ID Q837Q4_ENTFA Unreviewed; 595 AA.
AC Q837Q4;
DT 01-JUN-2003, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2003, sequence version 1.
DT 27-MAR-2024, entry version 100.
DE SubName: Full=Glycerophosphoryl diester phosphodiesterase family protein {ECO:0000313|EMBL:AAO80594.1};
GN OrderedLocusNames=EF_0779 {ECO:0000313|EMBL:AAO80594.1};
OS Enterococcus faecalis (strain ATCC 700802 / V583).
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Enterococcaceae;
OC Enterococcus.
OX NCBI_TaxID=226185 {ECO:0000313|EMBL:AAO80594.1, ECO:0000313|Proteomes:UP000001415};
RN [1] {ECO:0000313|EMBL:AAO80594.1, ECO:0000313|Proteomes:UP000001415}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700802 / V583 {ECO:0000313|Proteomes:UP000001415};
RX PubMed=12663927; DOI=10.1126/science.1080613;
RA Paulsen I., Banerjei L., Myers G.S.A., Nelson K.E., Seshadri R., Read T.D.,
RA Fouts D.E., Eisen J.A., Gill S.R., Heidelberg J.F., Tettelin H.,
RA Dodson R.J., Umayam L., Brinkac L., Beanan M., Daugherty S., DeBoy R.T.,
RA Durkin S., Kolonay J., Madupu R., Nelson W., Vamathevan J., Tran B.,
RA Upton J., Hansen T., Shetty J., Khouri H., Utterback T., Radune D.,
RA Ketchum K.A., Dougherty B.A., Fraser C.M.;
RT "Role of mobile DNA in the evolution of vancomycin-resistant Enterococcus
RT faecalis.";
RL Science 299:2071-2074(2003).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE016830; AAO80594.1; -; Genomic_DNA.
DR RefSeq; NP_814524.1; NC_004668.1.
DR RefSeq; WP_002363211.1; NZ_KE136527.1.
DR AlphaFoldDB; Q837Q4; -.
DR STRING; 226185.EF_0779; -.
DR EnsemblBacteria; AAO80594; AAO80594; EF_0779.
DR GeneID; 60893070; -.
DR KEGG; efa:EF0779; -.
DR PATRIC; fig|226185.45.peg.2717; -.
DR eggNOG; COG0584; Bacteria.
DR eggNOG; COG4781; Bacteria.
DR HOGENOM; CLU_030006_15_2_9; -.
DR Proteomes; UP000001415; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008081; F:phosphoric diester hydrolase activity; IEA:InterPro.
DR GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR CDD; cd08579; GDPD_memb_like; 1.
DR Gene3D; 3.20.20.190; Phosphatidylinositol (PI) phosphodiesterase; 1.
DR InterPro; IPR018476; GlyceroP-diester-Pdiesterase_M.
DR InterPro; IPR030395; GP_PDE_dom.
DR InterPro; IPR017946; PLC-like_Pdiesterase_TIM-brl.
DR PANTHER; PTHR46211; GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE; 1.
DR PANTHER; PTHR46211:SF8; PHOSPHODIESTERASE-RELATED; 1.
DR Pfam; PF03009; GDPD; 1.
DR Pfam; PF10110; GPDPase_memb; 1.
DR SUPFAM; SSF51695; PLC-like phosphodiesterases; 1.
DR PROSITE; PS51704; GP_PDE; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001415};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 21..42
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 68..96
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 125..145
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 165..187
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 221..242
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 262..288
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 309..333
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 341..569
FT /note="GP-PDE"
FT /evidence="ECO:0000259|PROSITE:PS51704"
SQ SEQUENCE 595 AA; 67934 MW; 5090F4AF40D33755 CRC64;
MSAWQTFKNG TRQFFKDILQ YLWLFFTLNV LLLLVGGAFS WATSNALKTQ GIPYLSFNNL
NLLLEKPLAL VLLILLLLLF LGAVFYQFTF LLLGIFQIRQ DHRFHFKGVT KASFKVLKKQ
GARSWLFFFG YFVVIVPFGN LIFQSNLLTK FVIPDFIVEF LSQRIPYLVG LLAFGLLVWY
LAIRFIYTLP LMILERKKAG EAVKASWSMT NKRLWFIIRN IAFVTIAVFV STYVIYVLLY
LLQLKLDTLS DTISLLGGIL NLTVVQFLQF VSNAWLSVLL INFLYTQLNV QAETTTKVAF
DKETKRNKLV TIGMGLGLFT IFGGYIIFNA VYLTGLLESK PLIISHRGVT NSNGVQNTIP
AMERTIKFKP DYIEIDVQET KDHQFVVMHD ANLQELAGVD GTPQEFTLAE LTKMTVKENG
QEAPIASFDD YLAKANQAKQ KLLVEIKTSK QDSQGALSNF IEKYERPLIK NNHQVQSLDY
NVIKAFKKAK SKVKVSFILP YNFTFPETQA DLYTMEATTL NDTFILKADQ QKKAVYAWTV
NDSEVLSKML FMDVAGVITD DLELVNEEVN DFEKNPSYAD RILHYIFMLP SVASQ
//
