ID Q7Z205_CAEEL Unreviewed; 626 AA.
AC Q7Z205;
DT 01-OCT-2003, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2005, sequence version 2.
DT 27-MAR-2024, entry version 138.
DE SubName: Full=Cyclic nucleotide-binding domain-containing protein {ECO:0000313|EMBL:CAD91630.2};
GN Name=cng-3 {ECO:0000313|EMBL:CAD91630.2,
GN ECO:0000313|WormBase:F38E11.12};
GN ORFNames=CELE_F38E11.12 {ECO:0000313|EMBL:CAD91630.2}, F38E11.12
GN {ECO:0000313|WormBase:F38E11.12};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CAD91630.2, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CAD91630.2, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CAD91630.2,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BX284604; CAD91630.2; -; Genomic_DNA.
DR RefSeq; NP_001023194.1; NM_001028023.1.
DR AlphaFoldDB; Q7Z205; -.
DR SMR; Q7Z205; -.
DR STRING; 6239.F38E11.12.1; -.
DR TCDB; 1.A.1.5.34; the voltage-gated ion channel (vic) superfamily.
DR PaxDb; 6239-F38E11-12; -.
DR EnsemblMetazoa; F38E11.12.1; F38E11.12.1; WBGene00000563.
DR GeneID; 3565463; -.
DR KEGG; cel:CELE_F38E11.12; -.
DR UCSC; F38E11.12; c. elegans.
DR AGR; WB:WBGene00000563; -.
DR WormBase; F38E11.12; CE37910; WBGene00000563; cng-3.
DR eggNOG; KOG0500; Eukaryota.
DR HOGENOM; CLU_005746_12_0_1; -.
DR InParanoid; Q7Z205; -.
DR OMA; EYLPWPY; -.
DR OrthoDB; 76907at2759; -.
DR PhylomeDB; Q7Z205; -.
DR Reactome; R-CEL-2485179; Activation of the phototransduction cascade.
DR Reactome; R-CEL-2514859; Inactivation, recovery and regulation of the phototransduction cascade.
DR Reactome; R-CEL-5620916; VxPx cargo-targeting to cilium.
DR Proteomes; UP000001940; Chromosome IV.
DR Bgee; WBGene00000563; Expressed in larva.
DR GO; GO:0017071; C:intracellular cyclic nucleotide activated cation channel complex; IBA:GO_Central.
DR GO; GO:0097730; C:non-motile cilium; IDA:WormBase.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0030553; F:cGMP binding; IBA:GO_Central.
DR GO; GO:0005222; F:intracellular cAMP-activated cation channel activity; IBA:GO_Central.
DR GO; GO:0005223; F:intracellular cGMP-activated cation channel activity; IBA:GO_Central.
DR GO; GO:0044877; F:protein-containing complex binding; IBA:GO_Central.
DR GO; GO:0098655; P:monoatomic cation transmembrane transport; IBA:GO_Central.
DR GO; GO:0048609; P:multicellular organismal reproductive process; IGI:WormBase.
DR GO; GO:0040010; P:positive regulation of growth rate; IGI:WormBase.
DR GO; GO:0009408; P:response to heat; IMP:WormBase.
DR CDD; cd00038; CAP_ED; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.10.287.630; Helix hairpin bin; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR InterPro; IPR018488; cNMP-bd_CS.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR PANTHER; PTHR45638:SF14; CYCLIC NUCLEOTIDE-BINDING DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45638; CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR SMART; SM00100; cNMP; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
DR PROSITE; PS00888; CNMP_BINDING_1; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
PE 4: Predicted;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 60..85
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 97..120
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 140..157
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 197..215
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 330..352
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 430..550
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
SQ SEQUENCE 626 AA; 73595 MW; F0D4AA28BA726B10 CRC64;
MSTHSAQKLP NLHERKRRMS KKPDDDDLIP QHFEYENQYE KWRAANPRIE YDFSVDESGY
IYWIWTFFVV CGCLYNIIVL SVLAFENIRY AYIEKILPIN IAFDTVFLFD IILRSMLSFY
EDGVLITSFS ETWRHYVHSF YFAIDLLAIF PFDYLLIRKT SAAFCRLNRF LKIYRIANFI
AQSYGKLTQV TISLSKIFTA CFLLFHVNAC VFYIISVNSD TSSWDGVNAT FDDDEYLPWP
YTPEKITDAY FVGCDGRTDC YNPYFYYDEA REDHLVELYH FWRTDNRTHI YNFSQFTKEY
TLSMYWSAMT MTTLGEQPAP NTSLQNAFEI VNTLAGLLLF AVIMGSIGDL VANANAVKTF
WQTLMDGLKQ YMTYRNLNER LQTKVLKYCE YEMAEETIMK EHEVRDELPA KLYGHVTTSI
IGASLVRSPL FRASERSFLN DISQLLEPHY FCPGDVVIEK GQLCSSMFII VCGQMVEITE
DNEIDHFEGE ILGDVNLIWF NNHLNHNRHQ HNVISSAFSQ IHMLSRDDFF KVLSSYDPKL
KRRLCDVAFY LQRQRGELDD KKRCLSENED IESNLKRLAI DTLELHDKMT EMEEEFWDFS
ATAKRKLFES EMVVCDLLNN SQRRSR
//
