ID Q8BEK5_COWPX Unreviewed; 313 AA.
AC Q8BEK5; Q2TFU0; Q2TFU1; Q2TFU2; Q2TFU3; Q2TFU4;
DT 01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2003, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE RecName: Full=Hemagglutinin {ECO:0000256|ARBA:ARBA00030815};
GN Name=HA {ECO:0000313|EMBL:AAN47017.1};
OS Cowpox virus (CPV).
OC Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus.
OX NCBI_TaxID=10243 {ECO:0000313|EMBL:AAN47017.1};
OH NCBI_TaxID=10129; Apodemus sylvaticus (European woodmouse).
OH NCBI_TaxID=9913; Bos taurus (Bovine).
OH NCBI_TaxID=9685; Felis catus (Cat) (Felis silvestris catus).
OH NCBI_TaxID=9606; Homo sapiens (Human).
OH NCBI_TaxID=9785; Loxodonta africana (African elephant).
OH NCBI_TaxID=29092; Microtus agrestis (Short-tailed field vole).
OH NCBI_TaxID=10090; Mus musculus (Mouse).
OH NCBI_TaxID=447135; Myodes glareolus (Bank vole) (Clethrionomys glareolus).
RN [1] {ECO:0000313|EMBL:AAN47017.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Cpx-58 {ECO:0000313|EMBL:AAN47017.1};
RA Esposito J.J., Ropp S.L., Jin Q., Cai B., Knight J.C., Yu L.,
RA Taubenberger J.K., Tsai M.M., Nowotny N., Meyer H., Cavallaro K.F.;
RT "Phylogenetic Analysis of Orthopoxviruses.";
RL Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AAX89865.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CPX P2 Vero {ECO:0000313|EMBL:AAX89868.2}, EP 3297
RC {ECO:0000313|EMBL:AAX89867.2}, EP-1 {ECO:0000313|EMBL:AAX89866.2},
RC EP-3299 {ECO:0000313|EMBL:AAX89869.2}, and Ratte Moskau
RC {ECO:0000313|EMBL:AAX89865.2};
RA Ropp S.L., Meyer H., Frace A.M., Sammons S.A., Govil D., Obsborne J.D.,
RA Bing C., Li Y., Knight J.C., Loparev V.N., Taubenberger J.K., Tsai M.M.,
RA Kolodziejek J., Nowotny N., Esposito J.J.;
RT "Sequence diversity of the orthopoxvirus hemagglutinin gene - a tool for
RT molecular diagnostics and phylogeny.";
RL Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Host membrane {ECO:0000256|ARBA:ARBA00004313};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004313}.
CC Virion membrane {ECO:0000256|ARBA:ARBA00004563}; Single-pass type I
CC membrane protein {ECO:0000256|ARBA:ARBA00004563}.
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DR EMBL; AF375083; AAN47017.1; -; Genomic_DNA.
DR EMBL; AY902263; AAX89865.2; -; Genomic_DNA.
DR EMBL; AY902264; AAX89866.2; -; Genomic_DNA.
DR EMBL; AY902265; AAX89867.2; -; Genomic_DNA.
DR EMBL; AY902266; AAX89868.2; -; Genomic_DNA.
DR EMBL; AY902267; AAX89869.2; -; Genomic_DNA.
DR SMR; Q8BEK5; -.
DR GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013106; Ig_V-set.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 4: Predicted;
KW Hemagglutinin {ECO:0000256|ARBA:ARBA00022546};
KW Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW Late protein {ECO:0000256|ARBA:ARBA00022921};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Viral envelope protein {ECO:0000256|ARBA:ARBA00022879};
KW Virion {ECO:0000256|ARBA:ARBA00022879}.
FT TRANSMEM 278..300
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 5..105
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
SQ SEQUENCE 313 AA; 34529 MW; CCCB6A78A6960CDC CRC64;
MTRLPILLLL ISLVYATPYP QTQISKKIGD DATLSCSRNN TSDYVVMSAW YKEPNSIILL
AAKSDVLYFD KYTKDKISYD SPYDDLVTTI TIKSLTAGDA GTYVCAFFMT STTNDTDKVD
YEEYSTELIV NTDSESTIDI ILSGSTHSPE TSSEKPEDID NSNCSSAFEI ATPEPITDNE
EDHTVTYTSE NINTVSTTSG ESTTDETPEP ITDKEEDHAV SYTTVSTSSG IVTTKSTIND
ADLYDTYNDN ESSTVSPTTV ENITKSIGKY STKDYVEVFG IAALIILSAV AVFCITYYIC
NKRSRKYKTE NKV
//
