ID Q84DU2_LISSE Unreviewed; 525 AA.
AC Q84DU2;
DT 01-JUN-2003, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2003, sequence version 1.
DT 28-JUN-2023, entry version 57.
DE RecName: Full=Probable endopeptidase p60 {ECO:0000256|ARBA:ARBA00013385};
DE AltName: Full=Invasion-associated protein p60 {ECO:0000256|ARBA:ARBA00032855};
GN Name=iap {ECO:0000313|EMBL:AAO83904.1};
OS Listeria seeligeri.
OC Bacteria; Bacillota; Bacilli; Bacillales; Listeriaceae; Listeria.
OX NCBI_TaxID=1640 {ECO:0000313|EMBL:AAO83904.1};
RN [1] {ECO:0000313|EMBL:AAO83904.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=IMVW844 {ECO:0000313|EMBL:AAO83904.1};
RA Schmid M.W., Walcher M., Bubert A., Wagner M., Schleifer K.-H.;
RL Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AAO83904.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=IMVW844 {ECO:0000313|EMBL:AAO83904.1};
RX PubMed=12648840; DOI=10.1016/S0928-8244(02)00456-X;
RA Schmid M., Walcher M., Bubert A., Wagner M., Wagner M., Schleifer K.-H.;
RT "Nucleic acid-based, cultivation-independent detection of Listeria spp and
RT genotypes of L monocytogenes.";
RL FEMS Immunol. Med. Microbiol. 35:215-225(2003).
CC -!- FUNCTION: This major extracellular protein may be involved in the
CC invasion of non-professional phagocytic cells by Listeria.
CC {ECO:0000256|ARBA:ARBA00003740}.
CC -!- SIMILARITY: Belongs to the peptidase C40 family.
CC {ECO:0000256|ARBA:ARBA00007074}.
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DR EMBL; AF532222; AAO83904.1; -; Genomic_DNA.
DR AlphaFoldDB; Q84DU2; -.
DR GO; GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00118; LysM; 3.
DR Gene3D; 3.90.1720.10; endopeptidase domain like (from Nostoc punctiforme); 1.
DR Gene3D; 3.10.350.10; LysM domain; 3.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR018392; LysM_dom.
DR InterPro; IPR036779; LysM_dom_sf.
DR InterPro; IPR000064; NLP_P60_dom.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR003646; SH3-like_bac-type.
DR PANTHER; PTHR47053; MUREIN DD-ENDOPEPTIDASE MEPH-RELATED; 1.
DR PANTHER; PTHR47053:SF1; MUREIN DD-ENDOPEPTIDASE MEPH-RELATED; 1.
DR Pfam; PF01476; LysM; 3.
DR Pfam; PF00877; NLPC_P60; 1.
DR Pfam; PF08239; SH3_3; 1.
DR SMART; SM00257; LysM; 3.
DR SMART; SM00287; SH3b; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF54106; LysM domain; 3.
DR PROSITE; PS51782; LYSM; 3.
DR PROSITE; PS51935; NLPC_P60; 1.
DR PROSITE; PS51781; SH3B; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022807};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..525
FT /note="Probable endopeptidase p60"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5038740297"
FT DOMAIN 28..71
FT /note="LysM"
FT /evidence="ECO:0000259|PROSITE:PS51782"
FT DOMAIN 78..142
FT /note="SH3b"
FT /evidence="ECO:0000259|PROSITE:PS51781"
FT DOMAIN 198..241
FT /note="LysM"
FT /evidence="ECO:0000259|PROSITE:PS51782"
FT DOMAIN 318..361
FT /note="LysM"
FT /evidence="ECO:0000259|PROSITE:PS51782"
FT DOMAIN 407..525
FT /note="NlpC/P60"
FT /evidence="ECO:0000259|PROSITE:PS51935"
FT REGION 147..189
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 251..318
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 364..413
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 268..300
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 525 AA; 54059 MW; 9BC71D86A5F4480C CRC64;
MNMKKATIAA TAGIAVTAFA APTIASASTV VVEAGDTLWG IAQDNGTTVD ALKKANKLTT
DKIVPGQKLQ VTEVASEKTE KSVSATWLNV RSGAGVDNSI VTSLKGGTKV TVESTEANGW
NKITYGEGKT GYVNGKYLGN AVTSAPSATP EVKQETTTQA APAQQTKTEV KQATPAATTE
KEAVETKTTA PAVDTNATTH TVNSGDTIWA LSVKYGASVQ DLMSWNNLSS SSIYVGQNIA
VKQSAAKNTA PKAEAKTEAP AAEKQTAAPV VNRSTNTSTT TTVKTETTTE KQTSTTKAPA
QAAKPAPAPA PTVNTNASSY TVKRGDTLGK IASTFGTTVS KIKALNGLTS DNLQVGDVLK
VKGTVPATNT NTNNATAPTT NTNNNSSSSN TSTPSKNNNS NQSSSNSSSA SAITAEAQKH
LGKAYSWGGN GPTTFDCSGF TSYVFAQSGI TLPRTSGAQY ASTTKVSESQ AKPGDLVFFD
YGSGIAHVGI YVGNGQMINA QDNGVKYDNI HGSGWGQYLV GFGRV
//
