ID Q8A151_BACTN Unreviewed; 620 AA.
AC Q8A151;
DT 01-JUN-2003, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2003, sequence version 1.
DT 27-MAR-2024, entry version 108.
DE SubName: Full=Penicillin-binding protein 2 (PBP-2) {ECO:0000313|EMBL:AAO78921.1};
GN OrderedLocusNames=BT_3816 {ECO:0000313|EMBL:AAO78921.1};
OS Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / JCM 5827 /
OS CCUG 10774 / NCTC 10582 / VPI-5482 / E50).
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC Bacteroides.
OX NCBI_TaxID=226186 {ECO:0000313|EMBL:AAO78921.1, ECO:0000313|Proteomes:UP000001414};
RN [1] {ECO:0000313|EMBL:AAO78921.1, ECO:0000313|Proteomes:UP000001414}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29148 / DSM 2079 / JCM 5827 / CCUG 10774 / NCTC 10582 /
RC VPI-5482 / E50 {ECO:0000313|Proteomes:UP000001414};
RX PubMed=12663928; DOI=10.1126/science.1080029;
RA Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C.,
RA Hooper L.V., Gordon J.I.;
RT "A genomic view of the human-Bacteroides thetaiotaomicron symbiosis.";
RL Science 299:2074-2076(2003).
RN [2] {ECO:0000313|EMBL:AAO78921.1, ECO:0000313|Proteomes:UP000001414}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29148 / DSM 2079 / JCM 5827 / CCUG 10774 / NCTC 10582 /
RC VPI-5482 / E50 {ECO:0000313|Proteomes:UP000001414};
RX PubMed=19321416; DOI=10.1073/pnas.0901529106;
RA Mahowald M.A., Rey F.E., Seedorf H., Turnbaugh P.J., Fulton R.S.,
RA Wollam A., Shah N., Wang C., Magrini V., Wilson R.K., Cantarel B.L.,
RA Coutinho P.M., Henrissat B., Crock L.W., Russell A., Verberkmoes N.C.,
RA Hettich R.L., Gordon J.I.;
RT "Characterizing a model human gut microbiota composed of members of its two
RT dominant bacterial phyla.";
RL Proc. Natl. Acad. Sci. U.S.A. 106:5859-5864(2009).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
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DR EMBL; AE015928; AAO78921.1; -; Genomic_DNA.
DR RefSeq; NP_812727.1; NC_004663.1.
DR RefSeq; WP_008762750.1; NZ_UYXG01000029.1.
DR AlphaFoldDB; Q8A151; -.
DR STRING; 226186.BT_3816; -.
DR PaxDb; 226186-BT_3816; -.
DR EnsemblBacteria; AAO78921; AAO78921; BT_3816.
DR GeneID; 60924986; -.
DR KEGG; bth:BT_3816; -.
DR PATRIC; fig|226186.12.peg.3880; -.
DR eggNOG; COG0768; Bacteria.
DR HOGENOM; CLU_009289_1_2_10; -.
DR InParanoid; Q8A151; -.
DR OrthoDB; 9766847at2; -.
DR Proteomes; UP000001414; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008658; F:penicillin binding; IBA:GO_Central.
DR GO; GO:0071972; F:peptidoglycan L,D-transpeptidase activity; IBA:GO_Central.
DR GO; GO:0009002; F:serine-type D-Ala-D-Ala carboxypeptidase activity; IEA:InterPro.
DR GO; GO:0071555; P:cell wall organization; IBA:GO_Central.
DR GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR005311; PBP_dimer.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR InterPro; IPR017790; Penicillin-binding_protein_2.
DR NCBIfam; TIGR03423; pbp2_mrdA; 1.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF2; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE MRDA; 1.
DR Pfam; PF03717; PBP_dimer; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001414};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..31
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 54..224
FT /note="Penicillin-binding protein dimerisation"
FT /evidence="ECO:0000259|Pfam:PF03717"
FT DOMAIN 263..583
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
SQ SEQUENCE 620 AA; 69747 MW; 1D9B177B87EBC528 CRC64;
MAKDYRLEKR KFVIGGIALT IVLIYLIRLF VLQITTDDYK KNADSNAFLN KIQYPSRGAI
YDRNGKLLVF NQPAYDITLV PKEVENLDTL DLCESLGITR AQFLKIMSDM RDRRRNPGYS
RYTNQLFMSQ LSAEECGVFQ EKLFKFPGFY IQRRTIRQYS YNAAAHALGD IGEVSVKDME
ADEEGYYIRG DYVGKLGVER SYEKYLRGEK GVEILLRDAH GRIQGRYMDG EYDRPSIPGK
NLTLSLDIDL QILGERLLKN KIGSIVAIEP ETGEILCLVS SPNYDPHLMI GRQRGKNHLM
LQRDKQKPLL NRALMGVYPP GSTFKTAQGL TFLQEGIITE QSPSFPCSRG FHYGRLTVGC
HAHGSPLPLI PAIATSCNSY FCWGLFRMFG DRKYGSPQNA ITVWKDHMVS QGFGYKLGVD
LPGEKRGLIP NAQFYDKAYR GHWNGLTVIS ISIGQGEILS TPLQIANLGA TIANRGHFTT
PHIVKEIQDA QLDSIYRHPR NTTIERRHYE SVVEGMRAAA TGGTCRMLSV MVPELEACGK
TGTAQNRGHD HSVFMGFAPM NQPKIAIAVY VENGGWGATY GVPIGALMME QYMKGKLSPE
NELRAEEISN RIILYGNEER
//
