ID Q8DVY1_STRMU Unreviewed; 166 AA.
AC Q8DVY1;
DT 01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2003, sequence version 1.
DT 27-MAR-2024, entry version 105.
DE SubName: Full=Carbonic anhydrase {ECO:0000313|EMBL:AAN58087.1};
GN OrderedLocusNames=SMU_328 {ECO:0000313|EMBL:AAN58087.1};
OS Streptococcus mutans serotype c (strain ATCC 700610 / UA159).
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=210007 {ECO:0000313|EMBL:AAN58087.1, ECO:0000313|Proteomes:UP000002512};
RN [1] {ECO:0000313|EMBL:AAN58087.1, ECO:0000313|Proteomes:UP000002512}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700610 / UA159 {ECO:0000313|Proteomes:UP000002512};
RX PubMed=12397186; DOI=10.1073/pnas.172501299;
RA Ajdic D., McShan W.M., McLaughlin R.E., Savic G., Chang J., Carson M.B.,
RA Primeaux C., Tian R., Kenton S., Jia H., Lin S., Qian Y., Li S., Zhu H.,
RA Najar F., Lai H., White J., Roe B.A., Ferretti J.J.;
RT "Genome sequence of Streptococcus mutans UA159, a cariogenic dental
RT pathogen.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:14434-14439(2002).
RN [2] {ECO:0007829|PDB:3LAS}
RP X-RAY CRYSTALLOGRAPHY (1.40 ANGSTROMS) IN COMPLEX WITH ZINC.
RA Ma L.-L., Wang K.-T., Liu X., Su X.-D.;
RT "Crystal structure of carbonic anhydrase from streptococcus mutans to 1.4
RT angstrom resolution.";
RL Submitted (JAN-2010) to the PDB data bank.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SIMILARITY: Belongs to the beta-class carbonic anhydrase family.
CC {ECO:0000256|ARBA:ARBA00006217}.
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DR EMBL; AE014133; AAN58087.1; -; Genomic_DNA.
DR RefSeq; NP_720781.1; NC_004350.2.
DR PDB; 3LAS; X-ray; 1.40 A; A/B=1-166.
DR PDBsum; 3LAS; -.
DR AlphaFoldDB; Q8DVY1; -.
DR SMR; Q8DVY1; -.
DR STRING; 210007.SMU_328; -.
DR KEGG; smu:SMU_328; -.
DR PATRIC; fig|210007.7.peg.283; -.
DR eggNOG; COG0288; Bacteria.
DR HOGENOM; CLU_084253_1_1_9; -.
DR OrthoDB; 9792260at2; -.
DR PhylomeDB; Q8DVY1; -.
DR EvolutionaryTrace; Q8DVY1; -.
DR Proteomes; UP000002512; Chromosome.
DR GO; GO:0004089; F:carbonate dehydratase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd03379; beta_CA_cladeD; 1.
DR Gene3D; 3.40.1050.10; Carbonic anhydrase; 1.
DR InterPro; IPR001765; Carbonic_anhydrase.
DR InterPro; IPR036874; Carbonic_anhydrase_sf.
DR PANTHER; PTHR43175:SF3; CARBON DISULFIDE HYDROLASE; 1.
DR PANTHER; PTHR43175; CARBONIC ANHYDRASE; 1.
DR Pfam; PF00484; Pro_CA; 1.
DR SMART; SM00947; Pro_CA; 1.
DR SUPFAM; SSF53056; beta-carbonic anhydrase, cab; 1.
PE 1: Evidence at protein level;
KW 3D-structure {ECO:0007829|PDB:3LAS};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0007829|PDB:3LAS};
KW Reference proteome {ECO:0000313|Proteomes:UP000002512};
KW Zinc {ECO:0007829|PDB:3LAS}.
FT BINDING 38
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0007829|PDB:3LAS"
FT BINDING 91
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0007829|PDB:3LAS"
FT BINDING 94
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0007829|PDB:3LAS"
FT BINDING 126
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0007829|PDB:3LAS"
SQ SEQUENCE 166 AA; 18227 MW; 94B381FDB0B4F685 CRC64;
MVMSYFDNFI KANQAYVDLH GTAHLPLKPK TRVAIVTCMD SRLHVAPALG LALGDAHILR
NAGGRVTDDV IRSLVISEQQ LGTSEIVVLH HTDCGAQTFT NAEFTEQLKR DLAVDAGDQD
FLPFTDIEES VREDIALLKN SPLIPEDIII SGAIYDVDTG RVREVN
//
