ID Q7ZUZ7_DANRE Unreviewed; 181 AA.
AC Q7ZUZ7; A0A2R8Q8I7; F6NGW6;
DT 01-JUN-2003, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2003, sequence version 1.
DT 27-MAR-2024, entry version 162.
DE RecName: Full=ADP-ribosylation factor {ECO:0000256|RuleBase:RU369003};
GN Name=arf2b {ECO:0000313|Ensembl:ENSDARP00000004127,
GN ECO:0000313|RefSeq:NP_958888.1,
GN ECO:0000313|ZFIN:ZDB-GENE-030131-5234};
GN Synonyms=arf1l {ECO:0000313|EMBL:AAH46063.1,
GN ECO:0000313|RefSeq:NP_958888.1}, fa19d09
GN {ECO:0000313|RefSeq:NP_958888.1}, wu:fb19d05
GN {ECO:0000313|RefSeq:NP_958888.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAH62853.1};
RN [1] {ECO:0000313|EMBL:AAH62853.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Whole {ECO:0000313|EMBL:AAH62853.1}, and Whole body
RC {ECO:0000313|EMBL:AAH46063.1};
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AAS92646.1}
RP NUCLEOTIDE SEQUENCE.
RA Zhang G.W., Sun X.J., Wu X.Y., Song H.D., Liu T.X., Zhou Y., Sheng Y.,
RA Chen Y., Ruan Z., Jiang C.L., Fan H.Y., Zon L.I., Kanki J.P., Look A.T.,
RA Chen Z.;
RT "Gene Expression Profiling in the Zebrafish Kidney Marrow Tissue.";
RL Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|RefSeq:NP_958888.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=16132083;
RA Mathavan S., Lee S.G., Mak A., Miller L.D., Murthy K.R., Govindarajan K.R.,
RA Tong Y., Wu Y.L., Lam S.H., Yang H., Ruan Y., Korzh V., Gong Z., Liu E.T.,
RA Lufkin T.;
RT "Transcriptome analysis of zebrafish embryogenesis using microarrays.";
RL PLoS Genet. 1:260-276(2005).
RN [4] {ECO:0000313|RefSeq:NP_958888.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=20816853;
RA Liu H.Y., Lee N., Tsai T.Y., Ho S.Y.;
RT "Zebrafish fat-free, a novel Arf effector, regulates phospholipase D to
RT mediate lipid and glucose metabolism.";
RL Biochim. Biophys. Acta 1801:1330-1340(2010).
RN [5] {ECO:0000313|RefSeq:NP_958888.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=20392139;
RA Abramsson A., Westman-Brinkmalm A., Pannee J., Gustavsson M., von Otter M.,
RA Blennow K., Brinkmalm G., Kettunen P., Zetterberg H.;
RT "Proteomics profiling of single organs from individual adult zebrafish.";
RL Zebrafish 7:161-168(2010).
RN [6] {ECO:0000313|Ensembl:ENSDARP00000004127}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000004127};
RG Ensembl;
RL Submitted (FEB-2012) to UniProtKB.
RN [7] {ECO:0000313|Ensembl:ENSDARP00000004127, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000004127};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [8] {ECO:0000313|RefSeq:NP_958888.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26469318;
RA Elkon R., Milon B., Morrison L., Shah M., Vijayakumar S., Racherla M.,
RA Leitch C.C., Silipino L., Hadi S., Weiss-Gayet M., Barras E., Schmid C.D.,
RA Ait-Lounis A., Barnes A., Song Y., Eisenman D.J., Eliyahu E.,
RA Frolenkov G.I., Strome S.E., Durand B., Zaghloul N.A., Jones S.M.,
RA Reith W., Hertzano R.;
RT "RFX transcription factors are essential for hearing in mice.";
RL Nat. Commun. 6:8549-8549(2015).
RN [9] {ECO:0000313|RefSeq:NP_958888.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=28252024;
RA Bayes A., Collins M.O., Reig-Viader R., Gou G., Goulding D., Izquierdo A.,
RA Choudhary J.S., Emes R.D., Grant S.G.;
RT "Evolution of complexity in the zebrafish synapse proteome.";
RL Nat. Commun. 8:14613-14613(2017).
