ID Q8AW81_DANRE Unreviewed; 1305 AA.
AC Q8AW81;
DT 01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2003, sequence version 1.
DT 27-MAR-2024, entry version 150.
DE RecName: Full=Receptor protein-tyrosine kinase {ECO:0000256|ARBA:ARBA00011902, ECO:0000256|PIRNR:PIRNR000619};
DE EC=2.7.10.1 {ECO:0000256|ARBA:ARBA00011902, ECO:0000256|PIRNR:PIRNR000619};
GN Name=erbb3a {ECO:0000313|RefSeq:NP_001005320.1,
GN ECO:0000313|ZFIN:ZDB-GENE-030916-3};
GN Synonyms=ERBB {ECO:0000313|RefSeq:NP_001005320.1}, erbb3
GN {ECO:0000313|RefSeq:NP_001005320.1}, im:7148890
GN {ECO:0000313|RefSeq:NP_001005320.1}, si:dz150i12.1
GN {ECO:0000313|RefSeq:NP_001005320.1};
GN ORFNames=dZ150I12.1-001 {ECO:0000313|EMBL:CAD58760.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|EMBL:CAD58760.1};
RN [1] {ECO:0000313|RefSeq:NP_001005320.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=15797019; DOI=10.1016/j.cub.2005.02.030;
RA Lyons D.A., Pogoda H.M., Voas M.G., Woods I.G., Diamond B., Nix R.,
RA Arana N., Jacobs J., Talbot W.S.;
RT "erbb3 and erbb2 are essential for schwann cell migration and myelination
RT in zebrafish.";
RL Curr. Biol. 15:513-524(2005).
RN [2] {ECO:0000313|RefSeq:NP_001005320.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=15886089;
RA Lai C.;
RT "Peripheral glia: Schwann cells in motion.";
RL Curr. Biol. 15:R332-R334(2005).
RN [3] {ECO:0000313|RefSeq:NP_001005320.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=16109975;
RA Woods I.G., Wilson C., Friedlander B., Chang P., Reyes D.K., Nix R.,
RA Kelly P.D., Chu F., Postlethwait J.H., Talbot W.S.;
RT "The zebrafish gene map defines ancestral vertebrate chromosomes.";
RL Genome Res. 15:1307-1314(2005).
RN [4] {ECO:0000313|RefSeq:NP_001005320.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=18508863;
RA Budi E.H., Patterson L.B., Parichy D.M.;
RT "Embryonic requirements for ErbB signaling in neural crest development and
RT adult pigment pattern formation.";
RL Development 135:2603-2614(2008).
RN [5] {ECO:0000313|RefSeq:NP_001005320.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=19133254;
RA Rojas-Munoz A., Rajadhyksha S., Gilmour D., van Bebber F., Antos C.,
RA Rodriguez Esteban C., Nusslein-Volhard C., Izpisua Belmonte J.C.;
RT "ErbB2 and ErbB3 regulate amputation-induced proliferation and migration
RT during vertebrate regeneration.";
RL Dev. Biol. 327:177-190(2009).
RN [6] {ECO:0000313|EMBL:CAD58760.1}
RP NUCLEOTIDE SEQUENCE.
RA Sehra H.;
RL Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases.
RN [7] {ECO:0000313|RefSeq:NP_001005320.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23364329;
RA Dooley C.M., Mongera A., Walderich B., Nusslein-Volhard C.;
RT "On the embryonic origin of adult melanophores: the role of ErbB and Kit
RT signalling in establishing melanophore stem cells in zebrafish.";
RL Development 140:1003-1013(2013).
RN [8] {ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [9] {ECO:0000313|RefSeq:NP_001005320.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23234507;
RA Challa A.K., Chatti K.;
RT "Conservation and early expression of zebrafish tyrosine kinases support
RT the utility of zebrafish as a model for tyrosine kinase biology.";
RL Zebrafish 10:264-274(2013).
