ID Q84DL9_LISWE Unreviewed; 522 AA.
AC Q84DL9;
DT 01-JUN-2003, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2003, sequence version 1.
DT 28-JUN-2023, entry version 62.
DE RecName: Full=Probable endopeptidase p60 {ECO:0000256|ARBA:ARBA00013385};
DE AltName: Full=Invasion-associated protein p60 {ECO:0000256|ARBA:ARBA00032855};
GN Name=iap {ECO:0000313|EMBL:AAO83983.1};
OS Listeria welshimeri.
OC Bacteria; Bacillota; Bacilli; Bacillales; Listeriaceae; Listeria.
OX NCBI_TaxID=1643 {ECO:0000313|EMBL:AAO83983.1};
RN [1] {ECO:0000313|EMBL:AAO83983.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=TUMLis35 {ECO:0000313|EMBL:AAO83983.1};
RA Schmid M.W., Walcher M., Bubert A., Wagner M., Schleifer K.-H.;
RL Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AAO83983.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=TUMLis35 {ECO:0000313|EMBL:AAO83983.1};
RX PubMed=12648840; DOI=10.1016/S0928-8244(02)00456-X;
RA Schmid M., Walcher M., Bubert A., Wagner M., Wagner M., Schleifer K.-H.;
RT "Nucleic acid-based, cultivation-independent detection of Listeria spp and
RT genotypes of L monocytogenes.";
RL FEMS Immunol. Med. Microbiol. 35:215-225(2003).
CC -!- FUNCTION: This major extracellular protein may be involved in the
CC invasion of non-professional phagocytic cells by Listeria.
CC {ECO:0000256|ARBA:ARBA00003740}.
CC -!- SIMILARITY: Belongs to the peptidase C40 family.
CC {ECO:0000256|ARBA:ARBA00007074}.
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DR EMBL; AF532301; AAO83983.1; -; Genomic_DNA.
DR AlphaFoldDB; Q84DL9; -.
DR GO; GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00118; LysM; 3.
DR Gene3D; 3.90.1720.10; endopeptidase domain like (from Nostoc punctiforme); 1.
DR Gene3D; 3.10.350.10; LysM domain; 3.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR018392; LysM_dom.
DR InterPro; IPR036779; LysM_dom_sf.
DR InterPro; IPR000064; NLP_P60_dom.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR003646; SH3-like_bac-type.
DR PANTHER; PTHR47053; MUREIN DD-ENDOPEPTIDASE MEPH-RELATED; 1.
DR PANTHER; PTHR47053:SF1; MUREIN DD-ENDOPEPTIDASE MEPH-RELATED; 1.
DR Pfam; PF01476; LysM; 3.
DR Pfam; PF00877; NLPC_P60; 1.
DR Pfam; PF08239; SH3_3; 1.
DR SMART; SM00257; LysM; 3.
DR SMART; SM00287; SH3b; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF54106; LysM domain; 3.
DR PROSITE; PS51782; LYSM; 3.
DR PROSITE; PS51935; NLPC_P60; 1.
DR PROSITE; PS51781; SH3B; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022807};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..522
FT /note="Probable endopeptidase p60"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5039074326"
FT DOMAIN 28..71
FT /note="LysM"
FT /evidence="ECO:0000259|PROSITE:PS51782"
FT DOMAIN 78..142
FT /note="SH3b"
FT /evidence="ECO:0000259|PROSITE:PS51781"
FT DOMAIN 196..239
FT /note="LysM"
FT /evidence="ECO:0000259|PROSITE:PS51782"
FT DOMAIN 314..357
FT /note="LysM"
FT /evidence="ECO:0000259|PROSITE:PS51782"
FT DOMAIN 404..522
FT /note="NlpC/P60"
FT /evidence="ECO:0000259|PROSITE:PS51935"
FT REGION 154..196
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 280..313
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 360..404
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 154..180
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 280..294
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 522 AA; 53956 MW; FD406804620E1E3E CRC64;
MNMKKATIAA TAGIAVTAFA APTIASASTV VVEAGDTLWG IAQSKGTTVD ALKKANNLTS
DKIVPGQKLQ VTEVASEKTE KSVSATWLNV RSGAGVDNSI VTSLKGGTKV TVEAAESNGW
NKISYGEGKT GYVNGKYLGD AVTSAPVAKQ EVKQETTKQT VPAAETKTEV KQSTPAPTAP
KAAETKTAPV VDTNATTHTV KSGDTIWALS VKYGASVQDL MSWNNLSSSS IYVGQKIAVK
QSAAKTAAPK AEVKTEAPAV EKETSTPVVK ENTNTTVKKE VTTQTQTNTT KAPAQAAKPA
PAPAPAPTVN TNASTYTVKS GDSLSKIANT FGTSVSKIKA LNNLTSDNLQ VGTVLKVKGT
VPTTNTNNNS NTTAPTTNTS NNNTSSNTST PSKNTNTNTN QGSSNSASAL IAEAQKHLGK
AYSWGGNGPT TFDCSGFTSY VFAKSGISLP RTSGAQYAST SRISESQAKP GDLVFFDYGS
GIAHVGIYVG NGQMINAQDN GVKYDNIHGS GWGKYLVGFG RV
//
