ID Q8F970_LEPIN Unreviewed; 313 AA.
AC Q8F970;
DT 01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT 15-JUN-2010, sequence version 2.
DT 27-MAR-2024, entry version 99.
DE SubName: Full=Geranylgeranyl pyrophosphate synthase {ECO:0000313|EMBL:AAN47525.2};
GN Name=ispA {ECO:0000313|EMBL:AAN47525.2};
GN OrderedLocusNames=LA_0326 {ECO:0000313|EMBL:AAN47525.2};
OS Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain
OS 56601).
OC Bacteria; Spirochaetota; Spirochaetia; Leptospirales; Leptospiraceae;
OC Leptospira.
OX NCBI_TaxID=189518 {ECO:0000313|EMBL:AAN47525.2, ECO:0000313|Proteomes:UP000001408};
RN [1] {ECO:0000313|EMBL:AAN47525.2, ECO:0000313|Proteomes:UP000001408}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=56601 {ECO:0000313|EMBL:AAN47525.2,
RC ECO:0000313|Proteomes:UP000001408};
RX PubMed=12712204; DOI=10.1038/nature01597;
RA Ren S.X., Fu G., Jiang X.G., Zeng R., Miao Y.G., Xu H., Zhang Y.X.,
RA Xiong H., Lu G., Lu L.F., Jiang H.Q., Jia J., Tu Y.F., Jiang J.X., Gu W.Y.,
RA Zhang Y.Q., Cai Z., Sheng H.H., Yin H.F., Zhang Y., Zhu G.F., Wan M.,
RA Huang H.L., Qian Z., Wang S.Y., Ma W., Yao Z.J., Shen Y., Qiang B.Q.,
RA Xia Q.C., Guo X.K., Danchin A., Saint Girons I., Somerville R.L., Wen Y.M.,
RA Shi M.H., Chen Z., Xu J.G., Zhao G.P.;
RT "Unique physiological and pathogenic features of Leptospira interrogans
RT revealed by whole-genome sequencing.";
RL Nature 422:888-893(2003).
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SIMILARITY: Belongs to the FPP/GGPP synthase family.
CC {ECO:0000256|RuleBase:RU004466}.
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DR EMBL; AE010300; AAN47525.2; -; Genomic_DNA.
DR RefSeq; NP_710507.2; NC_004342.2.
DR RefSeq; WP_002070306.1; NC_004342.2.
DR AlphaFoldDB; Q8F970; -.
DR STRING; 189518.LA_0326; -.
DR PaxDb; 189518-LA_0326; -.
DR EnsemblBacteria; AAN47525; AAN47525; LA_0326.
DR KEGG; lil:LA_0326; -.
DR PATRIC; fig|189518.3.peg.329; -.
DR HOGENOM; CLU_014015_0_1_12; -.
DR InParanoid; Q8F970; -.
DR OrthoDB; 9805316at2; -.
DR Proteomes; UP000001408; Chromosome I.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004659; F:prenyltransferase activity; IBA:GO_Central.
DR GO; GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro.
DR CDD; cd00685; Trans_IPPS_HT; 1.
DR Gene3D; 1.10.600.10; Farnesyl Diphosphate Synthase; 1.
DR InterPro; IPR008949; Isoprenoid_synthase_dom_sf.
DR InterPro; IPR000092; Polyprenyl_synt.
DR InterPro; IPR033749; Polyprenyl_synt_CS.
DR PANTHER; PTHR43281; FARNESYL DIPHOSPHATE SYNTHASE; 1.
DR PANTHER; PTHR43281:SF1; FARNESYL DIPHOSPHATE SYNTHASE; 1.
DR Pfam; PF00348; polyprenyl_synt; 1.
DR SFLD; SFLDS00005; Isoprenoid_Synthase_Type_I; 1.
DR SFLD; SFLDG01017; Polyprenyl_Transferase_Like; 1.
DR SUPFAM; SSF48576; Terpenoid synthases; 1.
DR PROSITE; PS00723; POLYPRENYL_SYNTHASE_1; 1.
DR PROSITE; PS00444; POLYPRENYL_SYNTHASE_2; 1.
PE 3: Inferred from homology;
KW Isoprene biosynthesis {ECO:0000256|ARBA:ARBA00023229};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Reference proteome {ECO:0000313|Proteomes:UP000001408};
KW Transferase {ECO:0000256|RuleBase:RU004466}.
SQ SEQUENCE 313 AA; 35353 MW; 2C36506190C15000 CRC64;
MNSSSFSKIF HSYKSTFENF LNSQTLSILS KQSAPELFEA MKYSLVAGGK RLRPVLALAA
FGGLQNETQN VLLLGASLEC IHTYSLIHDD LPSMDNDDFR RGLPTLHKKF SESTAILAGD
ALNSFAFYFI SWIRVENGDH FLHRNLLEIL HAGCGAPGMV SGQVYDLQME RENVKENDST
NQSDKIEMLQ LTHRLKTGAL IKSALLLGNR LRKDWKKRET SLSQYGEDLG LLFQITDDIL
DVEGTQESLG KTPGKDQKSG KITYPMLFGM DRCKKMVEEL QKNLIFTSSD FVSTEEEQTF
FQELPIYIGQ RKN
//
