ID Q82YG2_STRAW Unreviewed; 677 AA.
AC Q82YG2;
DT 01-JUN-2003, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2003, sequence version 1.
DT 27-MAR-2024, entry version 116.
DE SubName: Full=HNH endonuclease {ECO:0000313|EMBL:BAC75302.1};
GN ORFNames=SAVERM_1p18 {ECO:0000313|EMBL:BAC75302.1};
OS Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC
OS 14893 / NCIMB 12804 / NRRL 8165 / MA-4680).
OG Plasmid SAP1 {ECO:0000313|EMBL:BAC75302.1,
OG ECO:0000313|Proteomes:UP000000428}.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=227882 {ECO:0000313|EMBL:BAC75302.1, ECO:0000313|Proteomes:UP000000428};
RN [1] {ECO:0000313|Proteomes:UP000000428}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 /
RC NRRL 8165 / MA-4680 {ECO:0000313|Proteomes:UP000000428};
RC PLASMID=Plasmid SAP1 {ECO:0000313|Proteomes:UP000000428};
RX PubMed=11572948; DOI=10.1073/pnas.211433198;
RA Omura S., Ikeda H., Ishikawa J., Hanamoto A., Takahashi C., Shinose M.,
RA Takahashi Y., Horikawa H., Nakazawa H., Osonoe T., Kikuchi H., Shiba T.,
RA Sakaki Y., Hattori M.;
RT "Genome sequence of an industrial microorganism Streptomyces avermitilis:
RT deducing the ability of producing secondary metabolites.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:12215-12220(2001).
RN [2] {ECO:0000313|EMBL:BAC75302.1, ECO:0000313|Proteomes:UP000000428}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 /
RC NRRL 8165 / MA-4680 {ECO:0000313|Proteomes:UP000000428};
RC PLASMID=Plasmid SAP1 {ECO:0000313|Proteomes:UP000000428};
RX PubMed=12692562; DOI=10.1038/nbt820;
RA Ikeda H., Ishikawa J., Hanamoto A., Shinose M., Kikuchi H., Shiba T.,
RA Sakaki Y., Hattori M., Omura S.;
RT "Complete genome sequence and comparative analysis of the industrial
RT microorganism Streptomyces avermitilis.";
RL Nat. Biotechnol. 21:526-531(2003).
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DR EMBL; AP005645; BAC75302.1; -; Genomic_DNA.
DR RefSeq; WP_011109672.1; NC_004719.1.
DR AlphaFoldDB; Q82YG2; -.
DR KEGG; sma:SAVERM_1p18; -.
DR eggNOG; COG1061; Bacteria.
DR HOGENOM; CLU_405918_0_0_11; -.
DR Proteomes; UP000000428; Plasmid SAP1.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd00085; HNHc; 1.
DR Gene3D; 1.10.30.50; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR006935; Helicase/UvrB_N.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR002711; HNH.
DR InterPro; IPR003615; HNH_nuc.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR47396:SF1; ATP-DEPENDENT HELICASE IRC3-RELATED; 1.
DR PANTHER; PTHR47396; TYPE I RESTRICTION ENZYME ECOKI R PROTEIN; 1.
DR Pfam; PF01844; HNH; 1.
DR Pfam; PF04851; ResIII; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00507; HNHc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW Endonuclease {ECO:0000313|EMBL:BAC75302.1};
KW Hydrolase {ECO:0000313|EMBL:BAC75302.1};
KW Nuclease {ECO:0000313|EMBL:BAC75302.1};
KW Plasmid {ECO:0000313|EMBL:BAC75302.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000428}.
FT DOMAIN 92..282
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 358..516
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 584..610
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 677 AA; 75549 MW; 03C1F57E69303C9C CRC64;
MADRDPQRFF TQNQRNILYD LAEGRCETCS APLLDGWEAD HMVPWVQGGR TVIENGQALC
AQCNKGKGRG VQYTDEFSPR PFQREVIDQV FDRIHAGERL TAVLASPGSG KTLTYQATAT
RLFRAGLIDH VAVFAPRVTL AEQCETDWMQ RDSQGSVTKG DCLLFDSTKR IGMIRHKIKE
KPLTPVTEPG SGFISTYSAL VTNESVFLEW AAKHQGRFLL VADEAQFCGD TTDPDAGEGG
TRAGALIKQM HEYARHTLLL TGTPNRADNQ RLVLADYEPH PTDPKREVLV HHAEAKYSNG
IAEGYLRKFE MRLTNARVSK RTLADDAGRG DSVLEYNLSD DGSELVPVLR DEKTWQPLVD
DVVRAIRDKQ KFHASYRGLI SCMQQQDAKK VYKYLQQRYP DLRVALAVSS DTGASKILQD
FKVKPMDLLV TVRMAFIGYD CKTITVVGIL THYRDGGHLM QLIGRGLRVW DGTPAREQTC
LIVAPDDPKM QGFLDLLREE NDRGLKVLEE REQEEREEPG DAVQEEFSYI DSAVATTTRA
SSNELDMDAD ETLMVETLKR AVDAAEDVTK LKQIIEMAGM MLKQPTPVPQ PRTEPEPEPP
TEAPKTERQK IADFNSKTSD TIRQYLYRGG VKPGDAGYRD AAMKATARVN EAAGCTAANA
NTVEKASRRF RAALALK
//
