ID   Q8A4M2_BACTN            Unreviewed;      1407 AA.
AC   Q8A4M2;
DT   01-JUN-2003, integrated into UniProtKB/TrEMBL.
DT   01-JUN-2003, sequence version 1.
DT   27-MAR-2024, entry version 111.
DE   SubName: Full=Peptidase, trypsin-like serine and cysteine {ECO:0000313|EMBL:AAO77684.1};
GN   OrderedLocusNames=BT_2577 {ECO:0000313|EMBL:AAO77684.1};
OS   Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / JCM 5827 /
OS   CCUG 10774 / NCTC 10582 / VPI-5482 / E50).
OC   Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC   Bacteroides.
OX   NCBI_TaxID=226186 {ECO:0000313|EMBL:AAO77684.1, ECO:0000313|Proteomes:UP000001414};
RN   [1] {ECO:0000313|EMBL:AAO77684.1, ECO:0000313|Proteomes:UP000001414}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29148 / DSM 2079 / JCM 5827 / CCUG 10774 / NCTC 10582 /
RC   VPI-5482 / E50 {ECO:0000313|Proteomes:UP000001414};
RX   PubMed=12663928; DOI=10.1126/science.1080029;
RA   Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C.,
RA   Hooper L.V., Gordon J.I.;
RT   "A genomic view of the human-Bacteroides thetaiotaomicron symbiosis.";
RL   Science 299:2074-2076(2003).
RN   [2] {ECO:0000313|EMBL:AAO77684.1, ECO:0000313|Proteomes:UP000001414}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29148 / DSM 2079 / JCM 5827 / CCUG 10774 / NCTC 10582 /
RC   VPI-5482 / E50 {ECO:0000313|Proteomes:UP000001414};
RX   PubMed=19321416; DOI=10.1073/pnas.0901529106;
RA   Mahowald M.A., Rey F.E., Seedorf H., Turnbaugh P.J., Fulton R.S.,
RA   Wollam A., Shah N., Wang C., Magrini V., Wilson R.K., Cantarel B.L.,
RA   Coutinho P.M., Henrissat B., Crock L.W., Russell A., Verberkmoes N.C.,
RA   Hettich R.L., Gordon J.I.;
RT   "Characterizing a model human gut microbiota composed of members of its two
RT   dominant bacterial phyla.";
RL   Proc. Natl. Acad. Sci. U.S.A. 106:5859-5864(2009).
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DR   EMBL; AE015928; AAO77684.1; -; Genomic_DNA.
DR   RefSeq; NP_811490.1; NC_004663.1.
DR   RefSeq; WP_011108364.1; NC_004663.1.
DR   STRING; 226186.BT_2577; -.
DR   PaxDb; 226186-BT_2577; -.
DR   EnsemblBacteria; AAO77684; AAO77684; BT_2577.
DR   GeneID; 60923750; -.
DR   KEGG; bth:BT_2577; -.
DR   PATRIC; fig|226186.12.peg.2630; -.
DR   eggNOG; COG5635; Bacteria.
DR   HOGENOM; CLU_257787_0_0_10; -.
DR   InParanoid; Q8A4M2; -.
DR   OrthoDB; 9757917at2; -.
DR   Proteomes; UP000001414; Chromosome.
DR   Gene3D; 2.40.10.10; Trypsin-like serine proteases; 2.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR009003; Peptidase_S1_PA.
DR   InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR   Pfam; PF13365; Trypsin_2; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000001414}.
SQ   SEQUENCE   1407 AA;  164477 MW;  8C616FA79215581C CRC64;
     MSYLNGKTVE TLVVPVHCES EQGTAFFISD TQLLTARHVV KAHFQSVAAP AAIYINVAGQ
     SLLCMGEELS IPGNAIDLAL LTVVPEADYH ATEYMTLLCD VYVKNLPLRV YGYPQEMAMG
     CNLVDLEVRN RLEIEGGVWN NRTLIRDDKL TLHNFDGLSG SPVVSMSGRV TGIIVLQINE
     TLSYLSVSKA KEHLDNKGIR YDIDWVTDDI TTMGIGRSYQ LCKDAVATVH GRYMPKLHQE
     NRDLEKTLDN ISDKQQLEES AKKAATLSEC ISKLPDHMKE MIQNKLKIWL DLDIDMLMAN
     GCSILKRCYD YIESEHPFRS GGYSDKVRKL NEIVYELKEE DFERLRFTET KNLCLIGKAG
     SGKTHCLCEY ALKNQTKTNI YLFFGTDFQA YQSAISYIRD MVCQEMSFAD FNQELKNRGR
     YAVIVIDAIN EGLGCSYWNN HLGALRVELE NYDHIRLIIS VRIPFDKEMN DLLESKKWHI
     QIIEGFVNKA KAIDDYFEEY GIDQHYRNHR IEAFKNPLFL KIFCETFHSL TENERRHVNK
     QMLYKRYVTK KNEKVTDLVD EDPELNIADK YLSKLANYSV FYNHFNPITR RKARQYGQRM
     APYRLWEKDL LHACLTANLL LDDRSHTGEP AVMFEYENLG DYYKAGELLQ SKMDVKGLLR
     WIDDERKYLE RNTTVPSEKF RTAVKALFDC WYHKKLEVYD ERLIQKGGPL YELYYDFLME
     LDITDQQLIS ILQRLDNDKV NPLRLVQKFG EVTLDEALQI HEKLKTYSTV GRRDLMWTRY
     VNQMYEMYGD KYIGEVPLEQ DYTLEVSDGE REYLICITWM LSSSHPKFRA IIIRKLRKIL
     QIHQTLILWL IRLFENVNDP YVLGGLYCAV CGVVLPSRDK ELTSAIACCI FHLYYEHEET
     VPQDLIVRQW TLKIIERAYY LDEACDYWKC IRTPFKPQPI DESAIPEYHH ITQGYFGLQQ
     GSIKMYNSLF SLEDFNRYII GTNNRHFSND YFLLTEGGKY QGILLHNIMA EMAYYIMKVF
     DWNDKLGYLD NGKYSPDRSH NNQERIGKKF QWLAWHRVNA RMMDACRTSK EQYYYSDEAE
     EKDLISNPYP WNTAEISRFD PTLDVEQKYE PEAGLIGIEI QPIKGKEEEY WINKNEYLPD
     FRCMAKLQDG PEYVMLMGYD TSKEDEKETF LFSNAGFVKQ EDAEKFADWA KNQNFYGRWM
     PERRGMIEFL WNDYPWADVY KSSIEHEVWS RSHDCPCDMQ LSYEAQLQED WEGIGRENEF
     LSTVYMPCAE MMDQMGLYCS EIRGVIKATD GSVAALNTGH GNCINGLFVR RDILNDYLKR
     NGYVMFYYVL GEKVLRIGEM NFIMKDLSAA YQFQPENEAL VIQPMRIIER VALKKKNDEE
     RLTSHEMADA DFGELLKVIS EDKNEDE
//