ID Q82EG5_STRAW Unreviewed; 486 AA.
AC Q82EG5;
DT 01-JUN-2003, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2003, sequence version 1.
DT 27-MAR-2024, entry version 118.
DE SubName: Full=Aldehyde dehydrogenase {ECO:0000313|EMBL:BAC72362.1};
GN ORFNames=SAVERM_4650 {ECO:0000313|EMBL:BAC72362.1};
OS Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC
OS 14893 / NCIMB 12804 / NRRL 8165 / MA-4680).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=227882 {ECO:0000313|EMBL:BAC72362.1, ECO:0000313|Proteomes:UP000000428};
RN [1] {ECO:0000313|EMBL:BAC72362.1, ECO:0000313|Proteomes:UP000000428}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 /
RC NRRL 8165 / MA-4680 {ECO:0000313|Proteomes:UP000000428};
RX PubMed=11572948; DOI=10.1073/pnas.211433198;
RA Omura S., Ikeda H., Ishikawa J., Hanamoto A., Takahashi C., Shinose M.,
RA Takahashi Y., Horikawa H., Nakazawa H., Osonoe T., Kikuchi H., Shiba T.,
RA Sakaki Y., Hattori M.;
RT "Genome sequence of an industrial microorganism Streptomyces avermitilis:
RT deducing the ability of producing secondary metabolites.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:12215-12220(2001).
RN [2] {ECO:0000313|EMBL:BAC72362.1, ECO:0000313|Proteomes:UP000000428}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 /
RC NRRL 8165 / MA-4680 {ECO:0000313|Proteomes:UP000000428};
RX PubMed=12692562; DOI=10.1038/nbt820;
RA Ikeda H., Ishikawa J., Hanamoto A., Shinose M., Kikuchi H., Shiba T.,
RA Sakaki Y., Hattori M., Omura S.;
RT "Complete genome sequence and comparative analysis of the industrial
RT microorganism Streptomyces avermitilis.";
RL Nat. Biotechnol. 21:526-531(2003).
CC -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00009986, ECO:0000256|RuleBase:RU003345}.
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DR EMBL; BA000030; BAC72362.1; -; Genomic_DNA.
DR RefSeq; WP_010986074.1; NZ_JZJK01000062.1.
DR AlphaFoldDB; Q82EG5; -.
DR KEGG; sma:SAVERM_4650; -.
DR eggNOG; COG1012; Bacteria.
DR HOGENOM; CLU_005391_1_0_11; -.
DR OrthoDB; 6882680at2; -.
DR Proteomes; UP000000428; Chromosome.
DR GO; GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR InterPro; IPR016161; Ald_DH/histidinol_DH.
DR InterPro; IPR016163; Ald_DH_C.
DR InterPro; IPR016160; Ald_DH_CS_CYS.
DR InterPro; IPR029510; Ald_DH_CS_GLU.
DR InterPro; IPR016162; Ald_DH_N.
DR InterPro; IPR015590; Aldehyde_DH_dom.
DR PANTHER; PTHR42986; BENZALDEHYDE DEHYDROGENASE YFMT; 1.
DR PANTHER; PTHR42986:SF1; BENZALDEHYDE DEHYDROGENASE YFMT; 1.
DR Pfam; PF00171; Aldedh; 1.
DR SUPFAM; SSF53720; ALDH-like; 1.
DR PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU003345};
KW Reference proteome {ECO:0000313|Proteomes:UP000000428}.
FT DOMAIN 26..475
FT /note="Aldehyde dehydrogenase"
FT /evidence="ECO:0000259|Pfam:PF00171"
FT ACT_SITE 254
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10007"
SQ SEQUENCE 486 AA; 51937 MW; 036550EAB91E385C CRC64;
MSSYFTDLAQ QYIGGEWRPG TGSWDIIDFN PYDGEKLASI TIATVDEVDE AYRAAAAAQK
EWAATNAYAR RAVFQRALRL IEDREAEITE AIIAELGGTH LKAGFELHLA KQFLLESINL
ALRPEGRIIP SPVDGKENRL YRVPVGVVGV ISPFNFPFLL SLKSVAPALA LGNGVVLKPH
QNTPIVGGSL IAKIFEDAGL PGGLLNVVIT DIAEIGDAFL EHPVPKVISF TGSDKVGRHV
ATVCAAQFKR SVLELGGNSA LVVLEDADID YAVDAAVFSR YVHQGQVCMA ANRVLVDRSI
EAEFTEKFVA KVKTLKSGDP RDPQTIIGPV INSSQADAIS GAVDQAIADG AIALVHGTTT
DNLVEPSVLT GLAADAPILQ EEIFGPVALL IPFEGEEEAV RIVNDTPYGL SGAVHTADVE
RGVAFAKQID TGMFHVNDGT VHDEPLVAFG GEKSSGIGRL NGEATVESFT TQKWISVQHG
RSFFPF
//
