /evidence="ECO:0000256|PIRSR:PIRSR000103-1"
SQ SEQUENCE 280 AA; 29481 MW; 9521B83F81B5146B CRC64;
MAANLLAAGY ELKVHSRSRA AEQNLALQGS RSCSSPAEAA ADSQALLICV SDDEAVEEVL
FGSQGAASML SSGAVVVDFS TITPATSISM AERLADQGVT YLDAPVTGGT EGARAGTLTV
LVGGNKQALA RVQPLLEVIG ERIHHFGSVG RGQQVKALNQ VLVAGSYAAL AEAIALGQQL
GLPMQEVITA LQHGAAGSWA LKHRSTAMLE DHYPLGFKLA LHHKDLGIAL ETAERAGLQL
PITSQVKSME ANLIEHGHSE EDVSVLRRWF DQQQAESQPF
//
