ID Q8CVE4_LEPIN Unreviewed; 2588 AA.
AC Q8CVE4;
DT 01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2003, sequence version 1.
DT 27-MAR-2024, entry version 107.
DE SubName: Full=TolB-related protein {ECO:0000313|EMBL:AAN50265.1};
GN OrderedLocusNames=LA_3067 {ECO:0000313|EMBL:AAN50265.1};
OS Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain
OS 56601).
OC Bacteria; Spirochaetota; Spirochaetia; Leptospirales; Leptospiraceae;
OC Leptospira.
OX NCBI_TaxID=189518 {ECO:0000313|EMBL:AAN50265.1, ECO:0000313|Proteomes:UP000001408};
RN [1] {ECO:0000313|EMBL:AAN50265.1, ECO:0000313|Proteomes:UP000001408}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=56601 {ECO:0000313|EMBL:AAN50265.1,
RC ECO:0000313|Proteomes:UP000001408};
RX PubMed=12712204; DOI=10.1038/nature01597;
RA Ren S.X., Fu G., Jiang X.G., Zeng R., Miao Y.G., Xu H., Zhang Y.X.,
RA Xiong H., Lu G., Lu L.F., Jiang H.Q., Jia J., Tu Y.F., Jiang J.X., Gu W.Y.,
RA Zhang Y.Q., Cai Z., Sheng H.H., Yin H.F., Zhang Y., Zhu G.F., Wan M.,
RA Huang H.L., Qian Z., Wang S.Y., Ma W., Yao Z.J., Shen Y., Qiang B.Q.,
RA Xia Q.C., Guo X.K., Danchin A., Saint Girons I., Somerville R.L., Wen Y.M.,
RA Shi M.H., Chen Z., Xu J.G., Zhao G.P.;
RT "Unique physiological and pathogenic features of Leptospira interrogans
RT revealed by whole-genome sequencing.";
RL Nature 422:888-893(2003).
CC -!- SIMILARITY: Belongs to the TolB family.
CC {ECO:0000256|ARBA:ARBA00009820}.
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DR EMBL; AE010300; AAN50265.1; -; Genomic_DNA.
DR RefSeq; NP_713247.1; NC_004342.2.
DR RefSeq; WP_000251296.1; NC_004342.2.
DR STRING; 189518.LA_3067; -.
DR PaxDb; 189518-LA_3067; -.
DR EnsemblBacteria; AAN50265; AAN50265; LA_3067.
DR KEGG; lil:LA_3067; -.
DR PATRIC; fig|189518.3.peg.3044; -.
DR HOGENOM; CLU_227639_0_0_12; -.
DR InParanoid; Q8CVE4; -.
DR OrthoDB; 262125at2; -.
DR Proteomes; UP000001408; Chromosome I.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 3.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 2.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR011659; PD40.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR36842; PROTEIN TOLB HOMOLOG; 1.
DR PANTHER; PTHR36842:SF1; TOL-PAL SYSTEM PROTEIN TOLB; 1.
DR Pfam; PF07676; PD40; 3.
DR SMART; SM00028; TPR; 8.
DR SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
DR SUPFAM; SSF48452; TPR-like; 3.
DR PROSITE; PS50005; TPR; 2.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000001408};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339}.
FT REPEAT 1018..1051
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 1186..1219
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT COILED 1514..1541
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 2588 AA; 299367 MW; 55C8811F374CD4EC CRC64;
MVRFGICFFS FFFFYHCSIF RAASRIKPLE FNYTSIAVNY FTPENEKPFP LTVQRGNNLY
