ID Q7YWU1_CAEEL Unreviewed; 275 AA.
AC Q7YWU1;
DT 01-OCT-2003, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2006, sequence version 2.
DT 27-MAR-2024, entry version 126.
DE RecName: Full=RING-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012483};
DE EC=2.3.2.27 {ECO:0000256|ARBA:ARBA00012483};
GN ORFNames=CELE_T02C1.2 {ECO:0000313|EMBL:CAE17940.2}, T02C1.2
GN {ECO:0000313|EMBL:CAE17940.2, ECO:0000313|WormBase:T02C1.2};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CAE17940.2, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CAE17940.2, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CAE17940.2,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.27; Evidence={ECO:0000256|ARBA:ARBA00000900};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BX284603; CAE17940.2; -; Genomic_DNA.
DR RefSeq; NP_001022740.2; NM_001027569.3.
DR AlphaFoldDB; Q7YWU1; -.
DR SMR; Q7YWU1; -.
DR STRING; 6239.T02C1.2.1; -.
DR PaxDb; 6239-T02C1-2; -.
DR EnsemblMetazoa; T02C1.2.1; T02C1.2.1; WBGene00011366.
DR GeneID; 176306; -.
DR KEGG; cel:CELE_T02C1.2; -.
DR UCSC; T02C1.2; c. elegans.
DR AGR; WB:WBGene00011366; -.
DR WormBase; T02C1.2; CE39760; WBGene00011366; -.
DR eggNOG; KOG4159; Eukaryota.
DR GeneTree; ENSGT00940000153680; -.
DR HOGENOM; CLU_075151_0_0_1; -.
DR InParanoid; Q7YWU1; -.
DR OMA; CQQWVYW; -.
DR OrthoDB; 209481at2759; -.
DR Reactome; R-CEL-3108214; SUMOylation of DNA damage response and repair proteins.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00011366; Expressed in embryo and 4 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0035861; C:site of double-strand break; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0031491; F:nucleosome binding; IBA:GO_Central.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IBA:GO_Central.
DR GO; GO:0006302; P:double-strand break repair; IBA:GO_Central.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR23328:SF0; RING-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR23328; UNCHARACTERIZED; 1.
DR Pfam; PF13923; zf-C3HC4_2; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 52..74
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 100..138
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
SQ SEQUENCE 275 AA; 32897 MW; 0321703C381CA078 CRC64;
MPWCHPRFAP IVYILFFYAL YMLLVLPITE LLEFVLRAFL GIESRSHSQW SRWIYGFCLL
TFLPCYATVF FISWRKHRAK PLFTPKWKNS NDLDEDDVLC TICYDIIVEP HTLRCQHSFC
KKCIDQCLPL TRKCPSCQQW VYWSRKNKIF KEKVLRWVKE KQREDEYEEV MQLKKEMKPV
KVGCMARFWP FIIPFFEVPE REHHRNRQIR LRPIRRAAIQ PAPIHLNESL VVEVIDEIEN
VPVNTQISPV MPPDEESNPV EIITCDQNQQ PVDVV
//