ID Q865R5_CAPHI Unreviewed; 131 AA.
AC Q865R5;
DT 01-JUN-2003, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2003, sequence version 1.
DT 27-MAR-2024, entry version 79.
DE RecName: Full=Sex-determining region Y protein {ECO:0000256|ARBA:ARBA00019052};
DE AltName: Full=Testis-determining factor {ECO:0000256|ARBA:ARBA00032498};
DE Flags: Fragment;
GN Name=SRY {ECO:0000313|EMBL:BAC66699.1};
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925 {ECO:0000313|EMBL:BAC66699.1};
RN [1] {ECO:0000313|EMBL:BAC66699.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Testis {ECO:0000313|EMBL:BAC66699.1};
RA Kodama T., Muraoka H., Nakahori Y., Nakagome Y., Tanaka S., Tojo H.,
RA Tachi C.;
RT "On the cloning of goat (Capra hircus) SRY promotor region.";
RL Submitted (JUN-1995) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Transcriptional regulator that controls a genetic switch in
CC male development. It is necessary and sufficient for initiating male
CC sex determination by directing the development of supporting cell
CC precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells.
CC Involved in different aspects of gene regulation including promoter
CC activation or repression. Binds to the DNA consensus sequence 5'-
CC [AT]AACAA[AT]-3'. SRY HMG box recognizes DNA by partial intercalation
CC in the minor groove and promotes DNA bending. Also involved in pre-mRNA
CC splicing (By similarity). In male adult brain involved in the
CC maintenance of motor functions of dopaminergic neurons.
CC {ECO:0000256|ARBA:ARBA00025418}.
CC -!- SUBUNIT: Interacts with CALM, EP300, HDAC3, KPNB1, ZNF208 isoform KRAB-
CC O, PARP1, SLC9A3R2 and WT1. The interaction with EP300 modulates its
CC DNA-binding activity. The interaction with KPNB1 is sensitive to
CC dissociation by Ran in the GTP-bound form. Interaction with PARP1
CC impaired its DNA-binding activity. {ECO:0000256|ARBA:ARBA00024048}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus speckle {ECO:0000256|ARBA:ARBA00004324}.
CC -!- SIMILARITY: Belongs to the SRY family. {ECO:0000256|ARBA:ARBA00005998}.
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DR EMBL; D58423; BAC66699.1; -; Genomic_DNA.
DR AlphaFoldDB; Q865R5; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.30.10; High mobility group box domain; 1.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR PANTHER; PTHR10270:SF199; SEX-DETERMINING REGION Y PROTEIN; 1.
DR PANTHER; PTHR10270; SOX TRANSCRIPTION FACTOR; 1.
DR Pfam; PF00505; HMG_box; 1.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF47095; HMG-box; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00267}; Nucleus {ECO:0000256|PROSITE-ProRule:PRU00267};
KW Sexual differentiation {ECO:0000256|ARBA:ARBA00022928};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 65..131
FT /note="HMG box"
FT /evidence="ECO:0000259|PROSITE:PS50118"
FT DNA_BIND 65..131
FT /note="HMG box"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00267"
FT NON_TER 131
FT /evidence="ECO:0000313|EMBL:BAC66699.1"
SQ SEQUENCE 131 AA; 15254 MW; D21D4736B8276C6E CRC64;
MNRTVQSYAS AMFRVLKDDV YSPAVVQQQN TFAFGKTSSL CTDNHSANDQ CERGENVTES
SQDHVKRPMN AFIVWSRERR RKVALENPKL QNSEISKQLG YEWKRLTDAE KRPFFEEAQR
LLAIHRDKYP G
//
