ID Q86IU8_DICDI Unreviewed; 1313 AA.
AC Q86IU8; Q556D3;
DT 01-JUN-2003, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2003, sequence version 1.
DT 27-MAR-2024, entry version 110.
DE RecName: Full=Glycosyltransferase {ECO:0008006|Google:ProtNLM};
GN Name=gtr1 {ECO:0000313|EMBL:EAL70079.1};
GN ORFNames=DDB_G0274373 {ECO:0000313|EMBL:EAL70079.1};
OS Dictyostelium discoideum (Social amoeba).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689 {ECO:0000313|EMBL:EAL70079.1, ECO:0000313|Proteomes:UP000002195};
RN [1] {ECO:0000313|EMBL:EAL70079.1, ECO:0000313|Proteomes:UP000002195}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4 {ECO:0000313|EMBL:EAL70079.1,
RC ECO:0000313|Proteomes:UP000002195};
RX PubMed=12097910; DOI=10.1038/nature00847;
RG Dictyostelium Genome Sequencing Consortium;
RA Glockner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2] {ECO:0000313|EMBL:EAL70079.1, ECO:0000313|Proteomes:UP000002195}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4 {ECO:0000313|EMBL:EAL70079.1,
RC ECO:0000313|Proteomes:UP000002195};
RX PubMed=15875012; DOI=10.1038/nature03481;
RG The Dictyostelium discoideum Sequencing Consortium;
RA Eichinger L., Pachebat J.A., Glockner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M., Spiegler S., Tivey A., Sugano S.,
RA White B., Walker D., Woodward J., Winckler T., Tanaka Y., Shaulsky G.,
RA Schleicher M., Weinstock G., Rosenthal A., Cox E.C., Chisholm R.L.,
RA Gibbs R., Loomis W.F., Platzer M., Kay R.R., Williams J., Dear P.H.,
RA Noegel A.A., Barrell B., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the bZIP family.
CC {ECO:0000256|ARBA:ARBA00007163}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAL70079.1}.
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DR EMBL; AAFI02000012; EAL70079.1; -; Genomic_DNA.
DR RefSeq; XP_643877.1; XM_638785.1.
DR AlphaFoldDB; Q86IU8; -.
DR STRING; 44689.Q86IU8; -.
DR PaxDb; 44689-DDB0231868; -.
DR GeneID; 8619303; -.
DR KEGG; ddi:DDB_G0274373; -.
DR dictyBase; DDB_G0274373; gtr1.
DR eggNOG; ENOG502RZ8Y; Eukaryota.
DR HOGENOM; CLU_260547_0_0_1; -.
DR InParanoid; Q86IU8; -.
DR OMA; FWHYVRL; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0016757; F:glycosyltransferase activity; IEA:InterPro.
DR GO; GO:0008146; F:sulfotransferase activity; IEA:InterPro.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR Gene3D; 3.40.50.2000; Glycogen Phosphorylase B; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR001296; Glyco_trans_1.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000863; Sulfotransferase_dom.
DR PANTHER; PTHR14312; CREB/ATF BZIP TRANSCRIPTION FACTOR; 1.
DR PANTHER; PTHR14312:SF6; SAP DNA-BINDING DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR Pfam; PF00534; Glycos_transf_1; 1.
DR Pfam; PF00685; Sulfotransfer_1; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF53756; UDP-Glycosyltransferase/glycogen phosphorylase; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000002195};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..29
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 430..595
FT /note="Glycosyl transferase family 1"
FT /evidence="ECO:0000259|Pfam:PF00534"
FT DOMAIN 1021..1296
FT /note="Sulfotransferase"
FT /evidence="ECO:0000259|Pfam:PF00685"
FT REGION 41..80
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 789..814
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 42..80
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1313 AA; 151357 MW; 22F55C092A859C9D CRC64;
MISKIFSKQS IFAIFVICLF IFILNNNIID TKLKEKHIKE QNNNNNNNNN NNNNNNNNNN
NNNNNNNNNK NNNKKSNVKK NSYNSFRNIN FLNEEFPQLY TYNPEEQNIE TYHYYEEEEE
EEVEVEVEEG EEEEDNYQDK NKLKIFNNEI KEEWSKLPSD IMDKKRICIV TTEIEGPVLG
GGIGTAYTAL SQKLNEDGHQ ITIVLVNKVK RLTMEHWIEL YGRQGIELVI LDFFLLDPLS
VGSKVAMENQ NKLNPNETDN LIGMIGCTGP CIRSYRTYLW LSRHENQFDF IHFHDNGGMA
YFSTLSQRQG LHFQEVNIVI GGHGPHLWER IANSANLDDG KHFEVDYLER KSVQFSNYLI
SPSNYMLNWM TYNRWEIPKN SFVHQNLLPG KNQQSLSPML LNDFLFKQQQ QQQQDINADQ
QDDDNDNGLE LHDFNEILFF GRLESRKGLD IFLKALESLS QQIKSYSMKI TFLGSNTKLM
EFNVMADLYI DSVCRRLDIY CQILVGKSHT EAIQYLTTNK HDKLVVVASP IDNSPNTVLE
CLTHRLSLIA TNVGGIPELI HPNDRKRVLF DPKPKSLIKL IKTLKETGIS AARFSTDEWT
RQMIWSNWHS IAQLDSSITN RNRKLNSVRL DNIKKKLLTI VLIYDRSNLE TLLKNINSIS
SQPSPYFNYN ILIAKSSKIP GGSTDKISPK LSKLLKSLNI FYLVTEINDS LLQPFQPWNS
KEILEHSTGD NILFLDPLDY LSSNALYLLG RVDQFTNAQI ITGSVLFSGN NSIIIDKVFD
QINKNIGTTT TTTTTTTTTT TTTTTSSTTS SSLDHSPDTS ITSIYMGCTG MPGIMYNCYG
SSNLLISRVA LQELSNQYPV LKKNNSADND HFDHLDFNSD IENSGTWDFY AHATSNGYSL
QTIPKVLFIS DRLEYEPQIT YSQETRVLKN FDNILPPTFE LSSLATRHFL TTKKLYLNEI
INVNTKSKEC ERLLNSGNIN NINSNNNNNN NNQELIKISN DNFNENGEEN HMESRNHIKM
LFVRGHEKSG TSWLKKVIDL HPRIFMAKQE FHFSIMEEGL DKFTSKPWAA AQEPYKSYSR
KWYRSFVRNI LLSGVSPSLA PLINWIGEKT PSPLAPIISG SRYILIIRDG RDVVISLFWH
YVRLGGFENW CGPNQHHLVN PDYVKEYRAD NGTKDYFSIY PERLLEKEIC FRKIASGWAK
RVREDQSVID ALQSNPVASV FSLRYEELHR NPEENRKALY QFLDLDYNEA EPLSVEDKTI
PGGFDEKSDK NKFFRKGEIG DWKNYFTDNN KRWFKEETGS LLVDLGYELN NDW
//
