ID Q86NW6_DROME Unreviewed; 1191 AA.
AC Q86NW6;
DT 01-JUN-2003, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2003, sequence version 1.
DT 24-JAN-2024, entry version 117.
DE SubName: Full=GM01778p {ECO:0000313|EMBL:AAO39607.1};
GN Name=Pura {ECO:0000313|FlyBase:FBgn0035802};
GN Synonyms=CG7511 {ECO:0000313|EMBL:AAO39607.1};
GN ORFNames=CG33275 {ECO:0000313|FlyBase:FBgn0035802};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AAO39607.1};
RN [1] {ECO:0000313|EMBL:AAO39607.1}
RP NUCLEOTIDE SEQUENCE.
RA Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J., Champe M.,
RA Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E., George R.,
RA Gonzalez M., Guarin H., Kronmiller B., Li P., Liao G., Miranda A.,
RA Mungall C.J., Nunoo J., Pacleb J., Paragas V., Park S., Patel S.,
RA Phouanenavong S., Wan K., Yu C., Lewis S.E., Rubin G.M., Celniker S.;
RL Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; BT003604; AAO39607.1; -; mRNA.
DR AlphaFoldDB; Q86NW6; -.
DR AGR; FB:FBgn0035802; -.
DR FlyBase; FBgn0035802; Pura.
DR VEuPathDB; VectorBase:FBgn0035802; -.
DR HOGENOM; CLU_001356_5_1_1; -.
DR ExpressionAtlas; Q86NW6; baseline and differential.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; ISS:FlyBase.
DR GO; GO:0007480; P:imaginal disc-derived leg morphogenesis; IMP:FlyBase.
DR GO; GO:0048812; P:neuron projection morphogenesis; IMP:FlyBase.
DR GO; GO:0035025; P:positive regulation of Rho protein signal transduction; ISS:FlyBase.
DR GO; GO:1904059; P:regulation of locomotor rhythm; IGI:FlyBase.
DR CDD; cd13242; PH_puratrophin-1; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR45845:SF3; PURATROPHIN-1-LIKE, ISOFORM A; 1.
DR PANTHER; PTHR45845; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR-RELATED; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 2: Evidence at transcript level;
KW Coiled coil {ECO:0000256|SAM:Coils}.
FT DOMAIN 636..820
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 832..943
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 18..55
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 118..139
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 523..549
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 981..1057
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1076..1119
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1136..1167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 301..332
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 118..134
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 524..539
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1006..1038
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1092..1108
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1191 AA; 132566 MW; F7DC14EE5940264B CRC64;
MATLLLYYST IPERSSCPFT TPATPGTTAT INGHKSTEQQ QQQQQQQHQQ QQQQKQQPAQ
QTFTILIAIE KSQHLCVIDL ICQSLRLLAK QIGNCEILAV CPDSSLLQLC NGQQQQKLQQ
QQQQNNNSDH PEPSSPSPVD LVKFISVDQV TTSVAPSQLP AGLLPSVPAL STLPGISQRH
HDATKWREFF AQLEAFQRQC STAGGRLVSA LSEIRAADLQ GLPTRRQLYG QHRALSRALM
DSQLHSLRKM GAGQLARLQD LARAITSAPG SPRMTSQPQS SSSSSSGAFL NVDAACKLRK
VTLLFNEVDR AAQRLEQLTE QRRERLRQLT RQRALEDEIS EVTSWLGSDG AENLQKFSQL
HWDNESQLRT QEQEFEKYYF IAMKHLAKGR DLHAAALKVS VLSESANNLK SALDQFAQKL
ELAHERYEAA GRLLHLLTQH QRENAAREEL QRLAEQLGAT SLLEKHWPVM RKTHTLPVAS
STPAAAAGKR VSYRCSSASG SSFEGGPSSS NCSCWRESRN LEDMDQMEEE EEERDHDCDG
GDGEEQQSKI ADSGVGVCDN CERNPKLARI CSCQSLNEKS HDELLEDECF DRPSKRYMDI
MHSPMEANAH LQCHGSSLEL PKLEELSCLD PKIQKTLLLI MREMIGTERD YVRSLYYVIE
NYIDELLRED IPQPLRGQRN VIFGNIEKIF EFHNSHFLGE LERYERNPLK VGAAFLEMES
KFYLYALYNK NKPKSDTLLS EYGSSFFKPK QMQLQDKLDL ASYLLKPVQR MGKYALLLQQ
LVKACKGVEG AALQEIAADV EELQRAEEMV KFQLRHGNDL LAMDSLRDCD VNVKEQGRLL
RQNEFLVWQG RGGKKTLRQV FLFEELVLFS KARRFPDHKN LDIYIYKNSI KTSDIGLTAH
TGDSATKFEI WFRKRKPDDT WMLQCMSEDI KNAWTEEISK LLWKQAKRNR EVRLAEMSSM
GIGSKPCLDI RPSNNQISDR SIPLAQLNKT PKLRHSEPGK GSMRRPNSLI SESSLSSGTS
TTSGSSISGG SSSGHNDGGG RHSLHFGKLP GAHSASSTNC SATLELINET QALKLAKSPS
GGGIKGADTA ADGGNTSGNG NGNGNAFRSS KRNHKRSTTI VSQLSMESGI VSDMCVTPDQ
EQSAAESSRS SWSTSTTGAS GASTTSASTV ILRRYRSYAH AAESASPESG K
//
