ID Q7ZXE5_XENLA Unreviewed; 651 AA.
AC Q7ZXE5;
DT 01-JUN-2003, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2003, sequence version 1.
DT 27-MAR-2024, entry version 95.
DE SubName: Full=X-ray repair complementing defective repair in Chinese hamster cells 1 L homeolog {ECO:0000313|RefSeq:NP_001080711.1};
DE SubName: Full=Xrcc1-prov protein {ECO:0000313|EMBL:AAH45032.1};
GN Name=xrcc1.L {ECO:0000313|RefSeq:NP_001080711.1,
GN ECO:0000313|Xenbase:XB-GENE-6256535};
GN Synonyms=rcc {ECO:0000313|RefSeq:NP_001080711.1}, xrcc1
GN {ECO:0000313|RefSeq:NP_001080711.1,
GN ECO:0000313|Xenbase:XB-GENE-6256535};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|EMBL:AAH45032.1};
RN [1] {ECO:0000313|RefSeq:NP_001080711.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12454917; DOI=10.1002/dvdy.10174;
RA Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W.,
RA Richardson P.;
RT "Genetic and genomic tools for Xenopus research: The NIH Xenopus
RT initiative.";
RL Dev. Dyn. 225:384-391(2002).
RN [2] {ECO:0000313|EMBL:AAH45032.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo {ECO:0000313|EMBL:AAH45032.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|RefSeq:NP_001080711.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; BC045032; AAH45032.1; -; mRNA.
DR RefSeq; NP_001080711.1; NM_001087242.1.
DR GeneID; 380403; -.
DR KEGG; xla:380403; -.
DR AGR; Xenbase:XB-GENE-6256535; -.
DR CTD; 380403; -.
DR Xenbase; XB-GENE-6256535; xrcc1.L.
DR OrthoDB; 1334125at2759; -.
DR Proteomes; UP000186698; Chromosome 7L.
DR Bgee; 380403; Expressed in neurula embryo and 19 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0006284; P:base-excision repair; IEA:InterPro.
DR GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:InterPro.
DR GO; GO:0000012; P:single strand break repair; IEA:InterPro.
DR CDD; cd17725; BRCT_XRCC1_rpt1; 1.
DR CDD; cd17707; BRCT_XRCC1_rpt2; 1.
DR Gene3D; 3.40.50.10190; BRCT domain; 2.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR InterPro; IPR045080; BRCT_XRCC1_rpt1.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR002706; Xrcc1_N.
DR PANTHER; PTHR11370:SF6; DNA REPAIR PROTEIN XRCC1; 1.
DR PANTHER; PTHR11370; DNA-REPAIR PROTEIN XRCC1; 1.
DR Pfam; PF00533; BRCT; 1.
DR Pfam; PF16589; BRCT_2; 1.
DR Pfam; PF01834; XRCC1_N; 1.
DR SMART; SM00292; BRCT; 2.
DR SUPFAM; SSF52113; BRCT domain; 2.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR PROSITE; PS50172; BRCT; 2.
PE 2: Evidence at transcript level;
KW Reference proteome {ECO:0000313|Proteomes:UP000186698}.
FT DOMAIN 316..404
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT DOMAIN 556..647
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT REGION 173..315
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 408..547
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 173..196
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 203..241
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 242..269
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 293..315
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 421..484
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 491..529
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 651 AA; 73262 MW; 34A687C1C274103F CRC64;
MPVIKLKHVV SCSSADTTHT AENLLKADTY RKWKAARPGE KQISLILQFE KEEQIHSIDI
GNEGSAFVEV LVGRSTSVSE QEYEVLLGMS SFMSPSESKN ESSLNRTRMF GPDKLVKGAA
EKNWDRVKIV CTQPYTKNLA YGLSFIRLNS PPEDGSPTDP SPKLTKLGQF MVKEEENSSP
SMLPGSLFFN RTSKPQVTPP KTPPATQSYA AAALQGTAES SSSTEKQTVK TPPSNNMTKE
PSSGKRKFEF NKEPSSHSTV KKPEVKESPS STKESLSQPV PKKPKVETHT VAPTKKPSPS
EKPTQKKSPS APQSMELGRI LQGTVFVLSG FQNPFRADLR DKALEMGAKY RPDWTPDSTH
LICAFANTPK FSQVKAAGGI IVRKEWVLDC YKKRQRLPYK QYLLGAAESS SEEEDDSDED
EPPKAPLHKP HPDPSRTNHK KPLPSPAKAK EKRAPIKSED EDTEDENPRL VPSKANHAIK
QEDEYDASTD EETTGDRQRH QDDSGEDTED ELRRFQEEKQ RKKAAVKVEP EDPYAGSTDE
NTDVEEQKEL DLPIPELPDL FLGKKFFLYG EFPAAERRML LRYIIAFNGE LEEYMNEKVQ
FVITAQEWDD SFEDALNENE NVSFVRPRWI YNCNDRQKCI PHQPYVVVPK A
//