RN [10] {ECO:0000313|RefSeq:NP_001005320.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26469318;
RA Elkon R., Milon B., Morrison L., Shah M., Vijayakumar S., Racherla M.,
RA Leitch C.C., Silipino L., Hadi S., Weiss-Gayet M., Barras E., Schmid C.D.,
RA Ait-Lounis A., Barnes A., Song Y., Eisenman D.J., Eliyahu E.,
RA Frolenkov G.I., Strome S.E., Durand B., Zaghloul N.A., Jones S.M.,
RA Reith W., Hertzano R.;
RT "RFX transcription factors are essential for hearing in mice.";
RL Nat. Commun. 6:8549-8549(2015).
RN [11] {ECO:0000313|RefSeq:NP_001005320.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26110643;
RA Westcot S.E., Hatzold J., Urban M.D., Richetti S.K., Skuster K.J.,
RA Harm R.M., Lopez Cervera R., Umemoto N., McNulty M.S., Clark K.J.,
RA Hammerschmidt M., Ekker S.C.;
RT "Protein-Trap Insertional Mutagenesis Uncovers New Genes Involved in
RT Zebrafish Skin Development, Including a Neuregulin 2a-Based ErbB Signaling
RT Pathway Required during Median Fin Fold Morphogenesis.";
RL PLoS ONE 10:e0130688-e0130688(2015).
RN [12] {ECO:0000313|RefSeq:NP_001005320.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=27846271;
RA Samsa L.A., Ito C.E., Brown D.R., Qian L., Liu J.;
RT "IgG-Containing Isoforms of Neuregulin-1 Are Dispensable for Cardiac
RT Trabeculation in Zebrafish.";
RL PLoS ONE 11:e0166734-e0166734(2016).
RN [13] {ECO:0000313|RefSeq:NP_001005320.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001171};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
CC kinase family. EGF receptor subfamily. {ECO:0000256|PIRNR:PIRNR000619}.
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DR EMBL; AL591365; CAD58760.1; -; Genomic_DNA.
DR RefSeq; NP_001005320.1; NM_001005320.1.
DR GeneID; 386635; -.
DR KEGG; dre:386635; -.
DR AGR; ZFIN:ZDB-GENE-030916-3; -.
DR CTD; 386635; -.
DR ZFIN; ZDB-GENE-030916-3; erbb3a.
DR OrthoDB; 1614410at2759; -.
DR PhylomeDB; Q8AW81; -.
DR SignaLink; Q8AW81; -.
DR Proteomes; UP000000437; Chromosome 6.
DR GO; GO:0009925; C:basal plasma membrane; IBA:GO_Central.
DR GO; GO:0043235; C:receptor complex; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0038132; F:neuregulin binding; IBA:GO_Central.
DR GO; GO:0038131; F:neuregulin receptor activity; IBA:GO_Central.
DR GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IBA:GO_Central.
DR GO; GO:0022008; P:neurogenesis; IBA:GO_Central.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central.
DR GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IBA:GO_Central.
DR CDD; cd00064; FU; 1.
DR CDD; cd05111; PTK_HER3; 1.
DR CDD; cd12095; TM_ErbB3; 1.
DR Gene3D; 6.10.250.2930; -; 1.
DR Gene3D; 3.80.20.20; Receptor L-domain; 2.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR044912; Egfr_JX_dom.
DR InterPro; IPR006211; Furin-like_Cys-rich_dom.
DR InterPro; IPR006212; Furin_repeat.
DR InterPro; IPR032778; GF_recep_IV.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR000494; Rcpt_L-dom.
DR InterPro; IPR036941; Rcpt_L-dom_sf.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR016245; Tyr_kinase_EGF/ERB/XmrK_rcpt.
DR PANTHER; PTHR24416:SF88; RECEPTOR TYROSINE-PROTEIN KINASE ERBB-3; 1.
DR PANTHER; PTHR24416; TYROSINE-PROTEIN KINASE RECEPTOR; 1.
DR Pfam; PF00757; Furin-like; 1.
DR Pfam; PF14843; GF_recep_IV; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR Pfam; PF01030; Recep_L_domain; 2.
