ID Q89Q68_BRADU Unreviewed; 349 AA.
AC Q89Q68;
DT 01-JUN-2003, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2003, sequence version 1.
DT 27-MAR-2024, entry version 98.
DE SubName: Full=Cobalamin synthesis protein {ECO:0000313|EMBL:BAC48527.1};
GN Name=cobW {ECO:0000313|EMBL:BAC48527.1};
OS Bradyrhizobium diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628 /
OS NBRC 14792 / USDA 110).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC Nitrobacteraceae; Bradyrhizobium.
OX NCBI_TaxID=224911 {ECO:0000313|EMBL:BAC48527.1, ECO:0000313|Proteomes:UP000002526};
RN [1] {ECO:0000313|Proteomes:UP000002526}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110
RC {ECO:0000313|Proteomes:UP000002526};
RX PubMed=12597275; DOI=10.1093/dnares/9.6.189;
RA Kaneko T., Nakamura Y., Sato S., Minamisawa K., Uchiumi T., Sasamoto S.,
RA Watanabe A., Idesawa K., Iriguchi M., Kawashima K., Kohara M.,
RA Matsumoto M., Shimpo S., Tsuruoka H., Wada T., Yamada M., Tabata S.;
RT "Complete genomic sequence of nitrogen-fixing symbiotic bacterium
RT Bradyrhizobium japonicum USDA110.";
RL DNA Res. 9:189-197(2002).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:58189;
CC Evidence={ECO:0000256|ARBA:ARBA00001702};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670;
CC Evidence={ECO:0000256|ARBA:ARBA00001702};
CC -!- SIMILARITY: Belongs to the SIMIBI class G3E GTPase family. ZNG1
CC subfamily. {ECO:0000256|ARBA:ARBA00034320}.
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DR EMBL; BA000040; BAC48527.1; -; Genomic_DNA.
DR RefSeq; NP_769902.1; NC_004463.1.
DR RefSeq; WP_011086046.1; NZ_CP011360.1.
DR AlphaFoldDB; Q89Q68; -.
DR STRING; 224911.AAV28_13345; -.
DR EnsemblBacteria; BAC48527; BAC48527; BAC48527.
DR GeneID; 64023012; -.
DR KEGG; bja:blr3261; -.
DR PATRIC; fig|224911.44.peg.2907; -.
DR eggNOG; COG0523; Bacteria.
DR HOGENOM; CLU_017452_1_0_5; -.
DR InParanoid; Q89Q68; -.
DR OrthoDB; 9808822at2; -.
DR PhylomeDB; Q89Q68; -.
DR Proteomes; UP000002526; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0009236; P:cobalamin biosynthetic process; IEA:InterPro.
DR CDD; cd03112; CobW-like; 1.
DR Gene3D; 3.30.1220.10; CobW-like, C-terminal domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR012824; CobW.
DR InterPro; IPR036627; CobW-likC_sf.
DR InterPro; IPR011629; CobW-like_C.
DR InterPro; IPR003495; CobW/HypB/UreG_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR02475; CobW; 1.
DR PANTHER; PTHR13748; COBW-RELATED; 1.
DR PANTHER; PTHR13748:SF70; PROTEIN COBW; 1.
DR Pfam; PF02492; cobW; 1.
DR Pfam; PF07683; CobW_C; 1.
DR SMART; SM00833; CobW_C; 1.
DR SUPFAM; SSF90002; Hypothetical protein YjiA, C-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000002526}.
FT DOMAIN 253..345
FT /note="CobW C-terminal"
FT /evidence="ECO:0000259|SMART:SM00833"
SQ SEQUENCE 349 AA; 36807 MW; 9667ACCEAC4FDD1C CRC64;
MNSLAKVPVT VVTGFLGSGK TTLIQHLLAN PNGKKLAVLV NEFGSEGVDG QILKSCADAN
CPEENIVELA NGCICCTVAD DFIPTMELLL ARPVRPDHIL IETSGLALPK PLLRAFDWPE
IRSRITVDGV IALADAEAVA AGRFAPDPAA VEAQRAADEN LDHETPLSEV FEDQIACADI
VLLTKADLAG PAGLEAAKAA ITAEMPRRVP MLAVTDGAID ARVILGLGAA AENDLAARPS
HHDGEEEHEH DDFASVVIDL PEVGDVDALV ASVQRLAREQ NVLRAKGYIA VAGKPMRLLL
QAVGERVRHQ FDKPWGALAR QSKLVVIGEH GDIDEAAIRA GLGLSGSGI
//
