ID Q8ENM2_OCEIH Unreviewed; 494 AA.
AC Q8ENM2;
DT 01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2003, sequence version 1.
DT 27-MAR-2024, entry version 108.
DE RecName: Full=4,4'-diaponeurosporene oxygenase {ECO:0000256|ARBA:ARBA00039159};
DE AltName: Full=4,4'-diaponeurosporene oxidase {ECO:0000256|ARBA:ARBA00041900};
DE AltName: Full=Carotenoid oxidase {ECO:0000256|ARBA:ARBA00042619};
GN OrderedLocusNames=OB2459 {ECO:0000313|EMBL:BAC14415.1};
OS Oceanobacillus iheyensis (strain DSM 14371 / CIP 107618 / JCM 11309 / KCTC
OS 3954 / HTE831).
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Oceanobacillus.
OX NCBI_TaxID=221109 {ECO:0000313|EMBL:BAC14415.1, ECO:0000313|Proteomes:UP000000822};
RN [1] {ECO:0000313|EMBL:BAC14415.1, ECO:0000313|Proteomes:UP000000822}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 14371 / CIP 107618 / JCM 11309 / KCTC 3954 / HTE831
RC {ECO:0000313|Proteomes:UP000000822};
RX PubMed=12235376; DOI=10.1093/nar/gkf526;
RA Takami H., Takaki Y., Uchiyama I.;
RT "Genome sequence of Oceanobacillus iheyensis isolated from the Iheya Ridge
RT and its unexpected adaptive capabilities to extreme environments.";
RL Nucleic Acids Res. 30:3927-3935(2002).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 AH2 + all-trans-4,4'-diaponeurosporene + 2 O2 = 4,4'-
CC diaponeurosporenal + 2 A + 3 H2O; Xref=Rhea:RHEA:56104,
CC ChEBI:CHEBI:13193, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379,
CC ChEBI:CHEBI:17499, ChEBI:CHEBI:62743, ChEBI:CHEBI:79065;
CC Evidence={ECO:0000256|ARBA:ARBA00035945};
CC -!- PATHWAY: Carotenoid biosynthesis; staphyloxanthin biosynthesis;
CC staphyloxanthin from farnesyl diphosphate: step 3/5.
CC {ECO:0000256|ARBA:ARBA00037901}.
CC -!- SIMILARITY: Belongs to the carotenoid/retinoid oxidoreductase family.
CC CrtP subfamily. {ECO:0000256|ARBA:ARBA00038194}.
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DR EMBL; BA000028; BAC14415.1; -; Genomic_DNA.
DR AlphaFoldDB; Q8ENM2; -.
DR STRING; 221109.gene:10734711; -.
DR KEGG; oih:OB2459; -.
DR eggNOG; COG1233; Bacteria.
DR HOGENOM; CLU_019722_2_1_9; -.
DR PhylomeDB; Q8ENM2; -.
DR Proteomes; UP000000822; Chromosome.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0016117; P:carotenoid biosynthetic process; IEA:UniProtKB-KW.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 2.
DR InterPro; IPR002937; Amino_oxidase.
DR InterPro; IPR014105; Carotenoid/retinoid_OxRdtase.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR NCBIfam; TIGR02734; crtI_fam; 1.
DR PANTHER; PTHR43734:SF7; 4,4'-DIAPONEUROSPORENE OXYGENASE; 1.
DR PANTHER; PTHR43734; PHYTOENE DESATURASE; 1.
DR Pfam; PF01593; Amino_oxidase; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 3: Inferred from homology;
KW Carotenoid biosynthesis {ECO:0000256|ARBA:ARBA00022746,
KW ECO:0000256|RuleBase:RU362075};
KW Oxidoreductase {ECO:0000256|RuleBase:RU362075,
KW ECO:0000313|EMBL:BAC14415.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000822}.
FT DOMAIN 11..489
FT /note="Amine oxidase"
FT /evidence="ECO:0000259|Pfam:PF01593"
SQ SEQUENCE 494 AA; 56213 MW; 4F325BA8A4810B56 CRC64;
MKKVIIIGGG LGGLSAAISM AQLGYSVELF EKNHHLGGKL NRLEQDGFGF DLGPSILTMP
HIFERLFANS GKRMEDYISI YQLSHEWRSF FTDGTTIDLY NNPDKMLKQN PSLTERDIKE
YKSFLQYAKQ IDDITTKGYF DKGLDTTWEI IQEHGMIQSL KKFDLTSTMY EGIEKRITNP
KLRSMLAYFI KYVGSSPYDA PAVLNMLIYM QHAYGAWYVP GGMHKIAEGL VKLANELDVQ
IHTNSEVTKL KKDSTGNVIA ATLADDSEIK GDIFISNMEV IPTYEKLLME KSSYIKKLTK
KYEPSSSGLV LHLGVKNSYP QLSHHNFFFS HNLKEQMNQV FHKHQLPDDP TIYLVNTNKT
DPNQVPGPGY ENIKILPHIP YIQDKPFSDD DYKQFREQVL IKLENMGMHG LRESIVTEDM
WTPNDIQSTY YSYKGSIYGT LSNKKINRGF KHPKQSSKYD NLFFVGGSVN PGGGMPMVVL
SGQQVSEKIH QIFS
//