NSTTADGSYL FYTTGQKGNY DIWFRDLKSS ITVPVTTHPA PEYKPAISPD GKKLVFVSEQ
YDSSGDLILL KMNPGLWADK ILQGKRFINS DFIILTNSNF SDTGKKDSYV DTDPFFAPDG
RHLVFSTDRL TPGIQNLVVL DTEGKEPMKL LTQKGGASPF WSKDGKSIVY ISYQDGVFGD
VYLLDLSSGK NERLTKDSYL NFSPSLSEDK RYLYYTSIQN DTNRNGRLDE RDNSLIVRKD
LKTGVVRRLT SGNDSLFDSR FSAFNGGSIL FTAAYYDTLN IYFIPASGSV SKEKDIISQY
ELALKYKEKQ SFEDFLLAID AIEFYFSQDP IYPLIFSKAL LLKYEEAKNS GKTIIAENAK
KEILSSRLNP VYGLAYGLFL SNEKKLTVSI QELRKYYEQI RAISDTGKNL LASLLEEEGD
LARKSGDSQH SLKVYDEIII HYPDYYRIRD VYRKSGDLQY KNAHLNHYKI PEPFFRVAND
LSAGKEDLKL LYERIDGEVV VGKSFSEKIN ASEISIESNS LENKSPRLFQ YFLYIKSLGL
NGKGSFEESN SLLNTFLSKV AKSDPLFLKI HLLKSNNFKG LGEVQKSFDE LRIYLEEYDP
LLGVDLEEKE IERSFIYFEN KARDHDRRGN LQDAAFHYFY NTENMFLVKS RNLFLESLYK
EFAVYYQRMM VDAVFKLSGS LSEERKKALL NQLDVIDIAK VDPLAEEGLV YINQYYKEAV
PRARPVLDLA TLYGYSYYLI NRSVIRETYY NSTKSMTSSK KEEILRDFKQ AEYELRWIIF
ADPRYYEAYQ LLGWMYQYVD ILKNRKSGED QPSDEEKYIS VYEKYFPEKN FEENIELYSQ
VLELLGDNFE NKKALSDLRL NLGNNYFLLK NYPKANEQYS KVDSLSDYII SKTQFEDYRQ
KAIFLFNSAR SSIYVADYKS AIQKLKAASD IYFRNESKKT IVGKDSAEKL EQYKLKLALL
FTLTGLSYME AGEYSNAIPY YKDALSLNGE NGWIDPVNLH NGLALCYQKL GKYKLSELHL
TKADKIVDDR VGTGWIPRGV KLAFWDYFWD WVWEVALPDG VRISGEGRFP EAISPKFQPL
MTSGIRVNNL IASMEIDGAI KEINSRLAYV KSKSLGTTLA GSLIGANSLN DLGYLHFKRD
EFKNAIDVYE QAEKFETEKG FAAKARTSFK RKLYSYFGHL ENTNEDPELE LRTLGSAAER
ILSSKSDFIK GCLGDVQYQE ELIYSETKKC ILKFYNSFSD HDPTLALIYY YQGEQFFRMG
NFVAAFEFFG KSAGLLENPS LVPKEVVGLA DDPYSRKERL SYSISRANLY VRLEDSQKAI
SLLELASETA NEFYYIQEWI EALVTQAEIF RKEKNDFKAK EKIDKASTLL LSHPHLISEL
KYFIIYKLFK IQSELNFQSG KFSDGFKSLD RLHKLKLYRQ FIKIPHESED PNFTEDITKL
QNLIKKQKFY YSAIQNALEK KEKSESLLKK YVQLSKDLEK ELGVISRKNQ DLDGYLGIFI
EEPSVTSLLD VNEGYLRIES AEDKIRIYRA TSYTEEYLVN TGKLEEVLNQ ISNSGKIPFV
SKKIWFVQLG DRIDFEKIRN FLPEKFSLVF RPSHLKPVRE KDRRTTRNVA IVDGSPNFKS
SLSVKKITPN QIFSIHLDTD MLVSPFPNIN EDNSFGESLS EKNLAVRDLF HNQNEISSAL
FYEQTKPHLG KISELYEVLN ASGIRNVAIC NASDSCATAF PEKIFSGEIS GSLFLGSSVL
RKKDVFISLE NLSLLVRENE RKDNIREAYT HAFSYRSFLK KEDMLLAAEL DVLRLKWKLS
PQVTMEEIYG DLLQNTKLET VKDSILFSAL LNCYLDKNLS DCNSYSFKDI TDFQKRNLLK
NLYLLKNGTS VEPLSLKVSD KTVFSFYDPY LYYKNILKIA RANYEPELGE FAGRLALEFT
HDPDEIIAVE EILQGLYAQK YFLQGSALSK NQIRRKEELY LILSGNWKEA LRILKEKEAE
EDTGKFRERL FRNWRREITG AWFSPYSLYS EVYGNSSKLF ESLDAEERSL LYHLILYSIP
FQENEELDLL TESLVEYEWN TGAKSRALRM VLGYSQALFS RGELSKSKDW MDKIDSRYKT
ESKSIFRDKN ILNNKLLFHL GKISSVAERD EKTEWLLLYE KAASKPPNEF VEFLNSTIRS
KRGNRFSSKE RTELLDWIVY LQKLCFKKNN SEVFFDLVLA KDLLSLTRPV VLNSIPDYKD
IPTFVAVADK LKEKLPADQE FLAVTDLGLE TFYIRFLKGK SKGDLAFKDN RKLRASLFQY
LEEAAKGGYE VLLREELENE YRRNVKLAKN KLTYLYLSSY HFRIPLVPRT EDKFYLVNDP
QSLVSNPIVS TKEEFSPEYR IQFLENSKLP ESWKKSLKEL EVFEAGSGKL GSDSKSRLYI
LQDPLEIVDQ VHLSLGGKAL ADSYGSPKKG NWIFTSSFLD DEYYDIINYR DSFYWISQNF
QSPGVIFIGE QTDTAHVDFL KRFTKRSLSK VPLYIRFQET LDAIKEAYPL DRIWNGYRLY
TNSIILEE
//
