ID Q8A4C3_BACTN Unreviewed; 1001 AA.
AC Q8A4C3;
DT 01-JUN-2003, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2003, sequence version 1.
DT 27-MAR-2024, entry version 125.
DE SubName: Full=Beta-galactosidase {ECO:0000313|EMBL:AAO77786.1};
GN OrderedLocusNames=BT_2680 {ECO:0000313|EMBL:AAO77786.1};
OS Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / JCM 5827 /
OS CCUG 10774 / NCTC 10582 / VPI-5482 / E50).
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC Bacteroides.
OX NCBI_TaxID=226186 {ECO:0000313|EMBL:AAO77786.1, ECO:0000313|Proteomes:UP000001414};
RN [1] {ECO:0000313|EMBL:AAO77786.1, ECO:0000313|Proteomes:UP000001414}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29148 / DSM 2079 / JCM 5827 / CCUG 10774 / NCTC 10582 /
RC VPI-5482 / E50 {ECO:0000313|Proteomes:UP000001414};
RX PubMed=12663928; DOI=10.1126/science.1080029;
RA Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C.,
RA Hooper L.V., Gordon J.I.;
RT "A genomic view of the human-Bacteroides thetaiotaomicron symbiosis.";
RL Science 299:2074-2076(2003).
RN [2] {ECO:0000313|EMBL:AAO77786.1, ECO:0000313|Proteomes:UP000001414}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29148 / DSM 2079 / JCM 5827 / CCUG 10774 / NCTC 10582 /
RC VPI-5482 / E50 {ECO:0000313|Proteomes:UP000001414};
RX PubMed=19321416; DOI=10.1073/pnas.0901529106;
RA Mahowald M.A., Rey F.E., Seedorf H., Turnbaugh P.J., Fulton R.S.,
RA Wollam A., Shah N., Wang C., Magrini V., Wilson R.K., Cantarel B.L.,
RA Coutinho P.M., Henrissat B., Crock L.W., Russell A., Verberkmoes N.C.,
RA Hettich R.L., Gordon J.I.;
RT "Characterizing a model human gut microbiota composed of members of its two
RT dominant bacterial phyla.";
RL Proc. Natl. Acad. Sci. U.S.A. 106:5859-5864(2009).
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 2 family.
CC {ECO:0000256|ARBA:ARBA00007401}.
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DR EMBL; AE015928; AAO77786.1; -; Genomic_DNA.
DR RefSeq; NP_811592.1; NC_004663.1.
DR RefSeq; WP_011108444.1; NC_004663.1.
DR AlphaFoldDB; Q8A4C3; -.
DR STRING; 226186.BT_2680; -.
DR CAZy; GH2; Glycoside Hydrolase Family 2.
DR PaxDb; 226186-BT_2680; -.
DR EnsemblBacteria; AAO77786; AAO77786; BT_2680.
DR GeneID; 60923851; -.
DR KEGG; bth:BT_2680; -.
DR PATRIC; fig|226186.12.peg.2721; -.
DR eggNOG; COG3250; Bacteria.
DR HOGENOM; CLU_006501_3_0_10; -.
DR InParanoid; Q8A4C3; -.
DR OrthoDB; 9801077at2; -.
DR Proteomes; UP000001414; Chromosome.
DR GO; GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR InterPro; IPR036156; Beta-gal/glucu_dom_sf.
DR InterPro; IPR032311; DUF4982.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR040605; Glyco_hydro2_dom5.
DR InterPro; IPR006103; Glyco_hydro_2_cat.
DR InterPro; IPR006102; Glyco_hydro_2_Ig-like.
DR InterPro; IPR006104; Glyco_hydro_2_N.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR013783; Ig-like_fold.
DR PANTHER; PTHR42732; BETA-GALACTOSIDASE; 1.
DR PANTHER; PTHR42732:SF1; BETA-MANNOSIDASE; 1.
DR Pfam; PF16355; DUF4982; 1.
DR Pfam; PF18565; Glyco_hydro2_C5; 1.
DR Pfam; PF00703; Glyco_hydro_2; 1.
DR Pfam; PF02836; Glyco_hydro_2_C; 1.
DR Pfam; PF02837; Glyco_hydro_2_N; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF49303; beta-Galactosidase/glucuronidase domain; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000001414}.
FT DOMAIN 34..183
FT /note="Glycosyl hydrolases family 2 sugar binding"
FT /evidence="ECO:0000259|Pfam:PF02837"
FT DOMAIN 209..311
FT /note="Glycoside hydrolase family 2 immunoglobulin-like
FT beta-sandwich"
FT /evidence="ECO:0000259|Pfam:PF00703"
FT DOMAIN 317..447
FT /note="Glycoside hydrolase family 2 catalytic"
FT /evidence="ECO:0000259|Pfam:PF02836"
FT DOMAIN 633..690
FT /note="DUF4982"
FT /evidence="ECO:0000259|Pfam:PF16355"
FT DOMAIN 712..804
FT /note="Glycoside hydrolase family 2"
FT /evidence="ECO:0000259|Pfam:PF18565"
SQ SEQUENCE 1001 AA; 114536 MW; 8632EB9D2C89583A CRC64;
MRHRILFFFL AFIGISQFVT SSDVRNKYNF NSDWLLYVGD VPEAKQPRFS DSEWKKVTLP
HAFNEDEAFR LSIDELTDTI MWYRKHFRLP ANSKNKKVFV EFEGVRQGAD FYINGQNVGL
HENGVMAVGF DLTPYIKYGQ ENVIAVRIDN DWNYKERATG TKYQWSNKNF NANYGGIPKN
VWLHVTDRLY QTLPLYSNLK TTGVYIYAED IRVKSRKAII HAESEIRNEY NRDKQVSYQV
ELIDRDGTSI QTFEGTKAVV KPGETITLKA ASEVDNLHFW SWGYGYLYTV KTSLWVDGRK
VDEVATRTGF RKTRFGKGMI WLNDRVIQMK GFAQRTSNEW PGVGMSVPAW LSDYSNHLMV
EGNANLVRWM HVTPWKQDIE SCDRVGLIQA MQAGDAEKDC EGRQWEQRTE LMRDAIIYNR
NNPSILFYEC GNESISREHM IEMKAIRDLY DPHGGRAIGS REMLDIREAE YGGEMLYINK
SAHHPMWAME YCRDEGLRKY WDDYSYPYHK DGDGSNSYKS TVTNKVQKKV DARVYNRNQD
SFTIENIIRW FDYWRERPGT GDRVSSGGVK IIFSDTNTHY RGVENYRRSG VTDAMRIPKD
PFFAHQVMWD GWVDTECPRI YIVGHWNYND TVVKPVYVVS SADKVELFLN GKSLGYGEQD
YHFLYTFKDI AFVPGRLEAV GYDENGKECC RTQLQTAGKP EQIQLSFIQS PEGWKADGAD
MVLLQVEVMD KDGNRCPLAN DLIHFEVEGP AEWRGGIAQG ENNYILSKDL PVECGINRAL
IRSLTTAGNV RITAKADGLK PAEISLTSSP VEVKNGLSNY IPGDELEGRL TRGETPQTPS
YKVSKVDVGI VSAIAGANNE STVNSFDDNE LSEWRNDGKA ATAWITYKLE RAARVDEVCM
KLTGWRMRSY PLEIYAGKEL IWSGDTDKSL GYVHLDVKPV LTNEITIRLK GTSKEGDAFG
QIVEVAAPVA NELDLFKAKD GDKTGHELRI VEIEFKENLL K
//