RN [10] {ECO:0000313|Ensembl:ENSDARP00000150631}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000150631};
RG Ensembl;
RL Submitted (APR-2018) to UniProtKB.
RN [11] {ECO:0000313|RefSeq:NP_958888.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: GTP-binding protein involved in protein trafficking;
CC modulates vesicle budding and uncoating within the Golgi apparatus.
CC {ECO:0000256|RuleBase:RU369003}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000256|RuleBase:RU369003}.
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Arf family.
CC {ECO:0000256|ARBA:ARBA00010290, ECO:0000256|RuleBase:RU003925}.
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DR EMBL; CT737151; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC046063; AAH46063.1; -; mRNA.
DR EMBL; BC062853; AAH62853.1; -; mRNA.
DR EMBL; AY577008; AAS92646.1; -; mRNA.
DR RefSeq; NP_958888.1; NM_201480.1.
DR STRING; 7955.ENSDARP00000004127; -.
DR PaxDb; 7955-ENSDARP00000004127; -.
DR Ensembl; ENSDART00000007381.8; ENSDARP00000004127.5; ENSDARG00000016393.8.
DR Ensembl; ENSDART00000135898.3; ENSDARP00000116959.1; ENSDARG00000016393.8.
DR Ensembl; ENSDART00000136057.3; ENSDARP00000113756.1; ENSDARG00000016393.8.
DR Ensembl; ENSDART00000179898.1; ENSDARP00000150631.1; ENSDARG00000056582.8.
DR GeneID; 327026; -.
DR KEGG; dre:327026; -.
DR AGR; ZFIN:ZDB-GENE-030131-5234; -.
DR CTD; 327026; -.
DR ZFIN; ZDB-GENE-030131-5234; arf2b.
DR eggNOG; KOG0070; Eukaryota.
DR OMA; QEVRIVM; -.
DR OrthoDB; 5474610at2759; -.
DR TreeFam; TF300808; -.
DR Proteomes; UP000000437; Chromosome 24.
DR Bgee; ENSDARG00000016393; Expressed in blastula and 23 other cell types or tissues.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003924; F:GTPase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0007249; P:canonical NF-kappaB signal transduction; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:UniProtKB-UniRule.
DR CDD; cd04150; Arf1_5_like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR045872; Arf1-5-like.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR006689; Small_GTPase_ARF/SAR.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR11711; ADP RIBOSYLATION FACTOR-RELATED; 1.
DR PANTHER; PTHR11711:SF449; ADP-RIBOSYLATION FACTOR 2; 1.
DR Pfam; PF00025; Arf; 1.
DR PRINTS; PR00328; SAR1GTPBP.
DR SMART; SM00177; ARF; 1.
DR SMART; SM00175; RAB; 1.
DR SMART; SM00178; SAR; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51417; ARF; 1.
PE 1: Evidence at protein level;
KW ER-Golgi transport {ECO:0000256|ARBA:ARBA00022892,
KW ECO:0000256|RuleBase:RU369003};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034,
KW ECO:0000256|RuleBase:RU369003};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134, ECO:0000256|RuleBase:RU003925};
KW Lipoprotein {ECO:0000256|RuleBase:RU369003};
KW Myristate {ECO:0000256|ARBA:ARBA00022707, ECO:0000256|RuleBase:RU369003};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU003925};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW ECO:0000256|RuleBase:RU369003};
KW Proteomics identification {ECO:0007829|PeptideAtlas:Q7ZUZ7};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU369003}.
SQ SEQUENCE 181 AA; 20609 MW; A5D0437CA2E11A71 CRC64;
MGNVFANLFK GLFGKKEMRI LMVGLDAAGK TTILYKLKLG EIVTTIPTIG FNVETVEYKN
ISFTVWDVGG QDKIRPLWRH YFQNTQGLIF VVDSNDRERV NEAREELTRM LAEDELRDAV
LLVFANKQDL PNAMNAAEIT DKLGLHALRH RNWYIQATCA TSGDGLYEGL DWLSNQLKNQ
K
//
