ID Q8A0E9_BACTN Unreviewed; 849 AA.
AC Q8A0E9;
DT 01-JUN-2003, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2003, sequence version 1.
DT 27-MAR-2024, entry version 118.
DE SubName: Full=Alpha-mannosidase {ECO:0000313|EMBL:AAO79177.1};
GN OrderedLocusNames=BT_4072 {ECO:0000313|EMBL:AAO79177.1};
OS Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / JCM 5827 /
OS CCUG 10774 / NCTC 10582 / VPI-5482 / E50).
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC Bacteroides.
OX NCBI_TaxID=226186 {ECO:0000313|EMBL:AAO79177.1, ECO:0000313|Proteomes:UP000001414};
RN [1] {ECO:0000313|EMBL:AAO79177.1, ECO:0000313|Proteomes:UP000001414}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29148 / DSM 2079 / JCM 5827 / CCUG 10774 / NCTC 10582 /
RC VPI-5482 / E50 {ECO:0000313|Proteomes:UP000001414};
RX PubMed=12663928; DOI=10.1126/science.1080029;
RA Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C.,
RA Hooper L.V., Gordon J.I.;
RT "A genomic view of the human-Bacteroides thetaiotaomicron symbiosis.";
RL Science 299:2074-2076(2003).
RN [2] {ECO:0000313|EMBL:AAO79177.1, ECO:0000313|Proteomes:UP000001414}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29148 / DSM 2079 / JCM 5827 / CCUG 10774 / NCTC 10582 /
RC VPI-5482 / E50 {ECO:0000313|Proteomes:UP000001414};
RX PubMed=19321416; DOI=10.1073/pnas.0901529106;
RA Mahowald M.A., Rey F.E., Seedorf H., Turnbaugh P.J., Fulton R.S.,
RA Wollam A., Shah N., Wang C., Magrini V., Wilson R.K., Cantarel B.L.,
RA Coutinho P.M., Henrissat B., Crock L.W., Russell A., Verberkmoes N.C.,
RA Hettich R.L., Gordon J.I.;
RT "Characterizing a model human gut microbiota composed of members of its two
RT dominant bacterial phyla.";
RL Proc. Natl. Acad. Sci. U.S.A. 106:5859-5864(2009).
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 38 family.
CC {ECO:0000256|ARBA:ARBA00009792}.
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DR EMBL; AE015928; AAO79177.1; -; Genomic_DNA.
DR RefSeq; NP_812983.1; NC_004663.1.
DR RefSeq; WP_008764306.1; NC_004663.1.
DR AlphaFoldDB; Q8A0E9; -.
DR STRING; 226186.BT_4072; -.
DR CAZy; GH38; Glycoside Hydrolase Family 38.
DR PaxDb; 226186-BT_4072; -.
DR EnsemblBacteria; AAO79177; AAO79177; BT_4072.
DR GeneID; 60925247; -.
DR KEGG; bth:BT_4072; -.
DR PATRIC; fig|226186.12.peg.4137; -.
DR eggNOG; COG0383; Bacteria.
DR HOGENOM; CLU_336461_0_0_10; -.
DR InParanoid; Q8A0E9; -.
DR OrthoDB; 9772207at2; -.
DR Proteomes; UP000001414; Chromosome.
DR GO; GO:0004559; F:alpha-mannosidase activity; IBA:GO_Central.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0006013; P:mannose metabolic process; IEA:InterPro.
DR GO; GO:0009313; P:oligosaccharide catabolic process; IBA:GO_Central.
DR Gene3D; 3.20.110.10; Glycoside hydrolase 38, N terminal domain; 1.
DR Gene3D; 1.20.1270.50; Glycoside hydrolase family 38, central domain; 1.
DR Gene3D; 2.60.40.1180; Golgi alpha-mannosidase II; 1.
DR InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR InterPro; IPR011330; Glyco_hydro/deAcase_b/a-brl.
DR InterPro; IPR011682; Glyco_hydro_38_C.
DR InterPro; IPR037094; Glyco_hydro_38_cen_sf.
DR InterPro; IPR000602; Glyco_hydro_38_N.
DR InterPro; IPR027291; Glyco_hydro_38_N_sf.
DR InterPro; IPR028995; Glyco_hydro_57/38_cen_sf.
DR InterPro; IPR013780; Glyco_hydro_b.
DR PANTHER; PTHR46017; ALPHA-MANNOSIDASE 2C1; 1.
DR PANTHER; PTHR46017:SF1; ALPHA-MANNOSIDASE 2C1; 1.
DR Pfam; PF07748; Glyco_hydro_38C; 1.
DR Pfam; PF01074; Glyco_hydro_38N; 1.
DR SUPFAM; SSF88688; Families 57/38 glycoside transferase middle domain; 1.
DR SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR SUPFAM; SSF88713; Glycoside hydrolase/deacetylase; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001414}.
FT DOMAIN 13..204
FT /note="Glycoside hydrolase family 38 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01074"
FT DOMAIN 488..691
FT /note="Glycosyl hydrolase family 38 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF07748"
SQ SEQUENCE 849 AA; 97047 MW; 9D35E8DAEC0A226F CRC64;
MNRLNNIILL VVFICTHAHS QQAYFVDGYH GGIYGHYPVK WKTQFIVDQL SKHPDWRICL
EIEPETWDTV QIQTPGAYRQ LKNVVVTKQV EFTNPTYAQP YCYNISGESI IRQFQYGIAK
INKHFPGVTF TTYSVEEPCF TSCLPQILKL FGFKYAVLKC PNTCWGGYTN AYGGELVNWV
GPDGTPILTV PRYACEKLEE NSTWQTTAWC NEESYLNACR DAGIEHPVGM CFQDAGWKNG
PWLGSGKNTK SNSVYVTWKD YFENISIGKT NDDWHFSQED IRVNLMWGSQ VLQRIAQEVR
TSENKIIIAE KMSVIAHLAN GYTCVQEDLD EAWRTLMLAQ HHDSWIVPYN GLNKFGTWAD
QIKRWTDETN TVADKITAAS IFSFDNDTIN TEKAQGFVRV YNTLGTKRKE LVTVELPQEY
ADFDLEVNDY RNKKVDYSIG KEGGKIRLLF EADVPPFGYS TYRIKQVKTG KRTVSGSEKI
INEGEYVVEN DMYKIVFDLS KGGIIKSLVA KKEENKEFAK QSGEYSIGEL RGYFYDEGKF
RSSTEAPAKL TVLRSNIQET KVKLEGKIAS HPFVQIISIA QGEKRIDFDL TINWKKNVGI
GEYKENSWRD NRRAYCDDRF KLSVLFPVNL HSPRIYKNAP FDVCESKLDD TFFNSWDQIK
HNIILHWVDL AEQEGDYALA LFADHTTSYS HGKDYPLGLT AQYSGNGLWG PDYKITGPLK
MKYAIVPHRG KWDKAAIATK SDCWNEPLLC SYHSFAKLES RSLVDLKNTG YQVSAANIKD
GKIILRLFNA EGDRKQHNIT FDMPLSSIEE VDLNGRVIDR KTIKTRTGKS EISISMPRFG
LKTFALNLN
//