DR PIRSF; PIRSF000619; TyrPK_EGF-R; 2.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00261; FU; 3.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR000619};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|PIRNR:PIRNR000619};
KW Membrane {ECO:0000256|PIRNR:PIRNR000619, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRNR:PIRNR000619};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|PIRNR:PIRNR000619};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Signal {ECO:0000256|SAM:SignalP, ECO:0000313|RefSeq:NP_001005320.1};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR000619};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Tyrosine-protein kinase {ECO:0000256|PIRNR:PIRNR000619}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..1305
FT /note="Receptor protein-tyrosine kinase"
FT /evidence="ECO:0000256|SAM:SignalP,
FT ECO:0000313|RefSeq:NP_001005320.1"
FT /id="PRO_5035034087"
FT TRANSMEM 593..615
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 659..926
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 991..1014
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1057..1096
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1107..1126
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1157..1290
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1064..1085
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1157..1208
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 665..673
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000619-2"
FT BINDING 692
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000619-2,
FT ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 1305 AA; 145710 MW; D026607B19759224 CRC64;
MYKCMCICVN NFTLSLSLSA VGVCTGTQNL LSVTGSSEVQ YKLMKEMYTG CQIVIGNLEI
TQMEHNRDFS FLQSIREVTG YILIAINQFR RLPLEQLRVI RGTSLYEDKF ALAVLVNYQK
DGVYGLRELG LTHLTEILEG GVQIIQNKFL SYAPQINWQD IVKNSGAEVI IQDNGPEVPC
HESCGGPCWG PGNDTCQILT KTVCALQCNV RCFGRSPSEC CHNECAGGCT GPLDTDCFAC
RNFNNSGSCV SQCPRADIYN KVTFKMEPNP NAKYQFGSMC VSHCPPNFVV DGSSCVSSCP
ADKMEVDKTG VKRCEKCEGL CPKACVGTGT GTASRQTVDS QNIDSFINCT KIQGSLHFLV
TGIKGDSYNN ISALDPRKLK IFNTVREITD ILSIQSWPEE LEDLSVFSNL ATIQGRTLYR
GYSLLVMKIP TLKSLGLRSL KRISDGGIYI TGNTQLCYHH TVNWTRLFGS GPRALRRQKS
LDIKENRPQE QCRLLGSGTR SVFVLQELQK RRNMCTRLQL HVRGSDECKA CAHLQDGPYC
VSSCPEGVQG ENGLIIYKFP NRQNKCQPCH ANCTLGSTHY GVNIVRYRLP VTAIVLSVIF
CVLLAFSVFV LSVLYRRSLS IRRKRAMRRY LQSGESFEPL EPGEKGVKVH ARILRTSELK
KIKLLGSGVF GTVHKGIWIP EGDTVKIPVA IKTIQDRTGR QTFQEITDHM LAMGSLDHAY
IVRILGICPG ASLQLVTQLS PQGSLLEHIR QRRDNLNPQR LLNWCVQIAK GMYYLEEQRM
VHRNLAARNI LLKSDLIVQI ADYGIADLLY PDDKKYFFNE IKTPIKWMAL ESILFRRYTH
QSDVWSYGVT VWEMMSYGAE PYSAMRPQEV PDLLEKGERL SQPQICTIDV YMVMVKCWMI
DENVRPTFKE LANEFTRMAR DPHRYLVIKE EDRAPDSASD ETHQNGTEID ILGVALEDQD
DEVLEDAIDA PRYITPSRSF SRLRIDSHRS SLTPSTTAGY LPMTPGLESS VQTGWASRSR
LDSACTVSES SEGRGALELE MNDDFSSVGS LRRVRHREDS AYMSQRDSLS GPPETTSTGT
QGEEDQNEYV LPGFGESPEK ETLLFTSSRS TLSQKRLSRG HSGDFLEANR GAGEEYEYMN
NQTLSLSHIP GQLKEYNQRA PRNRSASFNP GGMYSNHKPS RPSKRSSIEG SESSGGLSQS
STDQRSHSDG DFLSSEAEYT DGDLEGGGGE AYEYEDMDSL AAGGASGAEY QNLDGEDEER
DEDWSGGPRS PGPYVQVHAG TNHNAFDNPD YWHSRSFHKT KAVHT
//
