ID   Q8E4C3_STRA3            Unreviewed;       901 AA.
AC   Q8E4C3;
DT   01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2003, sequence version 1.
DT   27-MAR-2024, entry version 103.
DE   RecName: Full=VWFA domain-containing protein {ECO:0000259|PROSITE:PS50234};
GN   OrderedLocusNames=gbs1478 {ECO:0000313|EMBL:CAD47137.1};
OS   Streptococcus agalactiae serotype III (strain NEM316).
OC   Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=211110 {ECO:0000313|EMBL:CAD47137.1};
RN   [1] {ECO:0000313|EMBL:CAD47137.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NEM316 {ECO:0000313|EMBL:CAD47137.1};
RX   PubMed=12354221; DOI=10.1046/j.1365-2958.2002.03126.x;
RA   Glaser P., Rusniok C., Buchrieser C., Chevalier F., Frangeul L., Msadek T.,
RA   Zouine M., Couve E., Lalioui L., Poyart C., Trieu-Cuot P., Kunst F.;
RT   "Genome sequence of Streptococcus agalactiae, a pathogen causing invasive
RT   neonatal disease.";
RL   Mol. Microbiol. 45:1499-1513(2002).
CC   -!- SIMILARITY: Belongs to the serine-aspartate repeat-containing protein
CC       (SDr) family. {ECO:0000256|ARBA:ARBA00007257}.
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DR   EMBL; AL766851; CAD47137.1; -; Genomic_DNA.
DR   RefSeq; WP_001233990.1; NC_004368.1.
DR   AlphaFoldDB; Q8E4C3; -.
DR   KEGG; san:gbs1478; -.
DR   eggNOG; COG2304; Bacteria.
DR   eggNOG; COG4932; Bacteria.
DR   HOGENOM; CLU_323622_0_0_9; -.
DR   Proteomes; UP000000823; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   CDD; cd00198; vWFA; 1.
DR   Gene3D; 2.60.40.2110; -; 2.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR   InterPro; IPR049319; GBS104-like_Ig.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR041033; Prealbumin-like.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   NCBIfam; TIGR01167; LPXTG_anchor; 1.
DR   PANTHER; PTHR36108:SF13; COLOSSIN-B; 1.
DR   PANTHER; PTHR36108; COLOSSIN-B-RELATED; 1.
DR   Pfam; PF21426; GBS104-like_Ig; 1.
DR   Pfam; PF17802; SpaA; 2.
DR   Pfam; PF13519; VWA_2; 1.
DR   SMART; SM00327; VWA; 1.
DR   SUPFAM; SSF49478; Cna protein B-type domain; 1.
DR   SUPFAM; SSF53300; vWA-like; 1.
DR   PROSITE; PS50234; VWFA; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius}; Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           20..901
FT                   /note="VWFA domain-containing protein"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5039284274"
FT   TRANSMEM        867..887
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          230..467
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
FT   REGION          119..146
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          163..186
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   901 AA;  101216 MW;  B66C956163EC7DBD CRC64;
     MRKYQKFSKI LTLSLFCLSQ IPLNTNVLGE STVPENGAKG KLVVKKTDDQ NKPLSKATFV
     LKTTAHPESK IEKVTAELTG EATFDNLIPG DYTLSEETAP EGYKKTNQTW QVKVESNGKT
     TIQNSGDKNS TIGQNHEELD KQYPPTGIYE DTKESYKLEH VKGSVPNGKS EAKAVNPYSS
     EGEHIREIPE GTLSKRISEV GDLAHNKYKI ELTVSGKTIV KPVDKQKPLD VVFVLDNSNS
     MNNDGPNFQR HNKAKKAAEA LGTAVKDILG ANSDNRVALV TYGSDIFDGR SVDVVKGFKE
     DDKYYGLQTK FTIQTENYSH KQLTNNAEEI IKRIPTEAPR AKWGSTTNGL TPEQQKQYYL
     SKVGETFTMK AFMEADDILS QVDRNSQKII VHITDGVPTR SYAINNFKLG ASYESQFEQM
     KKNGYLNKSN FLLTDKPEDI KGNGESYFLF PLDSYQTQII SGNLQKLHYL DLNLNYPKGT
     IYRNGPVREH GTPTKLYINS LKQKNYDIFN FGIDISAFRQ VYNEDYKKNQ DGTFQKLKEE
     AFELSDGEIT ELMKSFSSKP EYYTPIVTSS DASNNEILSK IQQQFEKVLT KENSIVNGTI
     EDPMGDKINL QLGNGQTLQP SDYTLQGNDG SIMKDSIATG GPNNDGGILK GVKLEYIKNK
     LYVRGLNLGE GQKVTLTYDV KLDDSFISNK FYDTNGRTTL NPKSEDPNTL RDFPIPKIRD
     VREYPTITIK NEKKLGEIEF TKVDKDNNKL LLKGATFELQ EFNEDYKLYL PIKNNNSKVV
     TGENGKISYK DLKDGKYQLI EAVSPKDYQK ITNKPILTFE VVKGSIQNII AVNKQISEYH
     EEGDKHLITN THIPPKGIIP MTGGKGILSF ILIGGSMMSI AGGIYIWKRY KKSSDISREK
     D
//